Product Name

  • Name

    veratramine

  • EINECS
  • CAS No. 60-70-8
  • Article Data5
  • CAS DataBase
  • Density 1.14g/cm3
  • Solubility
  • Melting Point 122-1240C
  • Formula C27H39 N O2
  • Boiling Point 565°C at 760 mmHg
  • Molecular Weight 409.612
  • Flash Point 86.2°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 60-70-8 (veratramine)
  • Hazard Symbols
  • Synonyms Veratraman-3,23-diol,14,15,16,17-tetradehydro-, (3b,23b)-; Veratramine (7CI,8CI);1H-Benzo[a]fluorene, veratraman-3,23-diol deriv.; NSC 17821; NSC 23880
  • PSA 52.49000
  • LogP 4.92330

Veratramine Chemical Properties

IUPAC Name: (2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol
Synonyms: Veratramine ; Vreaframine ; (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol ; (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula of Veratramine (CAS NO.60-70-8) : C27H39NO2
Molecular Weight: 409.6041 g/mol
Structure of  Veratramine (CAS NO.60-70-8) :

Index of Refraction: 1.601
Surface Tension: 50.5 dyne/cm
Density: 1.14 g/cm3
Flash Point: 86.2 °C
Enthalpy of Vaporization: 89.29 kJ/mol
Boiling Point: 565 °C at 760 mmHg
Vapour Pressure: 1.33E-13 mmHg at 25°C 
Melting point: 122-1240°C
Appearance: White Solid
 

Veratramine Uses

 Veratramine (CAS NO.60-70-8) is useful as signal transduction inhibitor for treating tumors.

Veratramine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 3100ug/kg (3.1mg/kg)   Cesko-Slovenska Farmacie. Vol. 2, Pg. 418, 1953.
 
mouse LD50 subcutaneous 4500ug/kg (4.5mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955.
 
rabbit LDLo oral 33mg/kg (33mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Teratology, The International Journal of Abnormal Development. Vol. 3, Pg. 175, 1970.
 

Veratramine Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition  Veratramine (CAS NO.60-70-8) emits toxic fumes of NOx.

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