Product Name

  • Name

    Zipeprol dihydrochloride

  • EINECS 252-192-2
  • CAS No. 34758-84-4
  • Density 1.108g/cm3
  • Solubility
  • Melting Point 231°
  • Formula C23H32 N2 O3 . 2 Cl H
  • Boiling Point 507.7°Cat760mmHg
  • Molecular Weight 440.46
  • Flash Point 260.8°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NOx and ClH.
  • Risk Codes
  • Molecular Structure Molecular Structure of 34758-84-4 (Zipeprol dihydrochloride)
  • Hazard Symbols
  • Synonyms 1-Piperazineethanol,4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-, dihydrochloride (9CI); 3024CERM; Antituxil Z;CERM 3024; Citizeta; Mirsol; Respilene; Respirase; Zipeprol dihydrochloride;Zitoxil
  • PSA 45.17000
  • LogP 4.22010

Zipeprol dihydrochloride Chemical Properties

IUPAC Name: 1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol dihydrochloride
Synonyms: 1-Methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol dihydrochloride ; 1-Piperazineethanol, 4-(2-methoxy-2-phenylethyl)-alpha-(methoxyphenylmethyl)-, hydrochloride (1:2) ; 1-(2-Hydroxy-3-methoxy-3-phenylpropyl)-4-(2-methoxy-2-phenylethyl)piperazine dihydrochloride ; 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)propylpiperazine dihydrochlroide
CAS NO:34758-84-4
Molecular Formula of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :C23H34Cl2N2O3
Molecular Weight of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :457.43
Molecular Structure of 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) :
EINECS: 252-192-2
Flash Point: 260.8 °C
Enthalpy of Vaporization: 81.9 kJ/mol
Boiling Point: 507.7 °C at 760 mmHg
Vapour Pressure: 3.95E-11 mmHg at 25°C 
Melting point: 231°C
Appearance:White crystal or crystalline powder, odorless, bitter taste.
Solubility:Soluble in water and methanol

Zipeprol dihydrochloride Uses

 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydro-xy-3-methoxy-3-phenyl)propyl-piperazine dihydrochloride (CAS NO.34758-84-4) is used for cough by various causes .

Zipeprol dihydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 154mg/kg/3D-I (154mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.
dog LD50 oral 228mg/kg (228mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
dog LDLo intravenous 54600ug/kg (54.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
human TDLo oral 11mg/kg (11mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA		 Lancet. Vol. 1, Pg. 45, 1984.
man TDLo oral 10714ug/kg (10.714mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.
mouse LD50 intraperitoneal 116mg/kg (116mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse LD50 intravenous 44300mg/kg (44300mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse LD50 oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
mouse LD50 subcutaneous 158mg/kg (158mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rabbit LD50 oral 173mg/kg (173mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 intraperitoneal 77600ug/kg (77.6mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 intravenous 32700ug/kg (32.7mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 oral 435mg/kg (435mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 subcutaneous 139mg/kg (139mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
women TDLo oral 18mg/kg (18mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.

Zipeprol dihydrochloride Safety Profile

Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NOx and ClH.

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