Product Name

  • Name

    Testosterone enanthate

  • EINECS 206-253-5
  • CAS No. 315-37-7
  • Article Data10
  • CAS DataBase
  • Density 1.06 g/cm3
  • Solubility
  • Melting Point 34-39 °C
  • Formula C26H40O3
  • Boiling Point 503.9 °C at 760 mmHg
  • Molecular Weight 400.602
  • Flash Point 214.2 °C
  • Transport Information
  • Appearance White crystalline powder
  • Safety 53-22-36/37/39-45
  • Risk Codes 45-63
  • Molecular Structure Molecular Structure of 315-37-7 (Testosterone enanthate)
  • Hazard Symbols ToxicT
  • Synonyms Testosterone,heptanoate (6CI,8CI);Heptanoic acid, ester with testosterone (6CI);17b-Enanthoxyandrost-4-en-3-one;17b-Hydroxyandrost-4-en-3-one enanthate;4-Androsten-3-one17b-enanthate;Andro LA 200;Androtardyl;Delatestryl;Everone;NSC 17591;Primoteston-Depot;Reposo TMD;Testenate;Testinon;Testo-Enant;Testosterone 17-enanthate;Testosterone heptylate;Testosterone oenanthate;
  • PSA 43.37000
  • LogP 6.40050

Synthetic route

oenanthic acid
111-14-8

oenanthic acid

17β-hydroxy-3-methoxyandrosta-3,5-diene

17β-hydroxy-3-methoxyandrosta-3,5-diene

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Stage #1: oenanthic acid; 17β-hydroxy-3-methoxyandrosta-3,5-diene With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water		97.18%
oenanthic acid
111-14-8

oenanthic acid

17β-hydroxy-3-ethoxyandrosta-3,5-diene
26614-48-2

17β-hydroxy-3-ethoxyandrosta-3,5-diene

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Stage #1: oenanthic acid; 17β-hydroxy-3-ethoxyandrosta-3,5-diene With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
Stage #2: With sulfuric acid In water		96.3%
oenanthic acid
111-14-8

oenanthic acid

3,3-(ethylenedioxy)-5-androsten-17β-ol
975-57-5

3,3-(ethylenedioxy)-5-androsten-17β-ol

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Stage #1: oenanthic acid; 3,3-(ethylenedioxy)-5-androsten-17β-ol With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
Stage #2: With sulfuric acid In water		95.76%
oenanthic acid
111-14-8

oenanthic acid

testosterone
58-22-0

testosterone

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Stage #1: oenanthic acid; testosterone With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
Stage #2: With sulfuric acid In water		89.6%
testosterone
58-22-0

testosterone

Heptanoic acid chloride
2528-61-2

Heptanoic acid chloride

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
With pyridine Ambient temperature;57%
With dmap; triethylamine In dichloromethane at 20℃;11.9 g
3-ethoxyandrosta-3,5-dien-17-one
972-46-3

3-ethoxyandrosta-3,5-dien-17-one

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium borohydride; pyridine / ethanol / 60 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: potassium borohydride; pyridine / ethanol / 60 °C
2: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: potassium borohydride; pyridine / ethanol / 60 °C
2: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
3: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
17β-hydroxy-3-ethoxyandrosta-3,5-diene
26614-48-2

17β-hydroxy-3-ethoxyandrosta-3,5-diene

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
2: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
testosterone
58-22-0

testosterone

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine hydrochloride / ethanol / 40 °C / Inert atmosphere
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Androstenedione
63-05-8

Androstenedione

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridinium p-toluenesulfonate / methanol / 20 °C / Inert atmosphere
2: pyridine; sodium tetrahydroborate / methanol / 40 °C
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: pyridinium p-toluenesulfonate / ethanol / 40 °C / Inert atmosphere
2: potassium borohydride; pyridine / ethanol / 60 °C
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: pyridinium p-toluenesulfonate / ethanol / 40 °C / Inert atmosphere
2: potassium borohydride; pyridine / ethanol / 60 °C
3: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: pyridinium p-toluenesulfonate / ethanol / 40 °C / Inert atmosphere
2: potassium borohydride; pyridine / ethanol / 60 °C
3: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C
4: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere
5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
View Scheme
3-methoxyandrosta-3,5-dien-17-one
57144-06-6

3-methoxyandrosta-3,5-dien-17-one

testosterone heptanoate
315-37-7

testosterone heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; sodium tetrahydroborate / methanol / 40 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 40 °C / Inert atmosphere
View Scheme
testosterone heptanoate
315-37-7

testosterone heptanoate

A

testosterone
58-22-0

testosterone

B

Androstenedione
63-05-8

Androstenedione

C

6β-hydroxytestosterone
62-99-7, 2944-87-8, 34096-63-4, 34442-08-5, 145772-79-8

6β-hydroxytestosterone

Conditions
ConditionsYield
With Fusarium fujikuroi PTCC 5144 In ethanol; water at 26℃; for 312h; Reagent/catalyst; Microbiological reaction;A 20%
B 17%
C 59%
...Expand
testosterone heptanoate
315-37-7

testosterone heptanoate

A

testosterone
58-22-0

testosterone

B

6β-hydroxytestosterone
62-99-7, 2944-87-8, 34096-63-4, 34442-08-5, 145772-79-8

6β-hydroxytestosterone

C

14alpha-Hydroxytestosterone
4075-20-1

14alpha-Hydroxytestosterone

Conditions
ConditionsYield
With Acremonium chrysogenu PTCC 5271 In ethanol; water at 26℃; for 72h; Reagent/catalyst; Microbiological reaction;A 12%
B 29%
C 53%
...Expand
2,2,3,3,3-pentafluoropropanoic anhydride
356-42-3

