Cholic Acid good s...

Cholic Acid good supplier 81-25-4 with fast delivery Hot sale 81-25-4

Cholic Acid good supplier 81-25-4 with fast delivery Hot sale 81-25-4

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25 Kilogram

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  • Min.Order :25 Kilogram
  • Purity: HPLC≥98.0%
  • Payment Terms : L/C,T/T

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Cholic Acid good supplier 81-25-4 with fast delivery Hot sale 81-25-4

Quick Details

  • Appearance:extracted from bovine and rabbit bile
  • Application:Effect and use: increase blood lipid content, raise blood pressure, relieve cough, strengthen heart, and strong hemolysis, anti-inflammatory effect.
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Cholic Acid  good supplier 81-25-4  with fast delivery Hot sale 81-25-4
Source: extracted from bovine and rabbit bile

Quality standard：HPLC≥98.0%.

Effect and use: increase blood lipid content, raise blood pressure, relieve cough, strengthen heart, and strong hemolysis, anti-inflammatory effect.

Properties 
Appearance & Physical State: white to off-white crystalline powder
Density: 1.184g/cm3
Melting Point: 197-202ºC
Boiling Point: 545ºC
Flash Point: 321ºC
Refractive Index: 1.558
Water Solubility: 0.28 g/L (15 ºC)
Stability: Stable under normal temperatures and pressures.
Storage Condition: Store at RT.

 

 

Application

(1) It can emulsify fat and improve its function of digestion as a kind of organic acid.
(2) It can be applied in emulgator.
(3) It can be applied in the research of biochemistry as a kind of medical intermediate.
(4) It can be applied in non ion-modified detergent to extract membrane protein.
(5) It is mainly used as medicine raw materials.
(6) The cholesterol is still the raw material of cosmetics, and a good surfactant of medicine products. It can also be used for additive of animal feed.

Function

(1) It can treat cholecystitis, the lack of bile, intestinal indigestion and gallstones etc.
(2) It can prevent and treat liver diseases.
(3) It is a kind of organic acid and can be used to produce vitamin D2 and D3.

 

 

 

NAME: Cholic Acid HPLC≥ 98.0% CHEMICAL NAME: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid FORMULA :C24H40O5 MOLECULAR WEIGHT : 408.58 CAS …

