-
Name
TRIETHYLENEMELAMINE
- EINECS 200-083-5
- CAS No. 51-18-3
- Density 1.617g/cm3
- Solubility negligible
- Melting Point 160 °C
- Formula C9H12 N6
- Boiling Point 430.2°Cat760mmHg
- Molecular Weight 204.234
- Flash Point 214°C
- Transport Information
- Appearance white powder
- Safety Poison by ingestion, intraperitoneal, intramuscular, intravenous, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Human mutation data reported. Can cause gastrointestinal tract disturbances and bone marrow depression. When heated to decomposition it emits highly toxic fumes of NOx. Used as an antineoplastic agent and as an insect sterilant.
- Risk Codes R28;R40;
-
Molecular Structure
- Hazard Symbols Highly toxic.
- Synonyms s-Triazine,2,4,6-tris(1-aziridinyl)- (8CI); 2,4,6-Triethylenimino-s-triazine;2,4,6-Tris(1-aziridinyl)-1,3,5-triazine; 2,4,6-Tris(1-aziridinyl)-s-triazine;2,4,6-Tris(ethyleneimino)-s-triazine; 2,4,6-Tris(ethylenimino)-s-triazine; DRP859025; ENT 25296; M 9500; NSC 9706; Persistol; Persistol Ho 1/193; PersistolHoe 1/193; R 246; SK 1133; TAT; TEM; TEM (cytostatic); TET; Tem-Simes;Tretamin; Tretamine; Triamelin; Triaziridinyl triazine; Triethanomelamine;Triethylenemelamine; Tris(ethyleneimino)triazine; Trisaziridinyltriazine
- PSA 47.70000
- LogP -0.47340
TRISAZIRIDINYLTRIAZINE Chemical Properties
Product Name: Triaziridinyl triazine (CAS NO.51-18-3)
Molecular Formula: C9H12N6
Molecular Weight: 204.23g/mol
Mol File: 51-18-3.mol
Einecs: 200-083-5
Appearance: White powder
Melting Point: 160 °C
Boiling point: 430.2 °C at 760 mmHg
Storage Temperature: Refrigerator (+4°C) + Poison room
Flash Point: 214 °C
Density: 1.617 g/cm3
Water Solubility: Negligible
Stability: Stability Unstable - polymerizes at room temperature. Polymerizes more readily if heated and in the presence of moisture
Surface Tension: 119.6 dyne/cm
Enthalpy of Vaporization: 68.57 kJ/mol
Vapour Pressure: 1.32E-07 mmHg at 25°C
XLogP3-AA: 0.7
H-Bond Donor: 0
H-Bond Acceptor: 6
TRISAZIRIDINYLTRIAZINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 2870ug/kg (2.87mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| cat | LDLo | intravenous | 1mg/kg (1mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. | |
| dog | LDLo | intravenous | 400ug/kg (0.4mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. | |
| dog | LDLo | oral | 1mg/kg (1mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. | |
| monkey | LDLo | intravenous | 100ug/kg (0.1mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: LEUKOPENIA BLOOD: OTHER CHANGES | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 202, 1965. |
| mouse | LD50 | intramuscular | 1500ug/kg (1.5mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | intraperitoneal | 2800ug/kg (2.8mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. |
| mouse | LD50 | oral | 15mg/kg (15mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. |
| mouse | LD50 | subcutaneous | 1871ug/kg (1.871mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| mouse | LDLo | intravenous | 4mg/kg (4mg/kg) | BLOOD: LEUKOPENIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) | California Medicine. Vol. 75, Pg. 26, 1951. |
| quail | LD50 | oral | 133mg/kg (133mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
| rat | LD50 | intracrebral | > 400ug/kg (0.4mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 18, Pg. 760, 1966. | |
| rat | LD50 | intramuscular | 1500ug/kg (1.5mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rat | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. |
| rat | LD50 | intravenous | 1110ug/kg (1.11mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 539, 1956. | |
| rat | LD50 | oral | 13mg/kg (13mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950. | |
| rat | LDLo | unreported | 5mg/kg (5mg/kg) | Gann. Japanese Journal of Cancer Research. Vol. 43, Pg. 171, 1952. |
TRISAZIRIDINYLTRIAZINE Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 ,1975,p. 95.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
TRISAZIRIDINYLTRIAZINE Safety Profile
Poison by ingestion, intraperitoneal, intramuscular, intravenous, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Human mutation data reported. Can cause gastrointestinal tract disturbances and bone marrow depression. When heated to decomposition it emits highly toxic fumes of NOx. Used as an antineoplastic agent and as an insect sterilant.
TRISAZIRIDINYLTRIAZINE Specification
Triaziridinyl triazine ,its CAS NO. is 51-18-3,the synonyms is 1,1',1''-s-Triazine-2,4,6-triyltrisaziridine ; 1,1',1"-s-Triazine-2,4,6-triyltris-aziridin ; 1,1',1"-s-Triazine-2,4,6-triyltrisaziridine ; 1,3,5-Triazine, 2,4,6-tris(1-aziridinyl)- ; 2,4,6-Tri(1-aziridinyl)-1,3,5-triazine ; 2,4,6-Tri(ethyleneimino)-1,3,5-triazine ; 2,4,6-Tri(ethyleneimino)-s-triazine ; 2,4,6-Tri(ethylenimino)-1,3,5-triazine .
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