Product Name

  • Name

    Tween 60

  • EINECS -0
  • CAS No. 9005-67-8
  • Density 1.044 g/mL at 25 °C(lit.)
  • Solubility 100 g/L
  • Melting Point 45-50 °C
  • Formula Unspecified
  • Boiling Point 583.8°C at 760 mmHg
  • Molecular Weight 0
  • Flash Point >230 °F
  • Transport Information
  • Appearance
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 9005-67-8 (Tween 60)
  • Hazard Symbols
  • Synonyms Ahco DFS 100;Armotan PMS 20;Crillet31;Drewpone 60;E 435;Emerest2654;Emsorb 6906;Ethsorbox S;Glycosperse S 20;Kaopan TW-S 120;Lumisorb PSMS 20;Newcol 65;Nikkol TS 106;Nikkol TS 10V;NissanNonion ST 220;Nissan Nonion STN 201.5;Nonion ST 220;PEG sorbitan monostearate;Polisorbac 80;Poly(oxyethylene)sorbitan monostearate;Polyethylene glycol sorbitan monostearate ether;Polyoxyethylene sorbitan ether monostearate;Polyoxyethylene sorbitanmonostearic acid ester;Polysorbate 60;Propoxylated sorbitol monostearate;Rheodol TW-S 106;Rheodol TW-S 120V;Silvan T 60;Sorbital S 20;Sorbitan monostearate polyoxyethyleneether;Sorbon T 60;T 60;T-MAZ 60K;TS 10;TS 10MV;TW-S 106;Tandem 552;Tween 18:0;Tween 60V;VykamolSorbitol 8B;
  • PSA 133.14000
  • LogP 4.33900

Tween60 Consensus Reports

POLYSORBATE 60(9005-67-8) is reported in EPA TSCA Inventory.

Tween60 Safety Profile

Moderately toxic by intravenous route. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Tween60 Specification

With the CAS registry number 9005, Tween60 is also named as Polyethylene glycol (3) sorbitan monostearate. The classification codes are Pharmaceutic aid [surfactant]; Reproductive Effect; TSCA Flag XU [Exempt from reporting under the Inventory Update Rule]; Tumor data. It is pale yellow waxy paste which should avoid contact with skin and eyes. And it is stable under normal temperature and pressure. Additionally, Tween60 should be stored in the cool and dry place.

Preparation of Tween60: It can be obtained by the addition reaction of Span-60 and ethylene oxide at the temperature of 130～170 °C and at the presence of sodium methoxide (or sodium ethoxide).

Uses of Tween60: It is a class of emulsifiers used in some pharmaceuticals and food preparation. It is often used in cosmetics to solubilize essential oils into water-based products. In addition, it is also used as defoamer, lubricant, cleaning agent, antistatic agent, solubilizer, dispersant, antistatic agent, stabilizer, lubricant and so on.

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intravenous 1gm/kg (1000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 685, 1956.
rat LD50 intravenous 1220mg/kg (1220mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.
rat LD50 oral > 60mL/kg (60mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.
rat LDLo intraperitoneal > 4gm/kg (4000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

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