Trometamol supplier | CasNO.77-86-1

Name
Tris Base
EINECS 201-064-4
CAS No. 77-86-1
Article Data35
CAS DataBase
Density 1,353 g/cm3
Solubility water: 4 M at 20 °C, clear, colorless
Melting Point 167-172 °C(lit.)
Formula C₄H₁₁NO₃
Boiling Point 219-220 °C (10 mmHg)
Molecular Weight 121.136
Flash Point 219-220°C/10mm
Transport Information
Appearance white crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Tris(hydroxymethyl)aminomrthane;Tris (hydroxymethyl) aminoethane;2-Amino-1,3-dihydroxy-2-(hydroxymethyl)propane;2-Amino-2-(hydroxymethyl)propane-1,3-diol;2-Amino-2-hydroxymethylpropan-1,3-diol;2-Amino-2-methylol-1,3-propanediol;Addex-Tham;Aminotri(hydroxymethyl)methane;Aminotrimethylolmethane;Aminotris(hydroxymethyl)methane;Methanamine,1,1,1-tris(hydroxymethyl)-;NSC 103026;NSC 6365;NSC 65434;Pehanorm;TAM(buffering agent);THAM;Talatrol;Tri Amino;Tri(hydroxymethyl)methylamine;Trigmo base;Triladyl;Trimethylolaminomethane;Tris (buffering agent);Tris Amino;Tris Amino Crystal;Tris base;Tris buffer;Tris(methylolamino)methane;[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amine;Tris Base; Tris(hydroxymethyl)-aminomethane;Trometamol;
PSA 86.71000
LogP -1.63890

Synthetic route

: {NiCl2(2-(2-pyridinyl)-4,4-bis(hydroxymethyl)-2-oxazoline)2}

A: {Ni(H2O)2(pyridine-2-carboxylic acid)2}*2H2O

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water reflux (50 h);; pptn.; filtration; washing (ethanol); drying (vac.); elem. anal.; evapn. of aq. filtrate; extraction (3 times/hot ethanol); cooling of filtrate yields 2-amino-2-hydroxymethyl-1,3-propanediol;;	A 85% B 75%

: 126-11-4
2-hydroxymethyl-2-nitro-propane-1,3-diol

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With sulfuric acid; iron at 100℃;
With water; iron; iron(II) sulfate at 30℃;
With water; iron; iron(II) sulfate at 100℃;

: 19320-52-6
Protonated tris(hydroxymethyl)aminoamethane

: 114444-46-1
C14H13NO

A: 124225-44-1
1-methyl-4-(phenylacetyl)pyridinium cation

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Rate constant;

...Expand

: 19320-52-6
Protonated tris(hydroxymethyl)aminoamethane

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water; acetonitrile at 25℃; Thermodynamic data; ΔrGm0, var. of solvent, temp.;

: N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-2-oxoethoxy}-1,3-benzenedicarboxamide

A: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

B: [3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

Conditions

Conditions	Yield
With water at 95℃; Rate constant;

5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene: 5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With mineral acid

: Sodium; 2-{[(E)-2-hydroxy-1,1-bis-hydroxymethyl-ethylimino]-methyl}-benzenesulfonate

A: 1008-72-6
sodium 2-formylbenzenesulfonate

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: C9H18NO10P(2-)*2Na(1+)

A: 108321-99-9, 150713-51-2
α,β-D-ribofuranose-5-phophate disodium salt

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
Equilibrium constant;

boc-Pro-Phe-His(Ts)-OH: boc-Pro-Phe-His(Ts)-OH

: diethylphosphoryl cyanide

A boc-Pro-Phe-His-LVA-Ile: boc-Pro-Phe-His-LVA-Ile

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid In tetrahydrofuran; methanol; dichloromethane; ethyl acetate

...Expand

: tris(hydroxymethyl)aminomethane-silicofluoric acid (2/1)

A: 7664-39-3
hydrogen fluoride

B: 7783-61-1
silicon tetrafluoride

C: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In neat (no solvent) thermogravimetric expt. (platinum crucible, heating rate of 10 K/min); heating to 200-268°C;

...Expand

: 79-06-1
2-propenamide

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 95-92-1
oxalic acid diethyl ester

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 5714-31-8
N,N'-bis[tris(hydroxymethyl)methyl]ethanediamide

Conditions

Conditions	Yield
at 140℃; for 1h;	100%
In ethylene glycol at 100 - 105℃; for 6h; Conversion of starting material;	92%

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1-(2-Hydroxy-1,1-bis-hydroxymethyl-ethyl)-3-(2-vinyloxy-ethyl)-thiourea

