-
Name
2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE
- EINECS
- CAS No. 83-98-7
- Article Data6
- CAS DataBase
- Density 1.0278 (rough estimate)
- Solubility 1.801mg/L(22.5 oC)
- Melting Point 25°C
- Formula C18H23 N O
- Boiling Point bp12 195°
- Molecular Weight 269.387
- Flash Point
- Transport Information
- Appearance
- Safety Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: convulsions, coma, arrhythmias, pulse rate increase and blood pressure elevation. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Ethylamine,N,N-dimethyl-2-[(o-methyl-a-phenylbenzyl)oxy]- (8CI); (?à)-Orphenadrine; 2-Methyldiphenhydramine; BS 5930; Biorphen; Brocadisipal;N,N-Dimethyl-2-(o-methyl-a-phenylbenzyloxy)ethylamine; N,N-Dimethyl-N-[2-(o-methyl-a-phenylbenzyloxy)ethyl]amine;ORP; Orphenadine; Orphenadrin; Orphenadrine; Phenyl-o-tolylmethyldimethylaminoethyl ether; WS 2434; o-Methyldiphenhydramine
- PSA 12.47000
- LogP 3.66260
o-METHYLDIPHENHYDRAMINE Chemical Properties
Product Name: O-methyldiphenhydramine (83-98-7)
Molecular Formula: C18H23NO
Molecular Weight: 269.38g/mol
Mol File: 83-98-7.mol
Einecs: 201-509-2
Appearance: Liquid
Boiling point: 363 °C at 760 mmHg
Flash Point: 107.1 °C
Density: 1.014 g/cm3
Synonyms of O-methyldiphenhydramine (83-98-7): 2-(phenyl-o-tolylmethoxy)ethyldimethylamine ; phenyl-o-tolylmethyl dimethylaminoethyl ether ; aurora ka-7797 ; b-dimethylaminoethyl 2-methylbenzhydryl ether ; 2-(phenyl-o-tolylmethoxy)ethyldimethylamine ; 2-methyldiphenhydramine ; beta-dimethylaminoethyl-2-methylbenzhydryl ether ; biorphen .
o-METHYLDIPHENHYDRAMINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 14mg/kg (14mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41(2), Pg. 137, 1977. |
| human | TDLo | oral | 7143mg/kg (7143mg/kg) | BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | Archives of Toxicology, Supplement. Vol. 4, Pg. 425, 1980. |
| mouse | LD50 | intraperitoneal | 80mg/kg (80mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962. |
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962. |
| mouse | LD50 | oral | 125mg/kg (125mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962. |
| mouse | LD50 | subcutaneous | 150mg/kg (150mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962. |
o-METHYLDIPHENHYDRAMINE Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: convulsions, coma, arrhythmias, pulse rate increase and blood pressure elevation. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
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