Product Name

  • Name

    TICRYNAFEN

  • EINECS
  • CAS No. 40180-04-9
  • Article Data4
  • CAS DataBase
  • Density 1.532
  • Solubility
  • Melting Point 148-149oC
  • Formula C13H8Cl2O4S
  • Boiling Point 534.6°C at 760 mmHg
  • Molecular Weight 331.176
  • Flash Point 277.1°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, kidney damage and decreased urine volume or anuria. Mutation data reported. Used as a diuretic, uricosuric and antihypertensive. When heated to decomposition it emits toxic fumes of Cl− and SOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 40180-04-9 (TICRYNAFEN)
  • Hazard Symbols
  • Synonyms Tienilic acid;Tienilico acido;Acidum tienilicum;TienilicAcid;Selacryn;Diflurex;Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid;[2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid;Acido tienilico;Acide tienilique;2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid;[2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid;Ticrex;Ticrynafen;2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid;Thienylic acid;
  • PSA 91.84000
  • LogP 3.74930

Tienilic acid Chemical Properties

Product Name: Tienilic acid (CAS NO.40180-04-9)


Molecular Formula: C13H8Cl2O4S
Molecular Weight: 331.1712g/mol
Mol File: 40180-04-9.mol
Boiling point: 534.6 °C at 760 mmHg
Flash Point: 277.1 °C
Density: 1.532 g/cm3
Surface Tension: 59.4 dyne/cm
Enthalpy of Vaporization: 85.34 kJ/mol
Vapour Pressure: 2.94E-12 mmHg at 25°C
XLogP3-AA: 4.1
H-Bond Donor: 1
H-Bond Acceptor: 4

Tienilic acid Uses

  Tienilic acid (CAS NO.40180-04-9) (INN and BAN) or ticrynafen (USAN) is a diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was withdrawn in 1982, shortly after its introduction to the market, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis.

Tienilic acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 3571ug/kg (3.571mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED		 Clinical Toxicology. Vol. 18, Pg. 425, 1981.
man TDLo oral 6666ug/kg (6.666mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" New England Journal of Medicine. Vol. 301, Pg. 1180, 1979.
mouse LD50 intraperitoneal 318mg/kg (318mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Drugs of the Future. Vol. 13, Pg. 257, 1988.
mouse LD50 intravenous 225mg/kg (225mg/kg)   United States Patent Document. Vol. #3758506,
mouse LD50 oral 1275mg/kg (1275mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 625, 1974.
women TDLo oral 5mg/kg (5mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED		 New England Journal of Medicine. Vol. 301, Pg. 1179, 1979.

Tienilic acid Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, kidney damage and decreased urine volume or anuria. Mutation data reported. Used as a diuretic, uricosuric and antihypertensive. When heated to decomposition it emits toxic fumes of Cl− and SOx.

Tienilic acid Specification

 Tienilic acid ,its CAS NO. is 40180-04-9,the synonyms is (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid
 (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid ; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid ; 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure ; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid ; 5-18-02-00008 (Beilstein Handbook Reference) ; ANP 3624 ; Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)- ; Acide tienilique ;  Acidum tienilicum ; Selacryn ; Ticrex ; Ticrynafen .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View