Product Name

  • Name

    Rifaximin

  • EINECS 617-130-4
  • CAS No. 80621-81-4
  • Article Data1
  • CAS DataBase
  • Density 1.366 g/cm3
  • Solubility
  • Melting Point 200-205 °C(dec)
  • Formula C43H51N3O11
  • Boiling Point
  • Molecular Weight 785.891
  • Flash Point
  • Transport Information
  • Appearance Red-orange crystalline powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 80621-81-4 (Rifaximin)
  • Hazard Symbols
  • Synonyms L 105;L 105(ansamacrolide antibiotic);L 105SV;Rifamycin L 105;Rifamycin L 105SV;Xifaxan;refaximin;
  • PSA 198.38000
  • LogP 6.29580

Synthetic route

C43H50N3O11(1+)*Br(1-)

C43H50N3O11(1+)*Br(1-)

rifaximin
80621-81-4

rifaximin

Conditions
ConditionsYield
With ascorbic acid
2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

rifaximin
80621-81-4

rifaximin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CHCl3 / 2 h / Ambient temperature
2: ascorbic acid
View Scheme
3-bromorifamicin S
57375-25-4

3-bromorifamicin S

rifaximin
80621-81-4

rifaximin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CHCl3 / 2 h / Ambient temperature
2: ascorbic acid
View Scheme

Rifaximin Chemical Properties

Structure of Rifaximin (CAS NO.80621-81-4):

Empirical Formula: C43H51N3O11
Molecular Weight: 785.8785 
Index of Refraction: 1.634
Molar Refractivity: 205.697 cm3
Molar Volume: 575.317 cm3
Polarizability: 81.545×10-24cm3
Surface Tension: 48.156 dyne/cm
Density: 1.366 g/cm3 
Melting Point: 200-205°C(dec) 
Physical Appearance: Red-Orange Crystalline Powder
Product Categories: Active Pharmaceutical Ingredients;Antibacterial;Intermediates & Fine Chemicals;Pharmaceuticals 
Synonyms of Rifaximin (CAS NO.80621-81-4):  (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate ; 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV ; Fatroximin ; Normix ; Rifacol .

Rifaximin Uses

 Rifaximin (CAS NO.80621-81-4) is highly effective at preventing and treating traveler's diarrhea among travelers to Mexico, with few side effects and low risk of developing antibiotic resistance. In the United States, Rifaximin has orphan drug status for the treatment of hepatic encephalopathy.

Rifaximin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 7, Pg. 260, 1982.
rat LD50 oral > 2gm/kg (2000mg/kg)   Chemioterapia. Vol. 5, Pg. 263, 1986.

Rifaximin Safety Profile

RTECS: KD1576000

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