-
Name
Riodipine
- EINECS
- CAS No. 71653-63-9
- Article Data4
- CAS DataBase
- Density 1.242g/cm3
- Solubility
- Melting Point 157°C
- Formula C18H19 F2 N O5
- Boiling Point 445.4°C at 760 mmHg
- Molecular Weight 367.349
- Flash Point 223.2°C
- Transport Information
- Appearance
- Safety Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F− and NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 3,5-Pyridinedicarboxylicacid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-, dimethyl ester(9CI);Foridon;Foridone;PP 1466;Riodipine;
- PSA 73.86000
- LogP 3.19760
Ryodipine Chemical Properties
Ryodipine with CAS register number of 71653-63-9 is also called as Riodipine ; Foridon ; Riodipinum ; Foridone ; Phoridone ; Riodipino ; Riodipinum [Latin] ,and so on.
IUPAC Name: Dimethyl-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS: 71653-63-9
Molecular Formula: C18H19F2NO5
Molecular Weight: 367.344
Molecular structure: 
ACD/LogD (pH 5.5): 3.33
ACD/LogD (pH 7.4): 3.33
ACD/BCF (pH 5.5): 199.65
ACD/BCF (pH 7.4): 200.14
ACD/KOC (pH 5.5): 1541.1
ACD/KOC (pH 7.4): 1544.89
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 7
Index of Refraction: 1.509
Molar Refractivity: 88.32 cm3
Molar Volume: 295.7 cm3
Polarizability: 35.01×10-24cm3
Surface Tension: 36.5 dyne/cm
Density: 1.242 g/cm3
Flash Point: 223.2 °C
Enthalpy of Vaporization: 70.34 kJ/mol
Boiling Point: 445.4 °C at 760 mmHg
Vapour Pressure: 3.97E-08 mmHg at 25°C
Ryodipine Uses
Ryodipine (CAS No.71653-63-9) is mainly used as a calcium channel blocker.
Ryodipine Toxicity Data With Reference
| 1. | orl-rat LD50:11 g/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 35 (1985),672. | ||
| 2. | orl-mus LD50:721 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 35 (1985),672. | ||
| 3. | ipr-mus LD50:395 mg/kg | PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 16 (1982),817. | ||
| 4. | orl-dog LD50:1198 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 35 (1985),915. | ||
| 5. | orl-rbt LD50:209 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 35 (1985),915. |
Ryodipine Safety Profile
Ryodipine (CAS No.71653-63-9) is poisonous by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F− and NOx.
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