Safety Info
Symbol:
GHS07
Sign: Warning
hazard declaration: H315; H319
hazard declaration add:  
waring notice: P305 + P351 + P338
RTECS: FZ9350000
Safety Statements: S24/25
HS Code: 2942000000
WGK Germany: 2
Risk Statements: R36/37/38
Hazard Codes: Xi
Cholic acid Basic information
Chemical properties Uses Identification test Analysis of the content Toxicity Production methods
Product Name: Cholic acid
Synonyms: Ursodeoxycholic Acid EP Impurity B;(4R)-4-((3R,5S,7R,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;3,7,12-Trihydroxy-cholan-24-oic acid;Cholic acid from pure ox bile;Cholic acid from bovine and sheep;Chenodeoxycholic Acid Impurity 2;5beta-Cholan-24-oic acid, 3alpha,7alpha,12alpha-trihydroxy-;Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-
CAS: 81-25-4
MF: C24H40O5
MW: 408.57
EINECS: 201-337-8
Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File: 81-25-4.mol
Cholic acid Structure
Cholic acid Chemical Properties
Melting point  200-201 °C(lit.)
alpha  36 º (c=0.6, 95% EtOH)
Boiling point  449.08°C (rough estimate)
density  1.0310 (rough estimate)
refractive index  1.5800 (estimate)
Fp  9℃
storage temp.  Store at RT.
solubility  methanol: 0.1 g/mL, clear
pka 4.98(at 20℃)
Water Solubility  0.28 g/L (15 ºC)
Merck  14,2203
BRN  2822009
CAS DataBase Reference 81-25-4(CAS DataBase Reference)
NIST Chemistry Reference Cholic acid(81-25-4)
EPA Substance Registry System Cholan-24-oic acid, 3,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha., 12.alpha.)-(81-25-4)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  FZ9350000
TSCA  Yes
Hazardous Substances Data 81-25-4(Hazardous Substances Data)
MSDS Information
Provider Language
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid English
ACROS English
SigmaAldrich English
ALFA English
Cholic acid Usage And Synthesis
Chemical properties This agent exist in the bile cattle, sheep, pig. It is a colorless sheet or white crystalline powder. Some have a bitter to sweet taste. Its melting point is 198℃, specific rotation is (c = 0.6, ethanol) +37°. 1g cholic acid dissolved in about 300ml ethanol or acetone, 7ml glacial acetic acid. A small amount of cholic acid is soluble in water. The monohydrate was a white flake crystal. In 1927, H.Wieland (Germany) research accomplished bile acid composition, and won the Nobel Prize in chemistry.
Uses (1) Emulsifiers.
(2) Used for biochemical research, as pharmaceutical intermediates. Sodium cholate is a cholagogue, for the treatment of cholecystitis, bile deficiency, intestinal indigestion embolism.
(3) As organic acids with steroid structure, cholic acid can emulsify fat, promote its digestion.
(4) Non-denaturing ionic detergents for the extraction of membrane proteins.
Identification test Solubility: hardly insoluble in water; soluble in ethanol. According to OT-42 method.
The melting range : 197~202 ℃. As determined by conventional methods.
Add 50% acetic acid solution to prepare 0.02% of the sample solution; take 1ml, 1% furfural solution, 6ml of water and concentrated sulfuric acid 5ml. This mixture should be converted into rosiness in 5min and then turn purple.
Take about 10mg sample, add 2 drops of benzaldehyde and 3: 1 sulfuric acid 3 drops, heating at 50 ℃ for 5min. Plus glacial acetic acid about 10ml, then it should be brown.
Analysis of the content Weigh about 400mg of the sample accurately; dried at 140 ℃ for 4h; put it into a 250ml flask; add 20ml of water and 40ml of ethanol; cover the surface dish, and gently heat to dissolve and cool in the steam bath. Add 5 drops of phenolphthalein test solution (TS-167), titrate with 0.1mol/L sodium hydroxide solution to pink and keep 15s, and make the necessary correction with the same time blank test. Each 1ml of 0.1 mol/L sodium hydroxide corresponds to 40.86 mg of cholic acid (C24 H40O5).
