Product Name

  • Name

    tropacocaine hydrochloride

  • EINECS
  • CAS No. 637-23-0
  • Article Data2
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point
  • Formula C15H19 N O2 . Cl H
  • Boiling Point 339.9oC at 760 mmHg
  • Molecular Weight 281.782
  • Flash Point 122.3oC
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • Risk Codes
  • Molecular Structure Molecular Structure of 637-23-0 (tropacocaine hydrochloride)
  • Hazard Symbols
  • Synonyms 8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, benzoate (ester), hydrochloride, exo-; Tropacocaine, hydrochloride(7CI); NSC 76018; Pseudotropine benzoate hydrochloride
  • PSA 29.54000
  • LogP 3.20850

Synthetic route

benzoyl chloride
98-88-4

benzoyl chloride

pseudotropine
135-97-7

pseudotropine

Tropacocaine hydrochloride
637-23-0

Tropacocaine hydrochloride

Conditions
ConditionsYield
Stage #1: benzoyl chloride; pseudotropine With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether; ethanol
Stage #1: benzoyl chloride; pseudotropine With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2.5h;
Stage #2: With hydrogenchloride In diethyl ether; ethanol
Tropacocaine hydrochloride
637-23-0

Tropacocaine hydrochloride

Nortropacocaine
18470-33-2, 20811-95-4, 123202-90-4

Nortropacocaine

Conditions
ConditionsYield
With sodium perchlorate; water; sodium carbonate pH=10; pH-value; Electrochemical reaction; Green chemistry;81%
Tropacocaine hydrochloride
637-23-0

Tropacocaine hydrochloride

tropacocain
537-26-8

tropacocain

Conditions
ConditionsYield
With ammonia In water
With ammonia In water

Tropacaine hydrochloride Chemical Properties

IUPAC Name: (8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) benzoate hydrochloride
CAS: 637-23-0
Following is the Molecular Structure of Tropacaine hydrochloride (637-23-0):

SMILES: Cl.O=C(OC2CC1N(C)C(CC1)C2)c3ccccc3
InChI: InChI=1/C15H19NO2.ClH/c1-16-12-7-8-13(16)10-14(9-12)18-15(17)11-5-3-2-4-6-11;/h2-6,12-14H,7-10H2,1H3;1H
InChIKey: MMAGCXHWOMQWKW-UHFFFAOYAB
Std.InChI: InChI=1S/C15H19NO2.ClH/c1-16-12-7-8-13(16)10-14(9-12)18-15(17)11-5-3-2-4-6-11;/h2-6,12-14H,7-10H2,1H3;1H
Std.InChIKey: MMAGCXHWOMQWKW-UHFFFAOYSA-N
Molecular Formula: C15H19NO2.ClH
Molecular Weight: 281.7778
Boiling Point: 339.9℃ at 760mmHg
Flash Point: 122.3℃
Enthalpy of Vaporization: 58.34kJ/mol
Vapour Pressure: 8.92E-05mmHg at 25℃

Tropacaine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 465mg/kg (465mg/kg)   Research Communications in Substances Abuse. Vol. 5, Pg. 279, 1984.
mouse LDLo intraperitoneal 350mg/kg (350mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 227, 1934.
mouse LDLo intravenous 42mg/kg (42mg/kg) BEHAVIORAL: GENERAL ANESTHETIC "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936.

Tropacaine hydrochloride Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route.It's an experimental teratogen.

Tropacaine hydrochloride Specification

 Tropacaine hydrochloride (637-23-0) also can be called for Tropacocaine hydrochloride ; Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate ; Tropacaine hydrochloride ; 1-alpha-h,5-alpha-H-Tropan-3-alpha-ol,benzoate(ester),hydrochloride ; 8-Azabicyclo(3.2.1)octan-3-ol,8-methyl-, benzoate (ester),hydrochloride,ex benzoylpseudotropine hydrochloride ; O-benzoyltropine hydrochloride ; Pseudotropine benzoate hydrochloride ; Tropacocain hydrochloride .When Tropacaine hydrochloride (637-23-0) was heated,it emits toxic fumes of NOx and HCl .

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