2,2,3,3,3-pentafluoropropanoic anhydride

testosterone heptanoate
315-37-7

testosterone heptanoate

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,3,3,3-pentafluoro-propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,3,3,3-pentafluoro-propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;
N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide
24589-78-4

N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide

testosterone heptanoate
315-37-7

testosterone heptanoate

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
With ammonium iodide; 1,4-dithio-erythritol at 60℃; for 0.25h;
testosterone heptanoate
315-37-7

testosterone heptanoate

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,2-trifluoro-acetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Heptanoic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-(2,2,2-trifluoro-acetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;
testosterone heptanoate
315-37-7

testosterone heptanoate

heptafluorobutyric anhydride
336-59-4

heptafluorobutyric anhydride

Heptanoic acid (8R,9S,10R,13S,14S,17S)-3-(2,2,3,3,4,4,4-heptafluoro-butyryloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Heptanoic acid (8R,9S,10R,13S,14S,17S)-3-(2,2,3,3,4,4,4-heptafluoro-butyryloxy)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
at 70℃; for 0.25h;
testosterone heptanoate
315-37-7

testosterone heptanoate

Heptanoic acid (8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl ester

Heptanoic acid (8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In acetic acid for 1h; Ambient temperature;
testosterone heptanoate
315-37-7

testosterone heptanoate

3-oxo-5α-androstan-17β-yl heptanoate
33776-88-4

3-oxo-5α-androstan-17β-yl heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / PtO2 / acetic acid / 1 h / Ambient temperature
2: Jones reagent / acetone / 0.08 h
View Scheme
testosterone heptanoate
315-37-7

testosterone heptanoate

3-oxo-5β-androstan-17β-yl heptanoate

3-oxo-5β-androstan-17β-yl heptanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / PtO2 / acetic acid / 1 h / Ambient temperature
2: Jones reagent / acetone / 0.08 h
View Scheme
testosterone heptanoate
315-37-7

testosterone heptanoate

testosterone
58-22-0

testosterone

Conditions
ConditionsYield
With Candida antarctica Lipase A In aq. phosphate buffer at 20℃; for 20h; pH=8; Reagent/catalyst; Enzymatic reaction;

Testosterone enanthate Chemical Properties

Empirical Formula: C26H40O3
Molecular Weight: 400.594
Nominal Mass: 400 Da
Average Mass: 400.594 Da
Monoisotopic Mass: 400.297745 Da 
Index of Refraction: 1.528
Molar Refractivity: 115.85 cm3
Molar Volume: 375.8 cm3
Surface Tension: 41.2 dyne/cm
Density: 1.06 g/cm3
Flash Point: 214.2 °C
Enthalpy of Vaporization: 77.33 kJ/mol
Boiling Point: 503.9 °C at 760 mmHg
Vapour Pressure: 2.79E-10 mmHg at 25 °C
Melting point: 34-39 °C
Storage tempreture: 2-8 °C
Sensitive: White crystalline powder
Appearance: Colorless crystalline powder
Structure of Testosterone heptanoate (CAS NO.315-37-7):
                       
IUPAC Name: [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] heptanoate
Canonical SMILES: CCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Isomeric SMILES: CCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
InChI: InChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1
InChIKey: VOCBWIIFXDYGNZ-IXKNJLPQSA-N
Product Category of Testosterone heptanoate (CAS NO.315-37-7): Steroids

Testosterone enanthate Uses

 Testosterone heptanoate (CAS NO.315-37-7) can be used for clinical hypothyroidism for the men, aplastic anemia, etc..

Testosterone enanthate Toxicity Data With Reference

1.    

ims-rbt TDLo:409 mg/kg/2Y-I:ETA,TER

     CNREA8    Cancer Research. 26 (1966),474.
2.    

ims-man TDLo:7519 mg/kg/5W-I:PUL

     NEJMAG    New England Journal of Medicine. 308 (1983),508.
3.    

ipr-rat LD50:2000 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),486.
4.    

ipr-mus LD50:4 mg/kg CLDND*

Testosterone enanthate Consensus Reports

EPA Genetic Toxicology Program.

Testosterone enanthate Safety Profile

Poison by intraperitoneal route. Human systemic effects by ingestion: dyspnea. Human reproductive effects by ingestion, intramuscular, and parenteral routes: changes in spermatogenesis and paternal effects to testes, epididymis, and sperm duct. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic and teratogenic data. When heated to decomposition it emits acrid smoke and irritating fumes. A drug used to treat hypogonadism and metastatic breast cancer. See also TESTOSTERONE.
Hazard Codes: ToxicT
Risk Statements: 45-63
 R45:May cause cancer. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 53-22-36/37/39-45 
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use.

Testosterone enanthate Specification

 Testosterone heptanoate , its cas register number is 315-37-7. It also can be called Testosterone enanthate ; 17-((1-Oxoheptyl)oxy)androst-4-en-3-one ; and 17b-Hydroxyandrost-4-en-3-one-17-ethanate .

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