Product Name

  • Name

    Timepidium bromide

  • EINECS
  • CAS No. 35035-05-3
  • Density g/cm3
  • Solubility
  • Melting Point 198-200°
  • Formula C17H22 N O S2 . Br
  • Boiling Point °Cat760mmHg
  • Molecular Weight 400.404
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety Poison by intramuscular, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, SOx, and Br−.
  • Risk Codes
  • Molecular Structure Molecular Structure of 35035-05-3 (Timepidium bromide)
  • Hazard Symbols
  • Synonyms Piperidinium,3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide (9CI);1,1-Dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide; Mepidium;SA 504; SA 50Y; Sesden; Timepidium bromide
  • PSA 65.71000
  • LogP 1.06940

Timepidium bromide Chemical Properties

Molecule structure of Timepidium bromide (CAS NO.35035-05-3) :

IUPAC Name: 3-(dithiophen-2-ylmethylidene)-5-methoxy-1,1-dimethylpiperidin-1-ium bromide 
Molecular Weight: 400.39668 g/mol
Molecular Formula: C17H22BrNOS2
H-Bond Acceptor: 2
Rotatable Bond Count: 3
Exact Mass: 399.032618
MonoIsotopic Mass: 399.032618
Topological Polar Surface Area: 9.2
Heavy Atom Count: 22
Complexity: 390
Canonical SMILES: C[N+]1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C.[Br-]
InChI: InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1
InChIKey: QTSXMEPZSHLZFF-UHFFFAOYSA-M

Timepidium bromide Uses

 Timepidium bromide (CAS NO.35035-05-3) is an anticholinergic. The quaternary nitrogen prevents it from crossing the blood brain barrier, so it is peripherally acting with no central side effects.

Timepidium bromide Toxicity Data With Reference

1.    

orl-rat LD50:1213 mg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 22 (1972),685.
2.    

scu-rat LD50:252 mg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 22 (1972),685.
3.    

ipr-rat LD50:55 mg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 22 (1972),685.
4.    

ivn-rat LD50:7 mg/kg

     OYYAA2    Oyo Yakuri. Pharmacometrics. 23 (1982),461.
5.    

orl-mus LD50:713 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 15 (1972),914.
6.    

ipr-mus LD50:97 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 15 (1972),914.
7.    

scu-mus LD50:145 mg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 22 (1972),685.
8.    

ivn-mus LD50:12 mg/kg

     JJPAAZ    Japanese Journal of Pharmacology. 22 (1972),685.
9.    

ims-mus LD50:199 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),351.

Timepidium bromide Safety Profile

Poison by intramuscular, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, SOx, and Br−.

Timepidium bromide Specification

 Timepidium bromide (CAS NO.35035-05-3) is also called 1,1-Dimethyl-5-methoxy-3-(dithien-2-ylmethylene)-piperidinium bromide ; Bromure de timepidium ; Bromure de timepidium [INN-French] ; Bromuro de timepidio ; Bromuro de timepidio [INN-Spanish] ; N-Methyl-5-methoxy-3-piperidylidenedithienylmethane methobromide ; SA 50 Y ; SA 504 ; Timepidii bromidum ; Timepidii bromidum [INN-Latin] ; UNII-8R9E4766V4 ; 3-(Di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-piperidinium bromide; Piperidinium, 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide . 

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