Product Name

  • Name

    tofenacin hydrochloride

  • EINECS
  • CAS No. 10488-36-5
  • Density g/cm3
  • Solubility
  • Melting Point 147-148℃ (ethanol ethyl ether )
  • Formula C17H21 N O . Cl H
  • Boiling Point 353.3°Cat760mmHg
  • Molecular Weight 291.85
  • Flash Point 151.8°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. Used as an antidepressant.
  • Risk Codes
  • Molecular Structure Molecular Structure of 10488-36-5 (tofenacin hydrochloride)
  • Hazard Symbols
  • Synonyms Ethanamine,N-methyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride (9CI); Ethylamine,N-methyl-2-[(o-methyl-a-phenylbenzyl)oxy]-, hydrochloride (7CI,8CI); BS 7331; Elamol; NSC 113809;NSC 169432; Tofacine; Tofenacin hydrochloride; Tofenacine hydrochloride
  • PSA 21.26000
  • LogP 4.51330

Tofenacine hydrochloride Chemical Properties

IUPAC   Name: N-Methyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine hydrochloride   
Molecular Formula: C17H21NO•ClH
Molecular Weight: 291.85
EINECS: 234-011-9
Freely Rotating Bonds: 6
Polar Surface Area: 9.23 Å2
Flash Point: 151.8 °C
Enthalpy of Vaporization: 59.83 kJ/mol
Boiling Point: 353.3 °C at 760 mmHg
Vapour Pressure: 3.61E-05 mmHg at 25°C 
The Cas Register Number of  Tofenacine hydrochloride is 10488-36-5. The chemical synonyms of  Tofenacine hydrochloride (CAS NO.10488-36-5) are [2-(Phenyl-o-tolylmethoxy)ethyl]methylamine hydrochloride ; ethanamine, N-methyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride  ; N-Methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanaminium chloride .The molecular structure of  Tofenacine hydrochloride (CAS NO.10488-36-5) is.

Tofenacine hydrochloride Uses

  Tofenacine hydrochloride (CAS NO.10488-36-5) is used in organic synthesis .

Tofenacine hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:400 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,375.
2.    

ipr-rat LD50:72 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 177 (1969),28.
3.    

ivn-rat LD50:15 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,375.
4.    

orl-mus LD50:182 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 177 (1969),28.
5.    

ipr-mus LD50:55 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 177 (1969),28.
6.    

scu-mus LD50:82 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 177 (1969),28.
7.    

ivn-mus LD50:32 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,375.
8.    

orl-dog LD50:90 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,375.
9.    

scu-gpg LD50:92 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 177 (1969),28.

Tofenacine hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. Used as an antidepressant.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3

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