-
Name
Tiapride hydrochloride
- EINECS 256-908-4
- CAS No. 51012-33-0
- Density 1.15 g/cm3
- Solubility
- Melting Point approximate 200℃ (dec.)
- Formula C15H24 N2 O4 S . Cl H
- Boiling Point 498.1 °C at 760 mmHg
- Molecular Weight 364.894
- Flash Point 255.1 °C
- Transport Information
- Appearance
- Safety Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx, NOx, and HCl.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Benzamide,N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-, monohydrochloride(9CI); Gramalil; Italprid; Luxoben; Sereprile; Tiapridal; Tiapridehydrochloride; Tiapridex
- PSA 84.09000
- LogP 3.44400
TIAPRIDE HYDROCHLORIDE Chemical Properties
UPAC Name: N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonylbenzamide hydrochloride (51012-33-0)
SynonymsTtiapride hydrochloride ; N-[2-(diethylamino)ethyl]-5-[methyl-sulfonyl]-o-anisamide hydrochloride ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamidehydrochloride ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydroch ; N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydrochloride ; N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulphonyl)benzamide monohydrochloride ; TiapridHCl;Tiapridhydrochlorid
CAS: 51012-33-0
MF: C15H25ClN2O4S
MW: 364.89
MS: 
EINECS: 256-908-4
Mol File: 51012-33-0.mol
Flash Point: 255.1 °C
Enthalpy of Vaporization: 76.63 kJ/mol
Boiling Point: 498.1 °C at 760 mmHg
Vapour Pressure: 4.65E-10 mmHg at 25°C
Storage temp: StoreTiapride hydrochloride (51012-33-0) at 2-8°C.
TIAPRIDE HYDROCHLORIDE Uses
Tiapride hydrochloride (51012-33-0）is antipsychotics.
TIAPRIDE HYDROCHLORIDE Production
Tiapride hydrochloride (51012-33-0）is prepared by reacting 2-methoxy-5-methylsulfonylbenzoic acid (I) with isobutyl chloroformate (A) in dioxane to give the corresponding anhydride (II), which is finally condensed with N,N-diethylethylenediamine (B).
TIAPRIDE HYDROCHLORIDE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| dog | LD50 | oral | 240mg/kg (240mg/kg) | sense organs and special senses: mydriasis (pupillary dilation): eye | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| mouse | LD50 | intraperitoneal | 336mg/kg (336mg/kg) | behavioral: altered sleep time (including change in righting reflex) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| mouse | LD50 | intravenous | 189mg/kg (189mg/kg) | behavioral: altered sleep time (including change in righting reflex) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| mouse | LD50 | oral | 1340mg/kg (1340mg/kg) | behavioral: altered sleep time (including change in righting reflex) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| mouse | LD50 | subcutaneous | 755mg/kg (755mg/kg) | behavioral: altered sleep time (including change in righting reflex) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| rat | LD50 | intraperitoneal | 421mg/kg (421mg/kg) | sense organs and special senses: ptosis: eye | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| rat | LD50 | intravenous | 254mg/kg (254mg/kg) | sense organs and special senses: ptosis: eye | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| rat | LD50 | oral | 4840mg/kg (4840mg/kg) | sense organs and special senses: ptosis: eye | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
| rat | LD50 | subcutaneous | 1130mg/kg (1130mg/kg) | sense organs and special senses: ptosis: eye | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985. |
TIAPRIDE HYDROCHLORIDE Safety Profile
WGK Germany: 2
RTECS: CV4203800
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