Ropinirole

The Ropinirole with the cas number 91374-21-9, is also called (1) 4-(2-(Dipropylamino)ethyl)-1,3-dihydro-2H-indol-2-one ; (2) Requip ; (3) Ropinirol ; (4) Ropinirole ; (5) Ropinirolum ; (6) SK&F 101468 ; (7) UNII-030PYR8953 ; (8) 2H-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-. Ropinirole belongs to the following Product Categories: (1)Pharmaceutical material andintermeidates; (2)Antiparkinsonian; (3)ACTIVE Pharmaceutical ingredients and so on.

Properties of Ropinirole are: (1)ACD/BCF (pH 5.5): 1 ; (2)ACD/BCF (pH 7.4): 1.59 ; (3)ACD/KOC (pH 5.5): 1.19 ; (4)ACD/KOC (pH 7.4): 13.1 ; (5)#H bond acceptors: 3 ; (6)#H bond donors: 1 ; (7)#Freely Rotating Bonds: 7 ; (8) Polar Surface Area: 23.55 Å² ; (9)Index of Refraction: 1.538 ; (10)Molar Refractivity: 78.36 cm³ ; (11)Molar Volume: 250.1 cm³ ; (12)Polarizability: 31.06 ×10^-24cm³ ; (13)Surface Tension: 40.4 dyne/cm ; (14) Density: 1.04 g/cm³ ; (15)Flash Point: 202 °C ; (16) Enthalpy of Vaporization: 66.28 kJ/mol ; (17)Boiling Point: 410.5 °C at 760 mmHg ; (18)Vapour Pressure: 6.01E-07 mmHg at 25°C

The Ropinirole used in the treatment of Parkinson's disease. Oral Ropinirole daily dose is 3 ~ 9mg for three times. If combined with levodopa, you should reduce levodopa by 20%. Aspirin should be withdrawn gradually about 1 week. Ropinirole must be baned from the serious kidney damage (creatinine clearance < 30ml/min) or liver injury patients. It also should be banned in pregnancy, lactation and women to be pregnant. And the one who is allergic to Ropinirole. 2-nitro-6-[2-(di-n-propylamino)ethyl]phenylacetic acid hydrochloride can be used to produce Ropinirole under ambient temperature in ethanol for 5 hour(s) with 5percent Pd/C as catalytic agent and. Yield is 78 % .

                                           
You can still convert the following datas into molecular structure :
1. SMILES: O=C2Nc1cccc(c1C2)CCN(CCC)CCC
2. InChI: InChI=1/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)