Toxicity ADI O～1.25mg/kg(FAO/WH0，2001)。
ADI O~1.25 mg/kg (FAO/WH0, 2001)。
Production methods (1) Extracting from livestock (pigs, cattle, sheep, rabbits) the bile.
1.Ethanol crystallization method
Preparation of crude cholic acid of cattle, sheep: take bovine or sheep bile; add 100 g/L sodium hydroxide; heat to boil for 12-18h to get saponification solution. Cooling. Adding acid to pH 1, precipitating cholic acid, removing bile acid, undergoing boiling and rinsing, drying at 75℃, milling can obtain bovine cholic acid.
sodium cholate[NaOH] → [100 ℃, 12-18h] saponified solution[H2SO4] → [pH1, 75 ℃] crude cholic acid of cattle, sheep.
Preparation of sodium cholate: add 0.5-1 times of crude cholic acid to 95% ethanol, and dissolve the solids by heating reflux method; cool. Broke the crystallization; filter; add 95% washing ethanol to make the filtrate colorless. Crystallize by adding 4 times the amount of ethanol; add 100-150g/L of activated carbon; dissolve the solids by heating reflux method; filter the liquid when it is hot. The filtrate concentrated to the original volume of 1/4. Through cooling, crystallization, filtration, adding ethanol to wash the crystallization can obtain the sodium cholate products.
Crude cholic acid cattle, sheep [ethanol, activated carbon] → refined liquid [90 ℃ below] → sodium cholate products
2.  Ethyl acetate separation method
Preparation of crude hyocholic acid: Add 3-3.5 times of saturated lime supernatant into fresh pig bile under stirring, then continue to stir it for 5-10min. heating to boiling for 2min, cooling, through filtration, adding hydrochloric acid to PH3.5 to get precipitation, standing for more than 12h can obtain crude acid. Removing, washing, adding 1.5 times the sodium hydroxide, plus 9 times the water, heating and boiling 12-18h, cooling, standing overnight obtain paste. Add water and sulfuric acid to pH 1 to precipitate pig cholic acid. Removing, crushing, rinsing to no acidity, through filtration gains crude pig cholic acid.
[pig bile] [saturated limewater] →[100℃, pH 11-12] Basic filtrate [HCl] → [pH3.5] Crude cholic acid [water, NaOH] → paste [H2SO4] → [pH1] crude pig cholic acid
Preparation of pig cholic acid products: add 4 times the amount of ethyl acetate to the crude pig cholic acid. Add 150-200g/L activated carbon; heat and flux for 0.5h; cool; filter; add 1.5-2.5 times ethyl acetate to filter cake; combine the filtrates twice. Adding 200g/L anhydrous sodium sulfate, standing overnight, concentrated to the original volume of 1/3, releasing, cooling crystallization, through filtration, washing with ethyl acetate crystallization, drying can obtain pig cholic acid products.
Crude pig cholic acid [ethyl acetate, activated carbon] → filtrate [anhydrous sodium sulfate] → filtrate [concentration] → pig cholic acid products.
Chemical Properties white to light beige crystalline powder
Uses Choleretic produced by, and isolated from liver cells.
Uses asthma therapeutic
Uses Cholic Acid is an emulsifier that exists as colorless plates or a white crystalline powder which has a bitter taste with a sweetish aftertaste. it is slightly soluble in water. it functions as an emulsifying agent in egg white.
Definition ChEBI: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Purification Methods This bile acid crystallises from H2O or wet Et2O (as hydrate) or EtOH (as alcoholate). Dry it under vacuum at 94o. When an alcoholic solution of cholic acid + I2 is added to aqueous KI, it forms a molecular compound (C24H40O5I)4 KI. H2O. The methyl ester is dimorphic with m 155o and 162o and [] D 20 +25o (EtOH). [Anderson et al. Biochem J 67 323 1957, 85 236 1962, Beilstein 10 III 2162, IV 2071.]

