Product Name

  • Name

    Dolasteron

  • EINECS 255-096-9
  • CAS No. 40828-46-4
  • Article Data12
  • CAS DataBase
  • Density 1.29 g/cm3
  • Solubility soluble in water
  • Melting Point 278 °C
  • Formula C14H12O3S
  • Boiling Point 442.598 °C at 760 mmHg
  • Molecular Weight 260.313
  • Flash Point 221.475 °C
  • Transport Information UN 3249
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 40828-46-4 (Dolasteron)
  • Hazard Symbols
  • Synonyms (?à)-Suprofen;2-[4-(Thiophene-2-carbonyl)phenyl]propanoic acid;Masterfen;NSC 303611;Profenal;Profenol;R 25061;Racemic suprofen;Srendam;Sulproltin;Supranol;Suprocil;Suprol;Sutoprofen;TN 762;p-(2-Thenoyl)hydratropic acid;
  • PSA 82.61000
  • LogP 3.16720

Suprofen Chemical Properties

MF: C14H12O3S
MW: 260.30828
EINECS: 255-096
Density: 1.29 g/cm3 
Flash Point: 221.5 °C
Melting Point: 278°C
Water Solubility: soluble
Index of Refraction: 1.612 
Enthalpy of Vaporization: 73.79 kJ/mol 
Boiling Point: 442.6 °C at 760 mmHg 
Vapour Pressure: 1.3E-08 mmHg at 25°C
Stability: Stable at normal temperatures and pressures.
IUPAC Name: 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid
Chemical Properties P-(2-thenoyl)-hydratropicaci (40828-46-4): Off-White to Light-Brown 
Synonyms: Dolasetron ; (+-)-2-(P-(2-thenoyl)phenyl)propionicacid ; Alpha-Methyl-4-(2-thienylcarbonyl)-benzeneaceticaci ; Alpha-methyl-4-(2-thienylcarbonyl)benzeneaceticacid ; Maldocil ; P-(2-thenoyl)-hydratropicaci ; P-(2-thenoyl)hydratropicacid ; R25061
Product Categories: Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals
Following is the molecular structure of P-(2-thenoyl)-hydratropicaci (40828-46-4):

 

Suprofen Uses

Usage of P-(2-thenoyl)-hydratropicaci (40828-46-4): Prostaglandin biosynthesis inhibitor. Analgesic;Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Suprofen Toxicity Data With Reference

1.    

skn-rbt 150 mg/30D-I MLD

     YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 15 (1987),3611.
2.    

orl-man TDLo:8571 µg/kg/4D-I:KID

     DICPBB    Drug Intelligence and Clinical Pharmacy. 20 (1986),860.
3.    

orl-man TDLo:2857 µg/kg:KID

     AIMEAS    Annals of Internal Medicine. 105 (1986),799.
4.    

orl-wmn TDLo:4 mg/kg:KID

     AIMEAS    Annals of Internal Medicine. 106 (1987),235.
5.    

orl-rat LD50:70,600 µg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1526.
6.    

ipr-rat LD50:335 mg/kg

     YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),1005.
7.    

scu-rat LD50:500 mg/kg

     YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),1005.
8.    

orl-mus LD50:590 mg/kg

     DRFUD4    Drugs of the Future. 1 (1976),148.
9.    

ipr-mus LD50:375 mg/kg

     YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),1005.
10.    

scu-mus LD50:710 mg/kg

     YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),1005.

Suprofen Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: changes in kidney tubules, hematuria. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx. Used as an analgesic and anti-inflammatory agent.

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