Triisopropanolamine supplier

Name
Triisopropanolamine
EINECS 204-528-4
CAS No. 122-20-3
Article Data10
CAS DataBase
Density 1.0 g/cm³
Solubility Soluble in water, ethanol, ethyl ether
Melting Point 48-52 °C(lit.)
Formula C₉H₂₁NO₃
Boiling Point 296.4 °C at 760 mmHg
Molecular Weight 191.271
Flash Point 167 °C
Transport Information UN 3259 8/PG 2
Appearance white to slightly yellow powder
Safety 26-61
Risk Codes 36-52/53
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Propanol,1,1',1''-nitrilotri- (6CI,8CI);1,1',1''-Nitrilotri-2-propanol;1,1',1''-Nitrilotris(2-propanol);CBA (aminoalcohol);NSC 4010;TIPA;Tri-2-propanolamine;Tri-iso-propanolamine;Tris(2-hydroxy-1-propyl)amine;Tris(2-hydroxypropyl)amine;Tris(2-propanol)amine;Triisopropanolamine;
PSA 63.93000
LogP -0.56920

Synthetic route

: 75-56-9, 16033-71-9
methyloxirane

: 122-20-3
triisopropanolamine

Conditions

Conditions	Yield
With ammonia; water at 100℃; under 44130.5 - 58840.6 Torr;
With ammonia; water
With ammonia at 125℃;
With ammonia; water

: 64235-17-2, 64235-28-5, 71229-51-1
1,3,7,10-tetramethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

A: 122-20-3
triisopropanolamine

B: 2445-53-6
methylsilanetriol

Conditions

Conditions	Yield
With disodium hydrogenphosphate; potassium dihydrogenphosphate at 50℃; Rate constant; Mechanism; hydrolysis in neutral medium;

: 7780-04-3
1-amino-2-propanol hydrochloride

: 122-20-3
triisopropanolamine

Conditions

Conditions	Yield
With sodium methylate In methanol

: 75-56-9, 16033-71-9
methyloxirane

: 122-20-3
triisopropanolamine

Conditions

Conditions	Yield
With ammonia; water at 100℃; under 44130.5 - 58840.6 Torr;
With ammonia; water
With ammonia at 125℃;
With ammonia; water

: 64235-17-2, 64235-28-5, 71229-51-1
1,3,7,10-tetramethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

A: 122-20-3
triisopropanolamine

B: 2445-53-6
methylsilanetriol

Conditions

Conditions	Yield
With disodium hydrogenphosphate; potassium dihydrogenphosphate at 50℃; Rate constant; Mechanism; hydrolysis in neutral medium;

: 7780-04-3
1-amino-2-propanol hydrochloride

: 122-20-3
triisopropanolamine

Conditions

Conditions	Yield
With sodium methylate In methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 122-20-3
triisopropanolamine

B: 78-96-6, 1674-56-2
3-amino-2-propanol

C: 110-97-4
diisopropanolamine

Conditions

Conditions	Yield
With ammonia at 60℃; Temperature; Reagent/catalyst;

...Expand

: 122-20-3
triisopropanolamine

: 75-79-6
Methyltrichlorosilane

: 1,3,7,10-Tetramethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane; hydrochloride

Conditions

Conditions	Yield
In dichloromethane	100%

: 122-20-3
triisopropanolamine

: 5089-70-3
(3-chloropropyl)triethoxysilane

: 1-(3-chloropropyl)-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane

Conditions

Conditions	Yield
With potassium hydroxide at 90℃; under 100 - 350 Torr; for 4h;	98.2%

: 122-20-3
triisopropanolamine

: 681-97-0
triethoxy-(3,3,3-trifluoro-propyl)-silane

: 63453-67-8
3,7,10-trimethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

Conditions

Conditions	Yield
With sodium ethanolate In ethanol Heating;	98%

: 122-20-3
triisopropanolamine

: 1558-25-4
(chloromethyl)trichlorosilane

: 57078-94-1, 64235-15-0, 64235-26-3
1-chloromethyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

Conditions

Conditions	Yield
In chloroform	97%

: 122-20-3
triisopropanolamine

: 79-43-6
dichloro-acetic acid

: triisopropanolamine dichloroacetate

Conditions

Conditions	Yield
at 20℃; for 12h; Cooling with ice;	96%
In methanol at 20℃; for 24h;	90%

: 122-20-3
triisopropanolamine

: 7795-95-1
octane-1-sulfonyl chloride

: 40630-63-5
octanesulfonyl fluoride

Conditions

Conditions	Yield
With potassium fluoride In water	95%

: 122-20-3
triisopropanolamine

: 30674-80-7
2-Isocyanatoethyl methacrylate

: (8-(2-(((2-(methacryloyloxy)ethyl)carbamoyl)oxy)propyl)-6,10-dimethyl-4,12-dioxo-5,11-dioxa-3,8,13-triazapentadecane-1,15-diyl bis(2-methylacrylate))

