Product Name

  • Name

    Tolmetin sodium

  • EINECS 252-687-3
  • CAS No. 35711-34-3
  • Article Data4
  • CAS DataBase
  • Density 1.18g/cm3
  • Solubility
  • Melting Point 155-157oC (DECOMPOSES)
  • Formula C15H15 N O3 . Na
  • Boiling Point 483.2 °C at 760 mmHg
  • Molecular Weight 279.271
  • Flash Point 246 °C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Na2O.
  • Risk Codes
  • Molecular Structure Molecular Structure of 35711-34-3 (Tolmetin sodium)
  • Hazard Symbols
  • Synonyms 1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (9CI); Sodium1-methyl-5-p-toluoylpyrrole-2-acetate; Sodium tolmetin; Tolectin; Tolmetinsodium; Tolmetin sodium salt
  • PSA 62.13000
  • LogP 0.85690

Tolmetin sodium Chemical Properties

Empirical Formula of Tolmetin sodium (CAS NO.35711-34-3): C15H14NNaO3
Molecular Weight: 279.2663 
EINECS: 252-687-3
Flash Point: 246 °C
Enthalpy of Vaporization: 78.81 kJ/mol
Boiling Point: 483.2 °C at 760 mmHg
Vapour Pressure: 3.79E-10 mmHg at 25 °C
Structure of Tolmetin sodium (CAS NO.35711-34-3):
                  
H-Bond Donor: 0
H-Bond Acceptor: 3 
IUPAC Name of Tolmetin sodium (CAS NO.35711-34-3): Sodium 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].[Na+]
InChI: InChI=1S/C15H15NO3.Na/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;/h3-8H,9H2,1-2H3,(H,17,18);/q;+1/p-1
InChIKey: QGUALMNFRILWRA-UHFFFAOYSA-M

Tolmetin sodium Uses

 Tolmetin sodium (CAS NO.35711-34-3) has been used as an antipyretic analgesic.

Tolmetin sodium Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 2520mg/kg/8W- (2520mg/kg) BLOOD: THROMBOCYTOPENIA Arthritis and Rheumatism. Vol. 25, Pg. 1144, 1982.
dog LD50 oral > 800mg/kg (800mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
hamster LD50 oral 1584mg/kg (1584mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
human TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
VASCULAR: SHOCK		 JAMA, Journal of the American Medical Association. Vol. 240, Pg. 246, 1978.
man TDLo oral 538mg/kg/61D- (538mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1263, 1980.
mouse LD50 intraperitoneal 690mg/kg (690mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse LD50 intravenous > 622mg/kg (622mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse LD50 oral 899mg/kg (899mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
mouse LD50 subcutaneous 670mg/kg (670mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 intraperitoneal 770mg/kg (770mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 intravenous > 724mg/kg (724mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 oral 914mg/kg (914mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
rat LD50 subcutaneous 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
women TDLo oral 8mg/kg (8mg/kg) SPINAL CORD: MENINGEAL CHANGES
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
LIVER: LIVER FUNCTION TESTS IMPAIRED		 JAMA, Journal of the American Medical Association. Vol. 245, Pg. 67, 1981.
 

Tolmetin sodium Safety Profile

Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Tolmetin sodium Specification

 Tolmetin sodium ,its cas register number is 35711-34-3. It also can be called Natrium-{1-methyl-5-[(4-methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetat ; 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (1:1) ; Tolectin and Sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate .

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