Product Name

  • Name

    METHACHOLINE CHLORIDE

  • EINECS 200-537-2
  • CAS No. 62-51-1
  • Density 1.1028 (rough estimate)
  • Solubility Soluble in water : 50 mg/mL
  • Melting Point 171-173 °C(lit.)
  • Formula C8H18 N O2 . Cl
  • Boiling Point
  • Molecular Weight 195.689
  • Flash Point
  • Transport Information
  • Appearance White hygroscopic crystals with slight odor of dead fish.
  • Safety Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by other routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 62-51-1 (METHACHOLINE CHLORIDE)
  • Hazard Symbols HarmfulXn
  • Synonyms (2-Hydroxypropyl)trimethylammoniumchloride acetate (6CI); 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-,chloride (9CI); Ammonium, (2-hydroxypropyl)trimethyl-, chloride, acetate (8CI);(2-Acetoxypropyl)trimethylammonium chloride; (?à)-Acetyl-b-methylcholine chloride; Acetyl-b-methylcholine chloride; Amechol; DL-Acetyl-b-methylcholine chloride; Mecholinechloride; Mecholyl; Methacholine chloride; Methacholinium chloride; O-Acetyl-b-methylcholine chloride;Provocholine; Trimethyl-b-acetoxypropylammonium chloride; b-Methylacetylcholine chloride
  • PSA 26.30000
  • LogP -2.35180

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

(+/-)-(2-hydroxy-propyl)-trimethyl-ammonium; chloride
2382-43-6

(+/-)-(2-hydroxy-propyl)-trimethyl-ammonium; chloride

metacholine chloride
62-51-1

metacholine chloride

Conditions
ConditionsYield
at 100℃;

o-ACETYL-β-METHYLCHOLINE CHLORIDE Chemical Properties

Product Name: 0-acetyl-β-methylcholine chloride viki  (62-51-1)


Molecular Formula: C8H18ClNO2
Molecular Weight: 195.69g/mol
Mol File: 62-51-1.mol
Einecs: 200-537-2
Appearance: White hygroscopic crystals with slight odor of dead fish
Melting Point: 171-173 °C(lit.)
Storage Temperature: 2-8°C
Water Solubility: H2O: 50 mg/mL, clear, colorless
Product Categories: Ammonium Chlorides (Quaternary); Quaternary Ammonium Compounds
Synonyms of  0-acetyl-β-methylcholine chloride viki (62-51-1): methacholine chloride ; mecholyl chloride ; acetyl-2-methylcholine chloride ; acetyl-beta-methylcholine chloride ; acetyl-b-methylcholine chloride ; (2-hydroxypropyl)trimethylammonium chloride acetate ; 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminium chloride ; (2-acetoxypropyl)trimethylammonium chloride .

o-ACETYL-β-METHYLCHOLINE CHLORIDE Toxicity Data With Reference

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by other routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 3750ug/kg (3.75mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 245, 1956.
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
mouse LD50 intravenous 15mg/kg (15mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
mouse LD50 oral 740mg/kg (740mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 210, 1959.
mouse LD50 subcutaneous 90mg/kg (90mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 intravenous 20mg/kg (20mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 oral 750mg/kg (750mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 subcutaneous 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.

o-ACETYL-β-METHYLCHOLINE CHLORIDE Consensus Reports

Reported in EPA TSCA Inventory.

o-ACETYL-β-METHYLCHOLINE CHLORIDE Safety Profile

Safety Information of 0-acetyl-β-methylcholine chloride viki (62-51-1):
Hazard Codes: Xn
Risk Statements: 22-36/37/38
22:  Harmful if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing

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