Conditions

Conditions	Yield
With dibutyltin dilaurate In ethyl acetate at 20 - 25℃; for 24h;	95%

: 122-20-3
triisopropanolamine

: 16068-37-4
1,2-bis(triethoxysilyl)ethane

: 1,2-bis(3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-yl)ethane

Conditions

Conditions	Yield
With potassium hydroxide In toluene at 100℃; under 100 - 760 Torr; for 4h;	94%
With potassium hydroxide at 220℃;	38%

: 122-20-3
triisopropanolamine

: 17980-47-1
isobutyltriethoxysilane

: 1-isobutyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane

Conditions

Conditions	Yield
With potassium hydroxide at 100℃; under 100 - 400 Torr; for 4h;	93.7%

: 122-20-3
triisopropanolamine

: 115-21-9
ethyltrichlorosilane

: 1-Ethyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

Conditions

Conditions	Yield
In chloroform	93%

: 122-20-3
triisopropanolamine

: 5929-71-5
allyltriacetoxysilane

: 93556-58-2
1-allyl-3,7,10-trimethylsilatrane

Conditions

Conditions	Yield
In chloroform at 0℃; for 1h;	92%

: 122-20-3
triisopropanolamine

: 35141-30-1
(3-trimethoxysilylpropyl)diethylenetriamine

: N-(2-amino-ethyl)-N'-[3-(3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undec-1-yl)-propyl]-ethane-1,2-diamine

Conditions

Conditions	Yield
potassium hydroxide; sodium methylate In benzene Heating;	92%

: 122-20-3
triisopropanolamine

: C7H15NO3

Conditions

Conditions	Yield
With manganese(IV) oxide; oxygen In chlorobenzene at 100℃; under 4500.45 Torr; for 4h; Autoclave; Green chemistry;	92%

: 122-20-3
triisopropanolamine

: 203456-00-2
copper(II) succinate

: [CuII(tris(2-hydroxypropyl)amine)(succinato)]

Conditions

Conditions	Yield
In water for 3h; Reflux;	92%

: 122-20-3
triisopropanolamine

: nickel(II)cinnamate

: [NiII(tris(2-hydroxypropyl)amine)2](cinnamate)2

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	91%

: 122-20-3
triisopropanolamine

: 58901-12-5
N,N,N-tris(2-hydroxypropyl)amine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 85 - 90℃; for 4h; Temperature; Inert atmosphere;	90.6%
With hydrogenchloride In water at 40℃; pH=2;

: 122-20-3
triisopropanolamine

: 23843-64-3
1-[3-(trimethoxysilyl)]propylurea

: N-[3-(3,7,10-trimethylsilatranyl)propyl]urea

Conditions

Conditions	Yield
With potassium hydroxide In toluene for 3h; Heating;	90%

: 122-20-3
triisopropanolamine

: zinc(II) cinnamate

: [Zn(tris(2-hydroxypropyl)amine)2](cinnamate)2

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	90%

: 122-20-3
triisopropanolamine

: 69-72-7
salicylic acid

: tris(2-hydroxypropyl)ammonium salicylate

Conditions

Conditions	Yield
In methanol for 2h; Reflux;	90%

: 122-20-3
triisopropanolamine

: 105923-28-2
2-((3-(triethoxysilyl)propyl)thio)benzo[d]thiazole

: S-[3-(3,7,10-trimethylsilatranyl)propyl]mercaptobenzothiazole

Conditions

Conditions	Yield
With potassium hydroxide In toluene Inert atmosphere; Schlenk technique; Dean-Stark; Reflux;	89%

: 122-20-3
triisopropanolamine

: 78-10-4
tetraethoxy orthosilicate

: 18051-99-5
1-ethoxy-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane

Conditions

Conditions	Yield
With potassium hydroxide at 85 - 120℃; under 100 - 200 Torr; for 3h;	88.2%

: 122-20-3
triisopropanolamine

: 3388-04-3
trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane

: 2-[(3,4-epoxycyclohexyl)ethyl]-3,7,10-trimethylsilatrane

Conditions

Conditions	Yield
With potassium hydroxide In toluene for 3h; Heating;	88%

: 122-20-3
triisopropanolamine

: N-(3-(trimethoxysilyl)propyl)isonicotinamide

: N-(3-(3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-yl)propyl)isonicotinamide

