-
Name
Spiromustine
- EINECS
- CAS No. 56605-16-4
- Article Data1
- CAS DataBase
- Density 1.29g/cm3
- Solubility
- Melting Point 125.5°C
- Formula C14H23 Cl2 N3 O2
- Boiling Point °Cat760mmHg
- Molecular Weight 336.262
- Flash Point °C
- Transport Information
- Appearance
- Safety Poison by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl− and NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 3-[2-[Bis(2-chloroethyl)amino]ethyl]-5,5-pentamethylenehydantoin;NCI 172112; NSC 172112; NSC 268497; SHM; Spirohydantoin mustard; Spiromustine
- PSA 52.65000
- LogP 2.28740
Spiromustine Chemical Properties
IUPAC Name: 3-[2-[Bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
Molecular Formula: C14H23Cl2N3O2
Molecular Weight: 336.30
Freely Rotating Bonds: 7
Polar Surface Area: 43.86 Å2
Index of Refraction: 1.56
Molar Refractivity: 84.1 cm3
Molar Volume: 260 cm3
Polarizability: 33.34 ×10-24 cm3
Surface Tension: 51.6 dyne/cm
Density: 1.29 g/cm3
The Cas Register Number of Spiromustine is 56605-16-4.The chemical synonyms of Spiromustine (CAS NO.56605-16-4) are 1, 3-Diazaspiro[4.5]decane-2,4-dione, 3-[2-[bis (2-chloroethyl)amino]ethyl]- ; 3-(2-(Bis(2-chloroethyl)amino)ethyl)-5,5-pentamethylenehydantoin ; 3-{2-[Bis-(2-chloro-ethyl)-amino]-ethyl}-1,3-diaza-spiro[4.5]decane-2,4-dione .The molecular structure of Spiromustine (CAS NO.56605-16-4) is
.
Spiromustine Uses
Spiromustine (CAS NO.56605-16-4) is used as pharmaceutical intermediate.
Spiromustine Toxicity Data With Reference
| 1. | mma-sat 50 µg/plate | BCPCA6 Biochemical Pharmacology. 32 (1983),523. | ||
| 2. | bfa-mus/sat 60 mg/kg | BCPCA6 Biochemical Pharmacology. 32 (1983),523. | ||
| 3. | ivn-rat LD50:9100 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-149518 . | ||
| 4. | ipr-mus LD50:33,244 µg/kg | NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . | ||
| 5. | ivn-mus LD50:48,280 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-148395 . | ||
| 6. | ivn-dog LDLo:3750 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-149518 . |
Spiromustine Safety Profile
Poison by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl− and NOx.
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