Product Name

  • Name

    Tinidazole

  • EINECS 243-014-4
  • CAS No. 19387-91-8
  • Article Data15
  • CAS DataBase
  • Density 1.43 g/cm3
  • Solubility
  • Melting Point 117-121°C(lit.)
  • Formula C8H13N3O4S
  • Boiling Point 528.4 °C at 760 mmHg
  • Molecular Weight 247.275
  • Flash Point 273.4 °C
  • Transport Information
  • Appearance solid
  • Safety 26-36
  • Risk Codes 20/21/22-40
  • Molecular Structure Molecular Structure of 19387-91-8 (Tinidazole)
  • Hazard Symbols HarmfulXn
  • Synonyms Imidazole,1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro- (8CI);1-(Ethylsulfonylethyl)-2-methyl-5-nitroimidazole;Bioshik;CP 12574;Fasigin;Fasigyn;Glongyn;Pletil;Simplotan;Sorquetan;Tini 300;
  • PSA 106.16000
  • LogP 2.13840

Synthetic route

1-(2-(ethylthio)ethyl)-2-methyl-5-nitro-1H-imidazole
28795-33-7

1-(2-(ethylthio)ethyl)-2-methyl-5-nitro-1H-imidazole

tinidazole
19387-91-8

tinidazole

Conditions
ConditionsYield
With oxygen; uranyl(VI) acetate dihydrate In o-xylene; water; acetonitrile at 20℃; under 760.051 Torr; Schlenk technique; Irradiation;70%
With sodium molybdate; dihydrogen peroxide at 50 - 65℃; Large scale;53.9%
2,2'-thiobis-ethanol
111-48-8

2,2'-thiobis-ethanol

2-methyl-5-nitro-1H-imidazole
696-23-1

2-methyl-5-nitro-1H-imidazole

tinidazole
19387-91-8

tinidazole

Conditions
ConditionsYield
Stage #1: 2,2'-thiobis-ethanol; 2-methyl-5-nitro-1H-imidazole With aluminum (III) chloride In toluene at 45 - 95℃; for 2.5h; Large scale;
Stage #2: With sodium molybdate; dihydrogen peroxide In toluene at 45 - 50℃; for 1h; Large scale;		66.1%
copper(II) choride dihydrate

copper(II) choride dihydrate

tinidazole
19387-91-8

tinidazole

[Cu(tinidazole)2Cl2]

[Cu(tinidazole)2Cl2]

Conditions
ConditionsYield
In ethanol for 4h; Time; Reflux;98%
In methanol at 60℃; for 6h;72%
tinidazole
19387-91-8

tinidazole

1-<2-(ethylsulphonyl)ethyl>-2-methyl-4-nitro-1H-imidazole
25459-12-5

1-<2-(ethylsulphonyl)ethyl>-2-methyl-4-nitro-1H-imidazole

Conditions
ConditionsYield
With potassium fluoride on basic alumina In 2-ethoxy-ethanol at 120℃; for 0.25h;94%
With sodium hydrogencarbonate In water for 5h; Heating; ethanol; carbonate, hydroxide, alkoxide;91%
potassium tetrachloroplatinate(II)
10025-99-7

potassium tetrachloroplatinate(II)

tinidazole
19387-91-8

tinidazole

(NO2CCHNC(CH3)N(CH2CH2S(O)2C2H5))2PtCl2
84431-12-9

(NO2CCHNC(CH3)N(CH2CH2S(O)2C2H5))2PtCl2

Conditions
ConditionsYield
In water solid ligand added to aq. soln. of K2(PtCl4), stirred at 50 °C for 1 h; ppt. filtered, washed with EtOH/Et2O, Et2O, dried in vac.; elem. anal.;88%
tinidazole
19387-91-8

tinidazole

1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazolium chloride

1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazolium chloride

Conditions
ConditionsYield
With hydrogenchloride In methanol88%
3-methoxy-4-hydroxybenzoic acid
121-34-6

3-methoxy-4-hydroxybenzoic acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C8H8O4

C8H13N3O4S*C8H8O4

Conditions
ConditionsYield
In water at 60℃; for 24h;87%
In water for 1.66667h;
nickel(II) nitrate hexahydrate

nickel(II) nitrate hexahydrate

tinidazole
19387-91-8

tinidazole

[Ni(tinidazole)2(NO3)2]

[Ni(tinidazole)2(NO3)2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;86%
tinidazole
19387-91-8

tinidazole

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn(tinidazole)2Cl2]

[Zn(tinidazole)2Cl2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;85%
zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

tinidazole
19387-91-8

tinidazole

[Zn(tinidazole)2(NO3)2]

[Zn(tinidazole)2(NO3)2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;83%
tinidazole
19387-91-8

tinidazole

zinc dibromide

zinc dibromide

[Zn(tinidazole)2Cl2]

[Zn(tinidazole)2Cl2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;82%
copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

tinidazole
19387-91-8

tinidazole

[Cu(tinidazole)2(NO3)2]

[Cu(tinidazole)2(NO3)2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;81%
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

tinidazole
19387-91-8

tinidazole

[Co(tinidazole)2(NO3)2]

[Co(tinidazole)2(NO3)2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;72%
nickel(II) bromide trihydrate

nickel(II) bromide trihydrate

tinidazole
19387-91-8

tinidazole

[Ni(tinidazole)2Br2]

[Ni(tinidazole)2Br2]

