l-Threitol-1,4-bismethanesulfonate supplier

Name
treosulfan
EINECS 206-081-0
CAS No. 299-75-2
Article Data11
CAS DataBase
Density 1.562g/cm³
Solubility
Melting Point 76-78 °C
Formula C6H14 O8 S2
Boiling Point 607°Cat760mmHg
Molecular Weight 278.304
Flash Point 320.9°C
Transport Information
Appearance
Safety Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1,2,3,4-Butanetetrol,1,4-dimethanesulfonate, [S-(R*,R*)]-;Threitol, 1,4-dimethanesulfonate,(2S,3S)- (8CI);(2S,3S)-Threitol 1,4-bismethanesulfonate;L-Threitol1,4-bis(methanesulfonate);NSC 39069;Ovastat;Threosulphan;Treosulfan;Treosulphan;Tresulfan;
PSA 143.96000
LogP -0.17780

l-Threitol-1,4-bismethanesulfonate Chemical Properties

IUPAC Name: (2,3-Dihydroxy-4-methylsulfonyloxybutyl) methanesulfonate
Synonyms: 1,2,3,4-1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,R*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,S*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))- (9CI) ; 2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
CAS NO: 299-75-2
Molecular Formula of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :C₆H₁₄O₈S₂
Molecular Weight of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :278.3006
Molecular Structure of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :
EINECS: 206-081-0
Index of Refraction: 1.517
Surface Tension: 64.4 dyne/cm
Density: 1.562 g/cm³
Flash Point: 320.9 °C
Enthalpy of Vaporization: 103.49 kJ/mol
Boiling Point: 607 °C at 760 mmHg
Vapour Pressure: 2.86E-17 mmHg at 25°C
Appearance:Odorless white crystalline powder.

l-Threitol-1,4-bismethanesulfonate Uses

l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) is mainly used in the clinical treatment of ovarian cancer, but also for treatment of tumor resection after adjuvant therapy.

l-Threitol-1,4-bismethanesulfonate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	222mg/kg (222mg/kg)	GASTROINTESTINAL: OTHER CHANGES BLOOD: LEUKOPENIA BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
monkey	LDLo	intravenous	222mg/kg (222mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.

l-Threitol-1,4-bismethanesulfonate Consensus Reports

IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 363.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 341.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

l-Threitol-1,4-bismethanesulfonate Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SO_x.
RIDADR 2811
HazardClass 6.1(b)
PackingGroup III

l-Threitol-1,4-bismethanesulfonate Specification

1.Air & Water Reactions :Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
2.Fire Hazard :Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Product Name

treosulfan