Sodium thioglycolate

The CAS registry number of Sodium thioglycolate is 367-51-1. Its EINECS registry number is 206-696-4. The IUPAC name is sodium 2-sulfanylacetate. In addition, the molecular formula is C₂H₄NaO₂S and the molecular weight is 115.10. It is also called acetic acid, mercapto-, monosodium salt. What's more, it is a kind of white solid and should be stored in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: 0.09; (2)ACD/LogD (pH 5.5): -2; (3)ACD/LogD (pH 7.4): -3.47; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 62.6 Å²; (12)Flash Point: 99.8 °C; (13)Enthalpy of Vaporization: 50.9 kJ/mol; (14)Boiling Point: 225.5 °C at 760 mmHg; (15)Vapour Pressure: 0.0314 mmHg at 25°C.

Preparation of Sodium thioglycolate: it can be prepared by thioethanolate. Cool the thioethanolate to 5 °C at first. Then add sodium hydroxide solution into the thioethanolate slowly with stirring. When the solution becomes pink and separates stable crystallization, you can stop adding the sodium hydroxide. At last, after a series of cooling, filtration, crystallization and drying you can get the desired product. The equation is as follows:

Uses of Sodium thioglycolate: it can be used as analytics reagents for the determination of iron, molybdenum, silver and tin. And it can be used in preparation of bacteria culture. In addition, it can react with phenylhydrazono-malononitrile to get [cyano-(phenyl-hydrazono)-acetimidoylsulfanyl]-acetic acid. This reaction will need solvents methanol and H₂O. The reaction time is 2 hours. The pH value of the reaction solution is 7. The yield is about 80%.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear suitable protective clothing. If contact it with skin, wash it immediately with plenty of ... (to be specified by the manufacturer). In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[O-]C(=O)CS
(2)InChI: InChI=1/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
(3)InChIKey: GNBVPFITFYNRCN-REWHXWOFAT

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	500mg/kg (500mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956.
monkey	LDLo	intravenous	300mg/kg (300mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	422mg/kg (422mg/kg)		Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
mouse	LD50	oral	504mg/kg (504mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956.
mouse	LD50	subcutaneous	293mg/kg (293mg/kg)		Japanese Journal of Antibiotics. Vol. 41, Pg. 105, 1988.
mouse	LD50	unreported	8200ug/kg (8.2mg/kg)		Canadian Journal of Technology. Vol. 34, Pg. 21, 1956.
rabbit	LDLo	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 343, 1929.
rat	LD50	intraperitoneal	126mg/kg (126mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 296, 1956.