• Name

  Triethyl acetyl citrate

• EINECS 201-066-5
• CAS No. 77-89-4
• Article Data6
• CAS DataBase
• Density 1.163 g/cm³
• Solubility
• Melting Point -42 °C
• Formula C₁₄H₂₂O₈
• Boiling Point 327.2 °C at 760 mmHg
• Molecular Weight 318.324
• Flash Point 136.9 °C
• Transport Information
• Appearance colorless or light yellow liquid
• Safety 23-24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1,2,3-Propanetricarboxylicacid, 2-(acetyloxy)-, triethyl ester (9CI);Citric acid, triethyl ester,acetate (6CI,7CI,8CI);ATEC;Acetyl triethyl citrate;Citroflex A 2;CitrofolAII;Morflex ATEC;NSC 3887;Triethyl 2-acetoxy-1,2,3-propanetricarboxylate;Triethyl acetylcitrate;
• PSA 105.20000
• LogP 0.75780

Synthetic route

77-93-0

citric acid triethyl ester

108-24-7

acetic anhydride

77-89-4

triethyl O-acetylcitrate

Conditions

Conditions	Yield
With 4-(dimethylamino)pyridine hydrochloride at 110℃; for 8h;	90%
sulfuric acid at 80℃; for 3h;	88%
With H-type zeolite catalyst at 60 - 120℃; under 760.051 Torr; for 2.83333h; Reagent/catalyst; Sealed tube; Inert atmosphere;
unter kontinuierlicher Entfernung der entstehenden Essigsaeure;

77-93-0

citric acid triethyl ester

75-36-5

acetyl chloride

77-89-4

triethyl O-acetylcitrate

77-89-4

triethyl O-acetylcitrate

5349-99-5

Diethyl-3-(ethoxycarbonyl)pent-2-endioat

Conditions

Conditions	Yield
at 275℃; for 1.5h;	89%
at 270℃; under 760.051 Torr; for 0.4h;	74%
at 250 - 280℃;

77-89-4

triethyl O-acetylcitrate

499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions

Conditions	Yield
at 250 - 280℃; ueberdestilliert die Essigsaeure, dann verseift man mit konz.Salzsaeure und destilliert diese unter vermindertem Druck ab;

77-89-4

triethyl O-acetylcitrate

14533-64-3

2,6-dihydroxy-isonicotinic acid amide

Conditions

Conditions	Yield
With ammonium hydroxide

77-89-4

triethyl O-acetylcitrate

A

64-19-7

acetic acid

B

aconitic acid triethyl ester

aconitic acid triethyl ester

Conditions

Conditions	Yield
at 250 - 280℃;

77-89-4

triethyl O-acetylcitrate

ammonium hydroxide

citrazinamide

citrazinamide

77-89-4

triethyl O-acetylcitrate

101967-99-1

Diethyl-2-oxo-2H-pyran-4,5-dicarboxylat

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 89 percent / 1.5 h / 275 °C 2: 45 percent / TiCl4, 4-Methylmorpholine / tetrahydrofuran; CCl4 / 20 h / Ambient temperature 3: HCOOH / 1 h / 95 °C View Scheme
Multi-step reaction with 3 steps 1.1: 0.4 h / 270 °C / 760.05 Torr 2.1: titanium tetrachloride / tetrachloromethane; tetrahydrofuran / 0.5 h / 0 °C 2.2: 20 h / 0 - 20 °C 3.1: formic acid / 1 h / 100 °C View Scheme

77-89-4

triethyl O-acetylcitrate

129256-95-7

Diethyl-3-(ethoxycarbonyl)-4-(ethoxymethylen)pent-2-endioat

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89 percent / 1.5 h / 275 °C 2: 45 percent / TiCl4, 4-Methylmorpholine / tetrahydrofuran; CCl4 / 20 h / Ambient temperature View Scheme

107-10-8

propylamine

77-89-4

triethyl O-acetylcitrate

A

5331-48-6

n-propylacetamide

B

1242516-61-5

(Z)-3-acetyl-5-oxo-N-propylhex-2-enamide

C

1242516-60-4

(Z)-3-((propylcarbamoyl)-methylene)-4-oxopentanoic acid

D

1242516-62-6

(Z)-3,4-bis(propylcarbamoyl)but-3-enoic acid

E

1,2,3-tris(propylcarbamoyl)propyl-2-yl acetate

Conditions

Conditions	Yield
In methanol at 20℃;

...Expand

77-89-4

triethyl O-acetylcitrate

109-73-9

N-butylamine

A

1119-49-9

N-butylacetamide

B

1242516-63-7

1,2,3-tris(butylcarbamoyl)propan-2yl acetate

Conditions

Conditions	Yield
In methanol at 20℃;

...Expand

67-56-1

methanol

77-89-4

triethyl O-acetylcitrate

75-64-9

tert-butylamine

A

1587-20-8

trimethyl citrate

B

77-93-0

citric acid triethyl ester

C

1242516-65-9

dimethyl 3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioate

D

1242516-64-8

3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioic acid

Conditions

Conditions	Yield
at 20℃;

...Expand

77-89-4

triethyl O-acetylcitrate

triethyl 4-ethoxybuta-1,3-diene-1,2,3-tricarboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 0.4 h / 270 °C / 760.05 Torr 2.1: titanium tetrachloride / tetrachloromethane; tetrahydrofuran / 0.5 h / 0 °C 2.2: 20 h / 0 - 20 °C View Scheme

Triethyl acetyl citrate Chemical Properties

Triethyl acetyl citrate Toxicity Data With Reference

Triethyl acetyl citrate Consensus Reports

Triethyl acetyl citrate Safety Profile

Triethyl acetyl citrate Specification