Product Name

  • Name

    Vindesine sulfate

  • EINECS 261-984-7
  • CAS No. 59917-39-4
  • Density 1.41 g/cm3
  • Solubility
  • Melting Point >250oC
  • Formula C43H55N5O7.H2SO4
  • Boiling Point
  • Molecular Weight 852.018
  • Flash Point
  • Transport Information
  • Appearance Amorphous solid
  • Safety 26-36
  • Risk Codes 40
  • Molecular Structure Molecular Structure of 59917-39-4 (Vindesine sulfate)
  • Hazard Symbols HarmfulXn
  • Synonyms Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);4-Desacetilvinblastina-C-3-carboxamida sulfato [Spanish];Fildesin (TN);Vindesine sulfate salt;Vindesine sulfate [USAN:JAN];Vindesine sulfate (JAN/USAN);Vindesina sulfato [Spanish];Fildesin;Desacetylvinblastine amide sulfate, compd. with mannitol;Lilly 99094;Desacetylvinblastine amide sulfate compound with mannitol;DAVA;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate (1:1) (salt);Eldesine;3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt), mixt. with D-mannitol;Eldisine;23-Amino-O(sup 4)-deacetyl-23-demethoxyvincaleukoblastine sulfate;Vincaleukoblastine, 3-(aminocarbonyl)-O(sup 4)-deacetyl-3-de(methoxycarbonyl)-, sulfate (1:1) (salt);Vincaleukoblastine,3-(aminocarbonyl)-O4- deacetyl-3-de(methoxycarbonyl)-,sulfate (1:1) (salt);Desacetylvinblastine amide sulfate;Vincaleukoblastine, 23-amino-O(sup 4)-deacetyl-23-demethoxy-, sulfate;
  • PSA 247.80000
  • LogP 3.80150

Vindesine sulfate Chemical Properties

The molecular structure of Vindesine sulfate (59917-39-4) as follow:

EINECS: 261-984-7
Molecular formula: C43H57N5O11S
Formula weight: 852
Synonyms: 23-amino-o(sup4)-deacetyl-23-demethoxyvincaleukoblastine sulfate ; 23-amino-o(sup4)-deacetyl-23-demethoxy-vincaleukoblastin sulfate ; 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate ; 4-desacetilvinblastina-c-3-carboxamida sulfato ; desacetylvinblastine amide sulfate ; eldesine ; eldisine
Melting point: >250 ℃ 
Appearance: Amorphous solid
The product categories about vindesine sulfate (59917-39-4) belong to intermediates & fine chemicals; pharmaceuticals.

Vindesine sulfate Uses

 Vindesine sulfate (59917-39-4) is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. It is used as a kind of anticancer drugs and the extensive usage is applied in antineoplastic combined chemotherapy protocols.

Vindesine sulfate Toxicity Data With Reference

mouse LD50 intraperitoneal 3500ug/kg (3.5mg/kg) BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
mouse LD50 intravenous 6300ug/kg (6.3mg/kg)   Journal of Toxicology and Environmental Health. Vol. 1, Pg. 843, 1976.
mouse LD50 subcutaneous 6800ug/kg (6.8mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 intraperitoneal 1050ug/kg (1.05mg/kg) BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 intravenous 1920ug/kg (1.92mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: NORMOCYTIC ANEMIA
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 subcutaneous 1790ug/kg (1.79mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.

Vindesine sulfate Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Hazard codes: Xn Harmful
Risk statements: 40 Limited evidence of a carcinogenic effect. 
Safety statements: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                           36 Wear suitable protective clothing. 

Vindesine sulfate Specification

 Vindesine sulfate (59917-39-4) should be stored at 2-8 ℃. As an anticancer drug, the major side effects of it are myelosuppression and neurotoxicity.

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