Salidroside supplier | CasNO.10338-51-9

Name
Salidroside
EINECS 306-819-2
CAS No. 10338-51-9
Article Data25
CAS DataBase
Density 1.46 g/cm³
Solubility
Melting Point 159～160℃
Formula C₁₄H₂₀O₇
Boiling Point 549.5 °C at 760 mmHg
Molecular Weight 300.309
Flash Point 286.2 °C
Transport Information
Appearance Red-brown fine powder
Safety 26
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Rhodiola roseal.P.E;b-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl;Glucopyranoside,p-hydroxyphenethyl (7CI);Salidroside (8CI);2-(4-Hydroxyphenyl)ethyl-b-D-glucopyranoside;4-Hydroxy-phenyl-2-ethyl-b-D-glucopyranoside;Rhodioloside;Rhodosin;Tyrosol a-(b-D-glucopyranoside);
PSA 119.61000
LogP -1.24880

Synthetic route

: 28251-63-0
tetraacetyl salidroside

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With methanol; potassium carbonate	100%
With sodium methylate In methanol at 20℃; for 2h;	89.8%
With sodium methylate In methanol for 12h;	80%
With methanol; sodium methylate at 20℃; for 24h; Large scale reaction;	3.83 kg

: 39032-08-1
(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(4-acetoxyphenethoxy)tetrahydro-2Hpyran-3,4,5-triyl triacetate

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With sodium methylate In methanol for 1h; Ambient temperature;	97.7%
With sodium methylate In methanol at 4℃;	90%
With strongly acidic cation exchange resin 717 In ethanol at 70℃;	86.5%

: 492-61-5
β-D-glucose

: 501-94-0
p-hydroxyphenethyl alcohol

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With E.coli (BLPad-StyAB-RostyC-SlPAR1-UGT85A1) In aq. phosphate buffer at 37℃; for 12h; pH=7.0; Reagent/catalyst; Enzymatic reaction;	94.9%
With β-glycosidase from black plum seeds; 1-octyl-3-methylimidazolium hexafluorophosphate In 1,4-dioxane; aq. phosphate buffer at 50℃; for 72h; pH=5.9; Kinetics; Reagent/catalyst; Solvent; pH-value; Enzymatic reaction;	24.3%
With Prunus domestica prune seed meal at 50℃; for 72h; pH=6; aq. phosphate buffer; Ionic liquid; Enzymatic reaction;	22%

: 183209-56-5
2-(4-benzyloxyphenyl)ethyl β-D-glucopyranoside

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In methanol at 20℃; Darkness; Green chemistry;	93%
With 5% Pd(II)/C(eggshell); ammonium formate In methanol for 6h; Reflux;	91%

: C34H50O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol at 20℃; for 5h;	89.3%

: C37H48O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With potassium ethoxide In ethanol at 20℃; for 5h;	86.7%

: C41H56O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃; for 5h;	86.7%

: C38H58O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; for 5h;	85%

: C46H42O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 5h;	84%

: C35H52O12

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 5h;	81.3%

: 133-99-3, 490-37-9, 2152-98-9, 4482-75-1, 5965-66-2, 13299-27-9, 13360-52-6, 14641-93-1, 15548-43-3, 16462-44-5, 16984-36-4, 16984-38-6, 20869-27-6, 22688-72-8, 27452-49-9, 29276-55-9, 30608-12-9, 34481-13-5, 37169-60-1, 37169-64-5, 64234-01-1, 64234-02-2, 75281-88-8, 80446-85-1, 84413-57-0, 92344-56-4, 93221-87-5, 93301-77-0, 94799-29-8, 100427-98-3, 100428-00-0, 101312-82-7, 102046-24-2, 102046-25-3, 109432-00-0, 109432-02-2, 109432-04-4, 109432-08-8, 135268-49-4, 138231-26-2, 140461-59-2, 145414-22-8, 145414-26-2, 146339-75-5, 146339-76-6, 149116-55-2, 528-50-7
Cellobiose

: 501-94-0
p-hydroxyphenethyl alcohol

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With Pyrococcus furiosus β-glucosidase/gelatin-gel at 70℃; for 12h; pH=5; citrate buffer; Enzymatic reaction;	58%
With β-glucosidase from Aspergillus niger In water at 37℃; for 3h; pH-value; Concentration; Enzymatic reaction;	6.7%
With β-glucosidase from A. niger In water at 37℃; for 3h;

: 501-94-0
p-hydroxyphenethyl alcohol

: 153-18-4
rutin

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With α-L-rhamnosyl-β-D-glucosidase from Aspergillus niger In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 24h; pH=5; Enzymatic reaction; regioselective reaction;	49%

: 501-94-0
p-hydroxyphenethyl alcohol

: 5391-18-4, 25320-93-8, 39824-09-4, 95531-15-0, 143289-25-2, 146453-36-3, 148347-27-7
n-butyl β-D-glucopyranoside

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With Prunus dulcis var. amara β-glucoside glucohydrolase, 68 kDa In aq. phosphate buffer; tert-butyl alcohol at 50℃; for 8h; pH=7; Kinetics; Solvent; pH-value; Temperature; Enzymatic reaction;	39.04%

: 501-94-0
p-hydroxyphenethyl alcohol

: 2492-87-7
4-nitrophenyl-β-D-glucoside

: 10338-51-9
Salidroside

Conditions

Conditions	Yield
With phosphate buffer; β-glucosidase at 30℃; for 26h;	36%

: 67-56-1
methanol

: 40661-45-8
cornoside

A: 10338-51-9
Salidroside

B: 101489-37-6
(2R,3R,4S,5S,6R)-2-[2-(1-Hydroxy-4,4-dimethoxy-cyclohexyl)-ethoxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

C: 123563-44-0
rengyoside B

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 80℃; under 7600 Torr; for 6h;	A 34% B 21% C 23%

...Expand

: 40661-45-8
cornoside

A: 10338-51-9
Salidroside

B: 101489-37-6
(2R,3R,4S,5S,6R)-2-[2-(1-Hydroxy-4,4-dimethoxy-cyclohexyl)-ethoxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

C: 123563-44-0
rengyoside B

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 80℃; under 7600 Torr; for 6h;	A 34% B 21% C 23%

...Expand

Salidroside Specification

The Salidroside with CAS registry number of 10338-51-9 is also known as b-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl. The IUPAC name is (2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol. It belongs to product categories of Plant Oils, Toxins, Phenolic Acids & Derivatives; Nutritional Supplements; Functional Products. In addition, the formula is C₁₄H₂₀O₇ and the molecular weight is 300.31. This chemical is a red-brown fine powder.

Physical properties about Salidroside are: (1)ACD/LogP: -1.23; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.23; (4)ACD/LogD (pH 7.4): -1.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 5.08; (8)ACD/KOC (pH 7.4): 5.07; (9)#H bond acceptors: 7; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.628; (13)Molar Refractivity: 72.79 cm³; (14)Molar Volume: 204.9 cm³; (15)Surface Tension: 77.6 dyne/cm; (16)Density: 1.46 g/cm³; (17)Flash Point: 286.2 °C; (18)Enthalpy of Vaporization: 87.28 kJ/mol; (19)Boiling Point: 549.5 °C at 760 mmHg; (20)Vapour Pressure: 6.54E-13 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O
2. Isomeric SMILES: C1=CC(=CC=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O
3. InChI: InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
4. InChIKey: ILRCGYURZSFMEG-RKQHYHRCSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	subcutaneous	28600uL/kg (28.6mL/kg)		Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 229, 1988.

Product Name

Salidroside

Synthetic route

Salidroside Specification

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