Conditions

Conditions	Yield
With potassium hydroxide In toluene at 110 - 115℃; for 5h;	88%

: 122-20-3
triisopropanolamine

: 78-08-0
Triethoxyvinylsilane

: 1-vinyl-3,7,10-trimethylsilatrane

Conditions

Conditions	Yield
With sodium hydroxide at 30 - 60℃; for 4h;	87%

: 122-20-3
triisopropanolamine

: 59-67-6
nicotinic acid

: tris(2-hydroxypropyl)ammonium nicotinate

Conditions

Conditions	Yield
In methanol for 2h; Reflux;	87%

: 122-20-3
triisopropanolamine

: 7646-79-9
cobalt(II) chloride

: [CoII2(tris(2-hydroxypropyl)amine)2Cl2]Cl2

Conditions

Conditions	Yield
In ethanol; water for 3h; Reflux;	86%

: 122-20-3
triisopropanolamine

: 2551-83-9
allyltrimethoxysilane

: 1-allyl-3,7,10-trimethylsilatrane

Conditions

Conditions	Yield
With sodium methylate	85%

: 122-20-3
triisopropanolamine

: 2530-83-8
3-glycidoxypropyltrimethoxysilane

: 1026852-18-5
3,7,10-trimethyl-1-(3-(oxiran-2-ylmethoxy)propyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane

Conditions

Conditions	Yield
With titanium(IV) isopropylate In methanol; toluene for 18h; Heating;	85%

: 122-20-3
triisopropanolamine

: 26115-70-8
tris-[3-(trimethoxysilyl)propyl]isocyanurate

: tris[3-(3,7,10-trimethylsilatranyl)propyl]isocyanurate

Conditions

Conditions	Yield
With potassium hydroxide In benzene for 2h; Heating;	85%

: 122-20-3
triisopropanolamine

: 110-15-6
succinic acid

: 2C9H21NO3*C4H6O4

Conditions

Conditions	Yield
In methanol for 2h; Reflux;	85%

Triisopropanolamine Specification

The Triisopropanolamine, with the CAS registry number 122-20-3, is also known as Tris(2-hydroxy-1-propyl)amine. It belongs to the product categories of Intermediates of Dyes and Pigments; Organics. Its EINECS number is 204-528-4. This chemical's molecular formula is C₉H₂₁NO₃ and molecular weight is 191.27. What's more, its systematic name is 1,1',1''-nitrilotripropan-2-ol. Its classification code is Skin / Eye Irritant. It is used as a pharmaceutical raw materials and a photographic developer solvent. It is also used as a cosmetics emulsifier. It can be prepared by epoxy propane and ammonia.

Physical properties of Triisopropanolamine are: (1)ACD/LogP: -0.07; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.46; (4)ACD/LogD (pH 7.4): -0.75; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 4.55; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 9; (12)Polar Surface Area: 30.93 Å²; (13)Index of Refraction: 1.495; (14)Molar Refractivity: 51.94 cm³; (15)Molar Volume: 177.9 cm³; (16)Polarizability: 20.59×10^-24cm³; (17)Surface Tension: 43.9 dyne/cm; (18)Density: 1.074 g/cm³; (19)Flash Point: 167 °C; (20)Enthalpy of Vaporization: 62.2 kJ/mol; (21)Boiling Point: 296.4 °C at 760 mmHg; (22)Vapour Pressure: 0.000148 mmHg at 25°C.

Uses of Triisopropanolamine: it can be used to produce 1-allyl-3,7,10-trimethylsilatrane at the temperature of 80 - 85 °C. It will need reagent NaOH with the reaction time of 12 hours. The yield is about 63%.

2-Propanol,1,1',1''-nitrilotris- can be used to produce 1-allyl-3,7,10-trimethylsilatrane at the temperature of 80 - 85 °C

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes. It is harmful to aquatic organisms as it may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You must avoid releasing it to the environment just refering to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(CN(CC(O)C)CC(O)C)C
(2)Std. InChI: InChI=1S/C9H21NO3/c1-7(11)4-10(5-8(2)12)6-9(3)13/h7-9,11-13H,4-6H2,1-3H3
(3)Std. InChIKey: SLINHMUFWFWBMU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1580mg/kg (1580mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
mammal (species unspecified)	LD50	skin	> 1gm/kg (1000mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(7), Pg. 46, 1986.
mouse	LD50	oral	2520mg/kg (2520mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.
rabbit	LD50	oral	11gm/kg (11000mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.
rabbit	LDLo	skin	10mL/kg (10mL/kg)		Union Carbide Data Sheet. Vol. 4/21/1967,
rat	LD50	oral	4730mg/kg (4730mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(7), Pg. 46, 1986.
rat	LD50	oral	4730mg/kg (4730mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(7), Pg. 46, 1986.

Product Name

Triisopropanolamine

Synthetic route

Triisopropanolamine Specification

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