 

Details:

Cholic Acid  good supplier 81-25-4  with fast delivery Hot sale 81-25-4
 

Cholic Acid good supplier 81-25-4 with fast delivery Hot sale 81-25-4

NAME: Cholic Acid HPLC≥ 98.0% CHEMICAL NAME: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid FORMULA :C24H40O5 MOLECULAR WEIGHT : 408.58 CAS NUMBER: 81-25-4

2.  Ethyl acetate separation method
Preparation of crude hyocholic acid: Add 3-3.5 times of saturated lime supernatant into fresh pig bile under stirring, then continue to stir it for 5-10min. heating to boiling for 2min, cooling, through filtration, adding hydrochloric acid to PH3.5 to get precipitation, standing for more than 12h can obtain crude acid. Removing, washing, adding 1.5 times the sodium hydroxide, plus 9 times the water, heating and boiling 12-18h, cooling, standing overnight obtain paste. Add water and sulfuric acid to pH 1 to precipitate pig cholic acid. Removing, crushing, rinsing to no acidity, through filtration gains crude pig cholic acid.
[pig bile] [saturated limewater] →[100℃, pH 11-12] Basic filtrate [HCl] → [pH3.5] Crude cholic acid [water, NaOH] → paste [H2SO4] → [pH1] crude pig cholic acid
Preparation of pig cholic acid products: add 4 times the amount of ethyl acetate to the crude pig cholic acid. Add 150-200g/L activated carbon; heat and flux for 0.5h; cool; filter; add 1.5-2.5 times ethyl acetate to filter cake; combine the filtrates twice. Adding 200g/L anhydrous sodium sulfate, standing overnight, concentrated to the original volume of 1/3, releasing, cooling crystallization, through filtration, washing with ethyl acetate crystallization, drying can obtain pig cholic acid products.
Crude pig cholic acid [ethyl acetate, activated carbon] → filtrate [anhydrous sodium sulfate] → filtrate [concentration] → pig cholic acid products.
Chemical Properties white to light beige crystalline powder
Uses Choleretic produced by, and isolated from liver cells.
Uses asthma therapeutic
Uses Cholic Acid is an emulsifier that exists as colorless plates or a white crystalline powder which has a bitter taste with a sweetish aftertaste. it is slightly soluble in water. it functions as an emulsifying agent in egg white.
Definition ChEBI: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Purification Methods This bile acid crystallises from H2O or wet Et2O (as hydrate) or EtOH (as alcoholate). Dry it under vacuum at 94o. When an alcoholic solution of cholic acid + I2 is added to aqueous KI, it forms a molecular compound (C24H40O5I)4 KI. H2O. The methyl ester is dimorphic with m 155o and 162o and [] D 20 +25o (EtOH). [Anderson et al. Biochem J 67 323 1957, 85 236 1962, Beilstein 10 III 2162, IV 2071.]
Cholic acid Basic information
Chemical properties Uses Identification test Analysis of the content Toxicity Production methods
Product Name: Cholic acid
Synonyms: Ursodeoxycholic Acid EP Impurity B;(4R)-4-((3R,5S,7R,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;3,7,12-Trihydroxy-cholan-24-oic acid;Cholic acid from pure ox bile;Cholic acid from bovine and sheep;Chenodeoxycholic Acid Impurity 2;5beta-Cholan-24-oic acid, 3alpha,7alpha,12alpha-trihydroxy-;Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-
CAS: 81-25-4
MF: C24H40O5
MW: 408.57
EINECS: 201-337-8
Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File: 81-25-4.mol
Cholic acid Structure
Cholic acid Chemical Properties
Melting point  200-201 °C(lit.)
alpha  36 º (c=0.6, 95% EtOH)
Boiling point  449.08°C (rough estimate)
density  1.0310 (rough estimate)
refractive index  1.5800 (estimate)
Fp  9℃
storage temp.  Store at RT.
solubility  methanol: 0.1 g/mL, clear
pka 4.98(at 20℃)
Water Solubility  0.28 g/L (15 ºC)
Merck  14,2203
BRN  2822009
CAS DataBase Reference 81-25-4(CAS DataBase Reference)
NIST Chemistry Reference Cholic acid(81-25-4)
EPA Substance Registry System Cholan-24-oic acid, 3,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha., 12.alpha.)-(81-25-4)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  FZ9350000
TSCA  Yes
Hazardous Substances Data 81-25-4(Hazardous Substances Data)
MSDS Information
Provider Language
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid English
ACROS English
SigmaAldrich English
ALFA English
Cholic acid Usage And Synthesis
