Tricaine methanesulfonate supplier

Name
Tricaine methanesulfonate
EINECS 212-956-8
CAS No. 886-86-2
Density 1.3799 (rough estimate)
Solubility 50 mg/mL, clear, colorless in water
Melting Point 146-149 °C(lit.)
Formula C₉H₁₁NO₂^.CH₄O₃S
Boiling Point 294.7 °C at 760 mmHg
Molecular Weight 261.299
Flash Point 151.2 °C
Transport Information
Appearance white to off-white fine powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Amino benzoic acid ethyl ester methanesulfonate;Ethyl 3-aminobenzoate methanesulfonate;(3-ethoxycarbonylphenyl)azanium; methanesulfonate;MS-222;Tricaine;Benzoic acid, 3-amino-, ethyl ester;Benzoic acid, m-amino-, ethyl ester, methanesulfonate (8CI);Methanesulfonic acid, compd. with ethyl m-aminobenzoate (1:1);MS 222;Metacaine;m-Aminobenzoic acid, ethyl ester;ethyl 3-aminobenzoate; methanesulfonic acid;Benzoic acid, m-amino-, ethyl ester, methanesulfonate;Finquel;TS-222;3-Aminobenzoic acid, ethyl ester, methanesulfonate;
PSA 115.07000
LogP 2.61150

Synthetic route

: 886-86-2
Finquel

: cucurbit[7]uril

: C42H42N28O14*C9H11NO2*CH4O3S

Conditions

Conditions	Yield
In aq. buffer pH=7.2 - 7.3;

Tricaine methanesulfonate Consensus Reports

Reported in EPA TSCA Inventory.

Tricaine methanesulfonate Specification

The Tricaine mesylate, with the CAS registry number 886-86-2 and EINECS registry number 212-956-8, has the systematic name of 3-(ethoxycarbonyl)anilinium methanesulfonate. It is also known as TMS, and the molecular formula of this chemical is C₁₀H₁₅NO₅S. What's more, it should be stored at 2-8°C.

The Tricaine mesylate is a kind of white to off-white fine powder used for anesthesia, sedation, or euthanasia of fishes. And it is the only anesthetic licensed in the United States for fin fish that is intended for human consumption. It is a muscle relaxant that operates by preventing action potentialse. What's more, it is easily soluble in water (both fresh and salt), but it drastically decreases the pH of water, increasing the acidity, which may be toxic for fish.

The physical properties of Tricaine mesylate are as following: (1)ACD/LogP: 1.54; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.54; (4)ACD/LogD (pH 7.4): 1.54; (5)ACD/BCF (pH 5.5): 8.7; (6)ACD/BCF (pH 7.4): 8.79; (7)ACD/KOC (pH 5.5): 163.28; (8)ACD/KOC (pH 7.4): 164.87; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 26.3 Å²; (13)Flash Point: 151.2 °C; (14)Enthalpy of Vaporization: 53.44 kJ/mol; (15)Boiling Point: 294.7 °C at 760 mmHg; (16)Vapour Pressure: 0.0016 mmHg at 25°C.

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCC)c1cc(ccc1)[NH3+].[O-]S(=O)(=O)C
(2)InChI: InChI=1/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
(3)InChIKey: FQZJYWMRQDKBQN-UHFFFAOYAO

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	intraperitoneal	250mg/kg (250mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	Pharmacologist. Vol. 16, Pg. 252, 1974.
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03233,

Product Name

Tricaine methanesulfonate

Synthetic route

Tricaine methanesulfonate Consensus Reports

Tricaine methanesulfonate Specification

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