1. Introduction of Tiamulin
Tiamulin (55297-95-5), with chemical name of (1S,2R,3S,4S,6R,7S,14R)-6-[(2-Diethylaminoethylthio)acetoxy]-3-hydroxy-2,4,7,14-tetramethyl-4-vinyltricyclo[5,4,3,01.8]tetradecan-9-one, is white to pale yellow crystalline powder. It is soluble in water, 1:16.6, which is stable in the dry powder, not stable to light and heat.
2. Properties of Tiamulin
Tiamulin has the following properties: (1)Surface Tension: 44.8 dyne/cm; (2)Density: 1.1 g/cm3; (3)Flash Point: 294.3 °C; (4)Enthalpy of Vaporization: 97.23 kJ/mol; (5)Boiling Point: 563 °C at 760 mmHg; (6)Vapour Pressure: 5.06E-15 mmHg at 25°C.
3. Structure Descriptors of Tiamulin
You could convert the following datas into the molecular structure:
4. Toxicity of Tiamulin
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | intramuscular | 250mg/kg (250mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
chicken | LD50 | intravenous | 25mg/kg (25mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
chicken | LD50 | oral | 1550mg/kg (1550mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
mammal (species unspecified) | LD50 | oral | 812mg/kg (812mg/kg) | Drugs of the Future. Vol. 2, Pg. 274, 1977. | |
mouse | LD50 | intravenous | 49mg/kg (49mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
mouse | LD50 | oral | 710mg/kg (710mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
mouse | LD50 | subcutaneous | 1020mg/kg (1020mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
rat | LD50 | intravenous | 20mg/kg (20mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
rat | LD50 | oral | 2230mg/kg (2230mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
rat | LD50 | subcutaneous | 4380mg/kg (4380mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
turkey | LD50 | intramuscular | 409mg/kg (409mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
turkey | LD50 | oral | 1345mg/kg (1345mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. |
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