Product Name

  • Name

    Robenidine hydrochloride

  • EINECS 247-307-8
  • CAS No. 25875-50-7
  • Article Data4
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 252-254 °C
  • Formula C15H14Cl3N5
  • Boiling Point 475.8 °C at 760 mmHg
  • Molecular Weight 370.669
  • Flash Point 241.6 °C
  • Transport Information
  • Appearance off-white solid
  • Safety
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 25875-50-7 (Robenidine hydrochloride)
  • Hazard Symbols HarmfulXn
  • Synonyms Carbonimidicdihydrazide, bis[(4-chlorophenyl)methylene]-, monohydrochloride (9CI);Guanidine, 1,3-bis[(p-chlorobenzylidene)amino]-, monohydrochloride (8CI);1,3-Bis[(p-chlorobenzylidene)amino]guanidine monohydrochloride;Cycostat;Robenzidene;
  • PSA 72.63000
  • LogP 5.15890

Synthetic route

1,3-diaminoguanidine hydrochloride
36062-19-8

1,3-diaminoguanidine hydrochloride

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 1h; pH=1.5; pH-value; Temperature;98.82%
In ethanol for 16h; Reflux;
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

2-(isocyanatomethyl)furan
71189-15-6

2-(isocyanatomethyl)furan

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;84%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

C23H20Cl2N6O*ClH

C23H20Cl2N6O*ClH

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;61%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

ethyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

ethyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;42%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

isobutyl chloroformate
543-27-1

isobutyl chloroformate

isobutyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

isobutyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;39%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

ethyl isocyanate
109-90-0

ethyl isocyanate

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-ethylhydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-ethylhydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;33%
Hexyl isocyanate
2525-62-4

Hexyl isocyanate

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-hexylhydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-hexylhydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;16%

Robenidine hydrochloride Chemical Properties

IUPAC Name:1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine hydrochloride
Synonyms: 1,2-Bis[(4-chlorophenyl)methylideneamino]guanidine hydrochloride ; Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride ; Robenidine hydrochloride ; Khimcoecid ; N, N'-Bis (p-chlorobenzylideneamino) quanidine
Molecular Structure of Robenidine (CAS NO. 25875-51-8) :
Molecular Formula of Robenidine (CAS NO. 25875-51-8) : C15H13Cl2N5.HCl
Molecular Weight of Robenidine (CAS NO. 25875-51-8) : 370.67
CAS NO: 25875-51-8
EINECS: 247-308-3

Robenidine hydrochloride Uses

  Robenidine (CAS NO. 25875-51-8) is a coccidiostat

Robenidine hydrochloride Production

Preparation Products: Robenidine hydrochloride

Robenidine hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:1350 mg/kg

     VETNAL    Veterinariya. 57 (9)(1981),53.
2.    

orl-mus LD50:1212 mg/kg

     VETNAL    Veterinariya. 53 (11)(1976),69.
3.    

orl-rbt LD50:1245 mg/kg

     VETNAL    Veterinariya. 57 (9)(1981),53.
4.    

orl-ckn LD50:500 mg/kg

     VETNAL    Veterinariya. 57 (9)(1981),53.
5.    

orl-dck LD50:1017 mg/kg

     VETNAL    Veterinariya. 57 (9)(1981),53.

Robenidine hydrochloride Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl− and NOx.

Robenidine hydrochloride Specification

Robenidine with the cas number 25875-51-8, is also named 1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine by IUPAC. It is mainly used as coccidiostat. It is not used homemarket, because of the following cause:
Firstly, the Robenidine production cost is so high that consumer can use substitutes. Secondly, when it is used, it's drug-fast rate turned to be high rapidly. Besides, this chemical appeared bad smell. 

You can still convert the following datas into molecular structure :
1. SMILES:Clc2ccc(/C=N/NC(=N\N=C\c1ccc(Cl)cc1)\N)cc2
2. InChI:InChI=1/C15H13Cl2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)/b19-9+,20-10+

Robenidine toxic data can be showed in the following sheet.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 500mg/kg (500mg/kg)   Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981.
duck LD50 oral 1017mg/kg (1017mg/kg)   Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981.
mouse LD50 oral 1212mg/kg (1212mg/kg)   Veterinariya. Veterinary Science. Vol. 53(11), Pg. 69, 1976.
rabbit LD50 oral 1245mg/kg (1245mg/kg)   Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981.
rat LD50 oral 1350mg/kg (1350mg/kg)   Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981.

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