Tubocurarine supplier | CasNO.57-95-4

Name
Tubocurarine
EINECS
CAS No. 57-95-4
Density g/cm³
Solubility
Melting Point
Formula C37H41 N2 O6
Boiling Point °Cat760mmHg
Molecular Weight 624.84
Flash Point °C
Transport Information
Appearance
Safety A deadly poison by subcutaneous, intraperitoneal, intramuscular, and intravenous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-;Tubocurarine (8CI);(+)-Tubocurarine;13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-,[13aR-(13aR*,25aS*)]-;Tubocurarin;d-Tubocurarine;
PSA 80.62000
LogP 6.59770

Tubocurarine Chemical Properties

Product Name: Tubocurarine
The MF of Tubocurarine (CAS NO.57-95-4) is C₃₇H₄₁N₂O₆.

The MW of Tubocurarine (CAS NO.57-95-4) is 609.7307.
Synonyms of Tubocurarine (CAS NO.57-95-4): (+)-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium ; 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium

Tubocurarine History

It is one of the chemicals that can be obtained from curare, itself an extract of Chondrodendron tomentosum, a plant found in South American jungles which is used as a source of arrow poison. Native Indians hunting animals with this poison were able to eat the animal's contaminated flesh without being affected by the toxin because tubocurarine cannot easily cross mucous membranes and is thus inactive orally.
Medically, first used in 1912. Introduced in anaesthesia in 1942. The correct chemical structure was only elucidated circa 1970, even though the plant had been known since the Spanish Conquest.
The word curare comes from the South American Indian name for the arrow poison: "ourare". Presumably the initial syllable was pronounced with a heavy glottal stroke. Tubocurarine is so called because the plant samples containing it were first shipped to Europe in tubes.
Today, tubocurarine has fallen into disuse in western medicine, as safer synthetic alternatives such as atracurium are available.

Tubocurarine Uses

Tubocurarine (CAS NO.57-95-4) is an antagonist of nicotinic neuromuscular acetylcholine receptors that is used to paralyse patients undergoing.

Tubocurarine Production

Tubocurarine biosynthesis involves a radical coupling of two enantiomeric tetrahydrobenzylisoquinolines, more specifically, the two enantiomers of N-methyl-coclaurine. (R) and (S)-N-methyl-coclaurine come from a Mannich-like reaction between dopamine and 4-hydroxyphenyl-acetaldehyde, facilitated by norcoclaurine synthase (NCS). Both dopamine and 4-hydroxyphenylacetyladehyde originate from L-tyrosine. The biosynthetic pathway is described in more detail in the figures. Methylation of the amine and hydroxyl substituents are facilitated by S-adenosyl methionine (SAM).

Tubocurarine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	700ug/kg (0.7mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 152, 1959.
dog	LD50	intravenous	500ug/kg (0.5mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
dog	LDLo	intramuscular	250ug/kg (0.25mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 638, 1958.
mouse	LD50	intraperitoneal	410ug/kg (0.41mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 308, 1965.
mouse	LD50	intravenous	130ug/kg (0.13mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 130, 1965.
mouse	LD50	subcutaneous	525ug/kg (0.525mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 603, 1954.
mouse	LD50	unreported	450ug/kg (0.45mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Pharmaceutical Chemistry Journal Vol. 2, Pg. 117, 1968.
rabbit	LD50	intravenous	20ug/kg (0.02mg/kg)		Rendiconti Istituto Superiore di Sanita Vol. 13, Pg. 339, 1950.
rabbit	LD50	subcutaneous	500ug/kg (0.5mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 631, 1948.
rat	LD50	intraperitoneal	220ug/kg (0.22mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 454, 1948.
rat	LDLo	intramuscular	500ug/kg (0.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 638, 1958.

Tubocurarine Safety Profile

A deadly poison by subcutaneous, intraperitoneal, intramuscular, and intravenous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits toxic fumes of NO_x.

Tubocurarine Specification

Tubocurarine chloride is an alkaloid of the benzylisoquinoline type.

Product Name

Tubocurarine