beta-Phenylethylhydrazine sulfate supplier

Name
PHENELZINE SULFATE SALT
EINECS
CAS No. 156-51-4
Density
Solubility
Melting Point 166.5-167.5 °C
Formula C₈H₁₂N₂•H₂O₄S
Boiling Point 497.4°C at 760 mmHg
Molecular Weight 234.276
Flash Point 254.6°C
Transport Information
Appearance
Safety Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms phenelzinehydrogensulphate
PSA 121.03000
LogP 2.21160

Synthetic route

: 54123-21-6
3-(pyridine-2-yl)-3-oxopropanenitrile

: 156-51-4
2-phenethylhydrazine sulfate

: 1316122-43-6
2-phenethyl-5-pyridin-2-yl-2H-pyrazol-3-ylamine

Conditions

Conditions	Yield
With triethylamine In ethanol for 2h; Inert atmosphere; Reflux;	87%
With triethylamine In ethanol at 20℃; for 2h; Inert atmosphere; Reflux;	87%

: 156-51-4
2-phenethylhydrazine sulfate

: 94-05-3
ethyl (ethoxymethylene)cyanoacetate

: ethyl 3-amino-1-phenethyl-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With sodium ethanolate In tetrahydrofuran; ethanol at 0℃; Inert atmosphere; regioselective reaction;	81%

: gadolinium(III) sulfate hydrate

: 156-51-4
2-phenethylhydrazine sulfate

: Gd(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Gd(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	75%

: C21H31N9O5S

: 156-51-4
2-phenethylhydrazine sulfate

: C29H44N12O5S

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	73%

: 156-51-4
2-phenethylhydrazine sulfate

: 237421-80-6
4-(2-tert-butoxycarbonyl-2-oxo-ethyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester

: 4-[2-tert-butoxycarbonyl-2-(phenethyl-hydrazono)-ethyl]-5-oxo-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester

Conditions

Conditions	Yield
With sodium acetate In methanol for 2h; Ambient temperature;	70%

: 2Sm(3+)*3SO4(2-)*99H2O = Sm2(SO4)3*99H2O

: 156-51-4
2-phenethylhydrazine sulfate

: Sm(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Sm(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	70%

: 2Eu(3+)*3SO4(2-)*99H2O = Eu2(SO4)3*99H2O

: 156-51-4
2-phenethylhydrazine sulfate

: Eu(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Eu(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	70%

: 2Nd(3+)*3SO4(2-)*99H2O = Nd2(SO4)3*99H2O

: 156-51-4
2-phenethylhydrazine sulfate

: Nd(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Nd(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	68%

: hydrated cerium(III) sulfate

: 156-51-4
2-phenethylhydrazine sulfate

: Ce(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Ce(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	67%

: 156-51-4
2-phenethylhydrazine sulfate

: 94-05-3
ethyl (ethoxymethylene)cyanoacetate

: 252903-25-6
ethyl 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-phenethylhydrazine sulfate With sodium ethanolate In ethanol at 20℃; for 1h; Inert atmosphere; Stage #2: ethyl (ethoxymethylene)cyanoacetate In ethanol at 0 - 70℃; for 14.5h; Inert atmosphere; regioselective reaction;	67%

: lanthanum(III) sulphate hydrate

: 156-51-4
2-phenethylhydrazine sulfate

: La(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [La(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	63%

: 2Pr(3+)*3SO4(2-)*99H2O = Pr2(SO4)3*99H2O

: 156-51-4
2-phenethylhydrazine sulfate

: Pr(3+)*2SO4(2-)*2H2O*C6H5CH2CH2NH2NH2(1+) = [Pr(SO4)2(H2O)2(C6H5CH2CH2NH2NH2)]

Conditions

Conditions	Yield
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.;	61%

: 740842-28-8
(S)-N-[2-oxo-3-(5-oxo-2,3,4,5-tetrahydro-benzo[b]oxepin-8-yl)-oxazolidin-5-ylmethyl]-acetamide

: 156-51-4
2-phenethylhydrazine sulfate

A: (S)-N-[3-(2-phenethyl-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

B: (S)-N-[3-(1-phenethyl-4,5-dihydro-1H-6-oxa-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Conditions

Conditions	Yield
With triethylamine In ethanol at 20℃; for 20h;

...Expand

: 156-51-4
2-phenethylhydrazine sulfate

: benzaldehyde (2-phenylethyl)hydrazone

Conditions

Conditions	Yield
With sodium hydroxide; benzaldehyde In ethanol

: (E)-2(R)-[1(S)-(tert.-butoxycarboxycarbonyl)-4-phenyl-3-butenyl]-4-methylvaleric acid

: 156-51-4
2-phenethylhydrazine sulfate

: 253795-02-7
(E)-2(R)-[1(S)-(tert-butoxy-carbonyl)-4-phenyl-3-butenyl]-4-methyl-2'-(2-phenylethyl)valerohydrazide

