Roxithromycin

The IUPAC name of Roxithromycin is (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one. With the CAS registry number 80214-83-1, it is also named as Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime). The product's categories are Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; Veterinary Medicine, Soluble Powder; Peptide Synthesis/Antibiotics. Besides, it is white crystalline powder, which should be stored at 2-8 °C. In addition, its molecular formula is C₄₁H₇₆N₂O₁₅ and molecular weight is 837.05.When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice.
 

The other characteristics of Roxithromycin can be summarized as:
 (1)ACD/LogP: 3.73; (2)# of Rule of 5 Violations: 3; (3)#H bond acceptors: 17; (4)#H bond donors: 5; (5)#Freely Rotating Bonds: 18; (6)Polar Surface Area: 161.89 Å²; (7)Index of Refraction: 1.535; (8)Molar Refractivity: 207.49 cm³; (9)Molar Volume: 666.3 cm³; (10)Polarizability: 82.25×10^-24cm³; (11)Surface Tension: 39.7 dyne/cm; (12)Density: 1.25 g/cm³; (13)Flash Point: 476.7 °C; (14)Enthalpy of Vaporization: 142.8 kJ/mol; (15)Boiling Point: 864.7 °C at 760 mmHg; (16)Vapour Pressure: 7.17E-35 mmHg at 25 °C.

Preparation of Roxithromycin:
This chemical can be prepared by erythromycin. The reaction is as follows:


Uses of Roxithromycin:
This chemical is a semi-synthetic macrolide antibiotic that is used for the treatment of respiratory tract, urinary and soft tissue infections. It can also be used to prevent bacteria from growing, by interfering with their protein synthesis.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C3O[C@H](CC)[C@](O)(C)[C@H](O)[C@H](C(=NOCOCCOC)[C@H](C)C[C@](O)(C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]([C@H](O[C@@H]2O[C@H]([C@H](O)[C@](OC)(C2)C)C)[C@H]3C)C)C
(2)InChI: InChI=1/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1
(3)InChIKey: RXZBMPWDPOLZGW-HITVVWEBBY

The toxicity data of Roxithromycin is as follows: