Product Name

  • Name

    Thalicarpine

  • EINECS
  • CAS No. 5373-42-2
  • Article Data9
  • CAS DataBase
  • Density 1.194g/cm3
  • Solubility
  • Melting Point 160-161°
  • Formula C41H48 N2 O8
  • Boiling Point 762.2°Cat760mmHg
  • Molecular Weight 696.841
  • Flash Point 181.4°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 5373-42-2 (Thalicarpine)
  • Hazard Symbols
  • Synonyms 4H-Dibenzo[de,g]quinoline,9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-,[S-(R*,R*)]-; 6aa-Aporphine,9-[[4,5-dimethoxy-a-((S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2,10-trimethoxy-(8CI); Thalicarpine (7CI); (+)-Thalicarpine; NSC 68075; Taliblastine;Thaliblastine; Thalicarpin
  • PSA 80.32000
  • LogP 6.93870

Thalicarpine Chemical Properties

 IUPAC Name; [S-(R*,R*)]-9-[4,5-Dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline 
Molecular Formula: C41H48N2O8
Molecular Weight: 696.91
Density: 1.194g/cm3
Melting Point: 160–161°C
Boiling Point: 762.2°C at 760mmHg
Flash Point: 181.4°C
Properties: needles or crystals from EtOH (aq) or Et2O 
Freely Rotating Bonds: 11
Polar Surface Area: 80.32 Å2
Index of Refraction: 1.589
Molar Refractivity: 196.9 cm3
Molar Volume: 583.5 cm3
Polarizability: 78.06 ×10-24 cm3
Surface Tension: 44.3 dyne/cm
Enthalpy of Vaporization: 111.01 kJ/mol
Vapour Pressure: 3.91E-23 mmHg at 25°C
The Cas Register Number  of Thalicarpine is 5373-42-2.The chemical synonyms of Thalicarpine (CAS NO.5373-42-2) are (6aS)-9-(2-{[(1S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-4,5-dimethoxyphenoxy)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline ; 4H-dibenzo[de,g]quinoline, 9-[4,5-dimethoxy-2-[[(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)- ; (6aS)-9-(2-{[(1S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-4,5-dimethoxyphenoxy)-1,2,10-trimethoxyaporphine ; 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-9-(4,5-dimethoxy-2-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)-1,2,10-trimethoxy-6-methyl- ;   4H-Dibenzo[de,g]quinoline, 5,6,6a, 7-tetrahydro-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-1,2, 10-trimethoxy-6-methyl- ; 6a.alpha.-Aporphine, 9-[[4, 5-dimethoxy-.alpha.- (1.beta.,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2, 10-trimethoxy- ; 6a.alpha.-Aporphine, 9-[[4,5-dimethoxy-.alpha.-((S)-1,2,3, 4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1, 2,10-trimethoxy- ; 6aalpha-Aporphine, 9-((4,5-dimethoxy-alpha-(1beta,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl)oxy)-1,2,10-trimethoxy- (8CI) ; Taliblastin ; Taliblastine  .The molecular structure of Thalicarpine (CAS NO.5373-42-2) is.

Thalicarpine Uses

 Thalicarpine (CAS NO.5373-42-2) is used in organic synthesis.

Thalicarpine Toxicity Data With Reference

1.    

dni-rat:leu 20 mg/L

     MUREAV    Mutation Research. 147 (1985),303.
2.    

dnd-mam:lym 125 µg/L

     JPMSAE    Journal of Pharmaceutical Sciences. 63 (1974),474.
3.    

orl-rat LD50:1500 mg/kg

     DBANAD    Doklady Bolgarskoi Akademii Nauk. 28 (1975),709.
4.    

ipr-rat LD50:140 mg/kg

     NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) JAN 86 .
5.    

ivn-rat LD50:78,300 µg/kg

     DBANAD    Doklady Bolgarskoi Akademii Nauk. 28 (1975),709.
6.    

orl-mus LD50:1542 mg/kg

     NCIAL*    Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (Cambridge, MA.: )1969,60.
7.    

ipr-mus LD50:247 mg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 17 (1970),284.
8.    

ivn-mus LD50:43,700 µg/kg

     NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB82-166299 .
9.    

ivn-mky LDLo:42 mg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 22 (1972),304.

Thalicarpine Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

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