: C20H29N3O3

: 156-51-4
2-phenethylhydrazine sulfate

A: 1092481-46-3
C26H32N4O2

B: 1092481-47-4
C26H32N4O2

Conditions

Conditions	Yield
Stage #1: 2-phenethylhydrazine sulfate With ethanol; sodium at 20℃; for 0.333333h; Stage #2: C20H29N3O3 In ethanol at 85℃; for 144h; Product distribution / selectivity;

...Expand

: 29681-98-9
p-fluorobenzoylacetone

: 156-51-4
2-phenethylhydrazine sulfate

: 1221503-87-2
5-(4-fluorophenyl)-3-methyl-1-(2-phenylethyl)-1H-pyrazole

Conditions

Conditions	Yield
With triethylamine; trifluoroacetic acid In isopropyl alcohol at 80℃; for 2h;

: 102126-70-5
5-bromo-3-bromo-3H-isobenzofuran-1-one

: 156-51-4
2-phenethylhydrazine sulfate

: 1251402-12-6
6-bromo-2-phenethyl-1-phthalazinone

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol at 20℃;

: 156-51-4
2-phenethylhydrazine sulfate

: 1562528-42-0
methyl 2-(2-carbamothioyl-2-phenethylhydrazinyl)-2-oxoacetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 50 h / 78 °C 2: tetrahydrofuran / 14 h / 20 °C View Scheme

: 156-51-4
2-phenethylhydrazine sulfate

: 1562528-36-2
6-hydroxy-2-phenethyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ethanol / 50 h / 78 °C 2: tetrahydrofuran / 14 h / 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 14.5 h / 20 - 50 °C View Scheme

beta-Phenylethylhydrazine sulfate Chemical Properties

IUPAC Name: Phenethylhydrazine; sulfuric acid
Synonyms: Phenelzine hydrogen sulphate ; (2-Phenethyl)hydrazine Dihydrogen Sulfate ; (2-Phényléthyl)hydrazine sulfate ; (2-Phenylethyl)hydrazine sulfate (1:1) ; (2-Phenylethyl)hydrazinsulfat ; B-Phenylethylhydrazine Dihydrogen Sulfate ; Hydrazine, (2-phenylethyl)-, sulfate (1:1)
Product Categories: Monoamine oxidase inhibitor;Monoamine OxidaseEnzyme Inhibitors by Enzyme;Enzyme Inhibitors;L to;Neurotransmitter Metabolism
CAS NO: 156-51-4
Molecular Formula of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) : C₈H₁₄N₂O₄S
Molecular Weight of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) : 234.27
Molecular Structure of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) :
EINECS: 205-856-0
Mol File: 156-51-4.mol
Merck : 13,7300
Flash Point: 143.7 °C
Enthalpy of Vaporization: 52.02 kJ/mol
Boiling Point: 281.4 °C at 760 mmHg
Vapour Pressure: 0.00358 mmHg at 25°C

beta-Phenylethylhydrazine sulfate Toxicity Data With Reference

1.	mma-sat 800 µg/plate	NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. 33 (1978),474.
2.	dnr-esc 4300 nmol/plate	JTEHD6 Journal of Toxicology and Environmental Health. 9 (1982),287.
3.	orl-mus TDLo:28 g/kg/77W-C:NEO	CNREA8 Cancer Research. 36 (1976),917.
4.	orl-hmn TDLo:1070 µg/kg/D:CNS,GIT,CVS	34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,461.
5.	orl-man TDLo:46 mg/kg/10W-I:LIV,	AJMEAZ American Journal of Medicine. 80 (1986),689.
6.	orl-wmn TDLo:18 mg/kg	ANASAB Anaesthesia. 41 (1986),53.
7.	orl-rat LD50:210 mg/kg	ANYAA9 Annals of the New York Academy of Sciences. 107 (1963),899.
8.	orl-mus LD50:156 mg/kg	ANYAA9 Annals of the New York Academy of Sciences. 107 (1963),899.
9.	ipr-mus LD50:162 mg/kg	JMCMAR Journal of Medicinal Chemistry. 18 (1975),20.
10.	scu-mus LD50:125 mg/kg	JOENAK Journal of Endocrinology. 30 (1964),205.

beta-Phenylethylhydrazine sulfate Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 312.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

beta-Phenylethylhydrazine sulfate Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes Harmful Xn
Risk Statements 22
R22:Harmful if swallowed.
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS MV8750000
HazardClass 6.1(b)
PackingGroup III

Product Name

PHENELZINE SULFATE SALT

Synthetic route

beta-Phenylethylhydrazine sulfate Chemical Properties

beta-Phenylethylhydrazine sulfate Toxicity Data With Reference

beta-Phenylethylhydrazine sulfate Consensus Reports

beta-Phenylethylhydrazine sulfate Safety Profile

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