Conditions
ConditionsYield
In ethanol for 4h; Reflux;71%
copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

tinidazole
19387-91-8

tinidazole

[Cu2(OAc)4(1-(2-ethyl-sulfonylethyl)-2-methyl-5-nitroimidazole)2]
1270038-76-0

[Cu2(OAc)4(1-(2-ethyl-sulfonylethyl)-2-methyl-5-nitroimidazole)2]

Conditions
ConditionsYield
In methanol at 50℃; for 8h;70%
copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

tinidazole
19387-91-8

tinidazole

[Cu(tinidazole)(μ-AcO)2]2·H2O

[Cu(tinidazole)(μ-AcO)2]2·H2O

Conditions
ConditionsYield
In ethanol for 4h; Reflux;67%
copper(II) choride dihydrate

copper(II) choride dihydrate

tinidazole
19387-91-8

tinidazole

[Cu(tinidazole)2(μ-Cl)Cl]2

[Cu(tinidazole)2(μ-Cl)Cl]2

Conditions
ConditionsYield
In ethanol for 4h; Reflux;55%
tinidazole
19387-91-8

tinidazole

C8H15N3O2S
147597-72-6

C8H15N3O2S

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic acid In ethanol at 20℃; for 0.166667h;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C7H8O3S

C8H13N3O4S*C7H8O3S

Conditions
ConditionsYield
In water
In water for 1.66667h;
oxalic acid
144-62-7

oxalic acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C2H2O4

C8H13N3O4S*C2H2O4

Conditions
ConditionsYield
In water for 1.66667h;
tinidazole
19387-91-8

tinidazole

benzoic acid
65-85-0

benzoic acid

C8H13N3O4S*C7H6O2

C8H13N3O4S*C7H6O2

Conditions
ConditionsYield
In water for 1.66667h;
tinidazole
19387-91-8

tinidazole

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

C8H13N3O4S*C7H6O3

C8H13N3O4S*C7H6O3

Conditions
ConditionsYield
In water for 1.66667h;
3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C7H6O4

C8H13N3O4S*C7H6O4

Conditions
ConditionsYield
In water for 1.66667h;
3,4,5-trihydroxybenzoic acid
149-91-7

3,4,5-trihydroxybenzoic acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C7H6O5

C8H13N3O4S*C7H6O5

Conditions
ConditionsYield
In water for 1.66667h;
tinidazole
19387-91-8

tinidazole

Eudesmic acid
118-41-2

Eudesmic acid

C8H13N3O4S*C10H12O5

C8H13N3O4S*C10H12O5

Conditions
ConditionsYield
In water for 1.66667h;
6-Pentadecylsalicylic Acid
16611-84-0

6-Pentadecylsalicylic Acid

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C22H36O3

C8H13N3O4S*C22H36O3

Conditions
ConditionsYield
In water for 1.66667h;
3,4,5-trihydroxybenzoic acid monohydrate
5995-86-8

3,4,5-trihydroxybenzoic acid monohydrate

tinidazole
19387-91-8

tinidazole

C8H13N3O4S*C7H6O5

C8H13N3O4S*C7H6O5

Conditions
ConditionsYield
In water at 60℃; for 1h;
Propyl gallate
121-79-9

Propyl gallate

tinidazole
19387-91-8

tinidazole

tinidazole propyl gallate

tinidazole propyl gallate

Conditions
ConditionsYield
In water at 60℃; for 1h;

Tinidazole Chemical Properties

Molecular Formula: C8H13N3O4S
Molecular Weight: 247.2715 g/mol
EINECS: 243-014-4
Density: 1.43 g/cm3
Flash Point: 273.4 °C
Melting Point: 125°C to 128 °C
Boiling Point: 528.4 °C at 760 mmHg
Index of Refraction: 1.599
Surface Tension: 57.1 dyne/cm
Enthalpy of Vaporization: 77.31 kJ/mol
Boiling Point: 528.4 °C at 760 mmHg
Vapour Pressure: 1E-10 mmHg at 25 °C 
Appearance: almost white or pale yellow, crystalline powder
Solubility: insoluble in water, soluble in acetone and in methylene chloride, sparingly soluble in methanol
Synonyms: Tinidazole ; 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol ; 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol ; 1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole ; bioshik ; ethyl(2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
IUPAC Name of Tinidazole (CAS NO.19387-91-8): 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride

Tinidazole Uses

Tinidazole (CAS NO.19387-91-8) can be used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis.

Tinidazole Toxicity Data With Reference

1.    

mmo-sat 50 µg/plate

     MUREAV    Mutation Research. 77 (1980),301.
2.    

mnt-mus-ipr 50 mg/kg

     AIVMBU    Archivos de Investigacion Medica. 15 (1984),311.
3.    

orl-rat LD50:2710 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
4.    

ipr-rat LD50:2720 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
5.    

scu-rat LD50:3000 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
6.    

orl-mus LD50:3200 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 21 (1978),781.
7.    

ipr-mus LD50:2730 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
8.    

scu-mus LD50:3940 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.

Tinidazole Safety Profile

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Hazard Codes:Harmful Xn
Risk Statements: 20/21/22-40 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R40:Limited evidence of a carcinogenic effect.
Safety Statements 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: NI6255000

Tinidazole Specification

 Tinidazole (CAS NO.19387-91-8), its first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, assure adequate flushing by separating the eyelids with fingers. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : If swallowed, wash out mouth with water provided person is conscious. Get medical aid immediately.

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