Product Name

  • Name

    TRIMETHYLCOLCHICINIC ACID

  • EINECS
  • CAS No. 3482-37-9
  • Article Data15
  • CAS DataBase
  • Density 1.32g/cm3
  • Solubility
  • Melting Point >230°C (dec.)
  • Formula C19H21 N O5
  • Boiling Point 629°Cat760mmHg
  • Molecular Weight 343.379
  • Flash Point 334.2°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
  • Risk Codes 20/21/22
  • Molecular Structure Molecular Structure of 3482-37-9 (TRIMETHYLCOLCHICINIC ACID)
  • Hazard Symbols
  • Synonyms Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-; Colchiceine,N-deacetyl- (8CI); Colchicinic acid, O,O',O''-trimethyl- (6CI,7CI);Deacetylcolchiceine; Desacetylcolchiceine; N-Deacetylcolchiceine; NSC 36796;Trimethylcolchicinic acid
  • PSA 91.01000
  • LogP 3.09150

Trimethylcolchicinic acid Chemical Properties

IUPAC Name: 7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one  
Molecular Formula: C19H21NO5
Molecular Weight: 343.41
Properties: yellow-green solid 
EINECS: 222-464-5
Density: 1.32g/cm3
Melting Point: >230°C (dec.)
Boiling Point: 629°C at 760mmHg
Flash Point: 334.2°C
Freely Rotating Bonds: 5
Polar Surface Area: 57.23 Å2
Index of Refraction: 1.628
Molar Refractivity: 92.35 cm3
Molar Volume: 260 cm3
Polarizability: 36.61× 10-24 cm3
Surface Tension: 59 dyne/cm
Enthalpy of Vaporization: 97.82 kJ/mol
Vapour Pressure: 1.09E-16 mmHg at 25°C 
Storage temperature: −20°C
The Cas Register Number of Trimethylcolchicinic acid is 3482-37-9.The chemical synonyms of Trimethylcolchicinic acid (CAS NO.3482-37-9) are Trimethylcolchicinic acid ; 7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)heptalen-9(5h)-on ; Deacetylcholchiceine ; Desacetylcholchiceine ; N-Deacetyl-colchicein ; Trimethyl-colchicinicaci ; N-Deacetylcolchiceine ; (S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one .Product categories of Trimethylcolchicinic acid (CAS NO.3482-37-9) are All inhibitors ; Inhibitors ; Alkaloids forensic and veterinary standards ; Chemical structure; Drugs of abuse ; Drugs and Metabolites ; Neat compounds drugs of abuse ; Others alphabetic ; TP - TZ  .The molecular structure of Trimethylcolchicinic acid (CAS NO.3482-37-9) is.

Trimethylcolchicinic acid Uses

 Trimethylcolchicinic acid (CAS NO.3482-37-9) is used as  an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization.

Trimethylcolchicinic acid Toxicity Data With Reference

1.    

oms-mus-par 200 mg/kg

    CANCAR    Cancer. 3 (1950),134.
2.    

spm-mus-par 200 mg/kg

    CANCAR    Cancer. 2 (1950),134.
3.    

ipr-mus LD50:200 mg/kg

    CANCAR    Cancer. 3 (1950),124.

Trimethylcolchicinic acid Safety Profile

Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GH0960000

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