TOLAZAMIDE

IUPAC Name: 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
Molecular Formula: C₁₄H₂₁N₃O₃S
Molecular Weight: 311.399840 g/mol
EINECS: 214-588-3 
Density: 1.29 g/cm³ 
Melting Point: 170-173 °C
Index of Refraction: 1.596
Molar Refractivity: 81.86 cm³
Molar Volume: 240.5 cm³
Polarizability: 32.45×10^-24cm³
Surface Tension: 56.8 dyne/cm
Mol File: 1156-19-0.mol
Appearance: white to off-white crystalline powder
Water Solubility: 65.4 mg/L at 30 °C
Vapor Pressure: 1.07E-09 mmHg at 25 °C
Henry's Law Constant: 1.36E-12 atm-m³/mole at 25 °C
Atmospheric OH Rate Constant: 3.02E-11 cm³/molecule-sec at 25 °C
H-Bond Donor: 2
H-Bond Acceptor: 4
Rotatable Bond Count: 3
Tautomer Count: 3
MonoIsotopic Mass: 311.130362
Topological Polar Surface Area: 78.5
Heavy Atom Count: 21
Complexity: 431
Synonyms of Tolazamide (CAS NO.1156-19-0):
 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea ; 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea ;
4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide ; Tolanase ; Tolazamida ; Tolazamida ; Tolazamidum ; Tolazamidum  

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-51 ,1978. .

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Hazard Codes:  Xn
Risk Statements: 22 
R22: Harmful if swallowed
Safety Statements: 36 
S36: Wear suitable protective clothing
WGK Germany: 3
RTECS: YT4400000
 

 Tolazamide (CAS NO.1156-19-0) is odorless or with a slight odor. It may be sensitive to exposure to air for a long time. Tolazamide (CAS NO.1156-19-0)  is an amide. Amides/imides react with azo and diazo compounds to produce toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P₂O₅ or SOCl₂ generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Tolazamide (CAS NO.1156-19-0) is incompatible with acids.The flash point data for Tolazamide (CAS NO.1156-19-0) are not available; however, it is probably combustible.