• Name

  Methotrexate disodium salt

• EINECS 231-022-0
• CAS No. 7413-34-5
• Article Data4
• CAS DataBase
• Density
• Solubility Soluble in water
• Melting Point
• Formula C₂₀H₂₀N₈Na₂O₅
• Boiling Point 823℃
• Molecular Weight 498.409
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodiumsalt, L-(+)- (8CI);L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt(9CI);Amethopterin sodium;Methotrexate Lederle;Methotrexate disodium salt;Metotrexato Lederle;
• PSA 216.20000
• LogP -0.84770

Synthetic route

1379609-57-0

dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate

7413-34-5

disodium methotrexate

Conditions

Conditions	Yield
Stage #1: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate With water; potassium hydroxide In methanol at 20℃; for 0.333333h; Stage #2: With hydrogenchloride In methanol; water pH=4.2; Stage #3: With sodium hydroxide In water for 0.0833333h; pH=10;	89%

59-05-2

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

7413-34-5

disodium methotrexate

Conditions

Conditions	Yield
With sodium hydroxide In water
With sodium hydroxide In methanol at 40℃; for 2h;

N-[4-(methylamino)benzoyl]-L-glutamic acid disodium

7413-34-5

disodium methotrexate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C 2.1: water / 1 h / 58 - 62 °C / pH 2.4 3.1: potassium hydroxide; water / methanol / 0.33 h / 20 °C 3.2: pH 4.2 3.3: 0.08 h / pH 10 View Scheme

143-15-7

1-dodecylbromide

7413-34-5

disodium methotrexate

86669-30-9

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid didodecyl ester

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h;	98%

7413-34-5

disodium methotrexate

20443-98-5

2,6-Dichlorobenzyl bromide

86669-36-5

bis(2,6-dichlorobenzyl) methotrexate

Conditions

Conditions	Yield
In dimethyl sulfoxide for 3h; Ambient temperature;	64%

1585-16-6

2-chloromethyl-1,3,5-trimethylbenzene

7413-34-5

disodium methotrexate

86669-35-4

bis(2,4,6-trimethylbenzyl) methotrexate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide for 24h; Ambient temperature;	49%

109-65-9

1-bromo-butane

7413-34-5

disodium methotrexate

50602-77-2

di-n-butyl methotrexate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide

111-25-1

1-bromo-hexane

7413-34-5

disodium methotrexate

50602-79-4

C32H46N8O5

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide

111-83-1

1-bromo-octane

7413-34-5

disodium methotrexate

50602-80-7

di-n-octyl methotrexate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide

Sodium methotrexate Chemical Properties

Sodium methotrexate Toxicity Data With Reference

Sodium methotrexate Safety Profile