Conditions

Conditions	Yield
at 70℃; for 1h;	100%

: 107-21-1
ethylene glycol

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: C6H12NO5Si

Conditions

Conditions	Yield
With silica gel Heating;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 146651-71-0
N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol

Conditions

Conditions	Yield
In methanol at 20℃;	100%
In methanol; water at 20℃; for 72h;	100%
With guanidine hydrochloride In ethanol at 35 - 40℃; for 0.0833333h;	100%

: 383-63-1
ethyl trifluoroacetate,

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: N-trifluoroacetyl-tris(hydroxymethyl)aminomethane

Conditions

Conditions	Yield
In acetonitrile	100%

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-azido-2-(hydroxymethyl)propane-1,3-diol

Conditions

Conditions	Yield
With triflic azide; sodium hydrogencarbonate; copper(II) sulfate In methanol; toluene at 20℃; for 14h;	100%
With sodium azide; zinc(II) chloride; trifluorormethanesulfonic acid; triethylamine In dichloromethane; water

: C51H60O6

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: C53H65NO8

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)pivalamide

Conditions

Conditions	Yield
In methanol; water at 20℃; for 72h;	100%

: 518-44-5
dihydrofluorescein

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-hydroxy-1,1-bis-hydroxymethyl-ethyl-ammonium 2-(3,6-dihydroxy-9H-xanthen-9-yl)-benzoate salt

Conditions

Conditions	Yield
In ethanol at 20℃; for 2h;	100%

: 124-13-0
Octanal

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 944882-97-7
C20H39NO3

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	100%

: 35700-23-3
Carboprost

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: carboprost tromethamine

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	100%
In isopropyl alcohol at 20℃; for 1h;

: (R)-3-(5-chloro-2-oxo-6-(1-(pyridin-2-yl)ethoxy)benzo[d]oxazol-3(2H)-yl)propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol (R)-3-{5-chloro-2-oxo-6-[1-(pyridin-2-yl)ethoxy]-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	100%

: 3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 1h;	100%

: 3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions

Conditions	Yield
In methanol; water at 20℃; for 1h;	100%

: 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions

Conditions	Yield
In methanol; water at 80℃; for 1h;	100%

: 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 0.5h;	100%

: 3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 1h;	100%

: 3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 0.5h;	100%

: 3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 1h;	100%

: 3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%

: 3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%

: 3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%

: 3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	100%

: 3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%

: 3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	100%

: 3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	100%

: 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

Conditions

Conditions	Yield
In 1,4-dioxane; water Heating;	100%

: 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol salt

Conditions

Conditions	Yield
In ethanol; water Heating;	100%

: carboprost

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: tromethamine prostaglandin

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 12h;	100%

: 501919-59-1
2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid 2-amino-2-(hydroxymethyl)-1,3-propanediol

Conditions

Conditions	Yield
In tetrahydrofuran; ethanol at 0℃; for 1.5h; Solvent;	100%

Trometamol Specification

1. Introduction of Trometamol

The Tromethamine, with its CAS NO 77-86-1,is a kind of white Crystalline Powderthe. It has synonyms of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)- ; 2-(Hydroxymethyl)-2-amino-1,3-propanediol ; 2-Amino-2-(hydroxymethyl)-1,3-propanediol ; 2-Amino-2-methylol-1,3-propanediol ; AI3-03948 ; Addex-tham ; Aminotrimethylolmethane ; Aminotris(hydroxymethyl)methane and Apiroserum Tham. Trometamol should be stored in shady and cool warehouse.

2. Properties of Trometamol

(1) Einecs: 201-064-4 (2) Index of Refraction: 1.544 (3) Molar Refractivity: 28.68 cm3
(4) Molar Volume: 90.8 cm3 (5) Melting Point: 167-172 °C(lit.) (6) Boiling point: 357 °C at 760 mmHg
(7) Flash Point: 169.7 °C (8) Density: 1.334 g/cm3 (9) Surface Tension: 73.2 dyne/cm
(10) Enthalpy of Vaporization: 69.73 kJ/mol (11) Vapour Pressure: 1.57E-06 mmHg at 25 °C
(12) XLogP3-AA: -2.9 (13) H-Bond Donor: 4 (14) H-Bond Acceptor: 4

3. Structure descriptors of Trometamol

Canonical SMILES: C(C(CO)(CO)N)O
InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N

4. Safety information of Trometamol

Hazard Codes: Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.

5. Toxicity data of Trometamol

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	1210mg/kg (1210mg/kg)		Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LD50	intravenous	1800mg/kg (1800mg/kg)		Drugs in Japan Vol. -, Pg. 419, 1990.
rat	LD50	oral	5900mg/kg (5900mg/kg)		Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

Product Name

Tris Base

Synthetic route

Trometamol Specification

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