Chemical properties This agent exist in the bile cattle, sheep, pig. It is a colorless sheet or white crystalline powder. Some have a bitter to sweet taste. Its melting point is 198℃, specific rotation is (c = 0.6, ethanol) +37°. 1g cholic acid dissolved in about 300ml ethanol or acetone, 7ml glacial acetic acid. A small amount of cholic acid is soluble in water. The monohydrate was a white flake crystal. In 1927, H.Wieland (Germany) research accomplished bile acid composition, and won the Nobel Prize in chemistry.
Uses (1) Emulsifiers.
(2) Used for biochemical research, as pharmaceutical intermediates. Sodium cholate is a cholagogue, for the treatment of cholecystitis, bile deficiency, intestinal indigestion embolism.
(3) As organic acids with steroid structure, cholic acid can emulsify fat, promote its digestion.
(4) Non-denaturing ionic detergents for the extraction of membrane proteins.
Identification test Solubility: hardly insoluble in water; soluble in ethanol. According to OT-42 method.
The melting range : 197~202 ℃. As determined by conventional methods.
Add 50% acetic acid solution to prepare 0.02% of the sample solution; take 1ml, 1% furfural solution, 6ml of water and concentrated sulfuric acid 5ml. This mixture should be converted into rosiness in 5min and then turn purple.
Take about 10mg sample, add 2 drops of benzaldehyde and 3: 1 sulfuric acid 3 drops, heating at 50 ℃ for 5min. Plus glacial acetic acid about 10ml, then it should be brown.
Analysis of the content Weigh about 400mg of the sample accurately; dried at 140 ℃ for 4h; put it into a 250ml flask; add 20ml of water and 40ml of ethanol; cover the surface dish, and gently heat to dissolve and cool in the steam bath. Add 5 drops of phenolphthalein test solution (TS-167), titrate with 0.1mol/L sodium hydroxide solution to pink and keep 15s, and make the necessary correction with the same time blank test. Each 1ml of 0.1 mol/L sodium hydroxide corresponds to 40.86 mg of cholic acid (C24 H40O5).
Toxicity ADI O～1.25mg/kg(FAO/WH0，2001)。
ADI O~1.25 mg/kg (FAO/WH0, 2001)。
Production methods (1) Extracting from livestock (pigs, cattle, sheep, rabbits) the bile.
1.Ethanol crystallization method
Preparation of crude cholic acid of cattle, sheep: take bovine or sheep bile; add 100 g/L sodium hydroxide; heat to boil for 12-18h to get saponification solution. Cooling. Adding acid to pH 1, precipitating cholic acid, removing bile acid, undergoing boiling and rinsing, drying at 75℃, milling can obtain bovine cholic acid.
sodium cholate[NaOH] → [100 ℃, 12-18h] saponified solution[H2SO4] → [pH1, 75 ℃] crude cholic acid of cattle, sheep.
Preparation of sodium cholate: add 0.5-1 times of crude cholic acid to 95% ethanol, and dissolve the solids by heating reflux method; cool. Broke the crystallization; filter; add 95% washing ethanol to make the filtrate colorless. Crystallize by adding 4 times the amount of ethanol; add 100-150g/L of activated carbon; dissolve the solids by heating reflux method; filter the liquid when it is hot. The filtrate concentrated to the original volume of 1/4. Through cooling, crystallization, filtration, adding ethanol to wash the crystallization can obtain the sodium cholate products.
Crude cholic acid cattle, sheep [ethanol, activated carbon] → refined liquid [90 ℃ below] → sodium cholate products
2.  Ethyl acetate separation method
Preparation of crude hyocholic acid: Add 3-3.5 times of saturated lime supernatant into fresh pig bile under stirring, then continue to stir it for 5-10min. heating to boiling for 2min, cooling, through filtration, adding hydrochloric acid to PH3.5 to get precipitation, standing for more than 12h can obtain crude acid. Removing, washing, adding 1.5 times the sodium hydroxide, plus 9 times the water, heating and boiling 12-18h, cooling, standing overnight obtain paste. Add water and sulfuric acid to pH 1 to precipitate pig cholic acid. Removing, crushing, rinsing to no acidity, through filtration gains crude pig cholic acid.
[pig bile] [saturated limewater] →[100℃, pH 11-12] Basic filtrate [HCl] → [pH3.5] Crude cholic acid [water, NaOH] → paste [H2SO4] → [pH1] crude pig cholic acid
Preparation of pig cholic acid products: add 4 times the amount of ethyl acetate to the crude pig cholic acid. Add 150-200g/L activated carbon; heat and flux for 0.5h; cool; filter; add 1.5-2.5 times ethyl acetate to filter cake; combine the filtrates twice. Adding 200g/L anhydrous sodium sulfate, standing overnight, concentrated to the original volume of 1/3, releasing, cooling crystallization, through filtration, washing with ethyl acetate crystallization, drying can obtain pig cholic acid products.
Crude pig cholic acid [ethyl acetate, activated carbon] → filtrate [anhydrous sodium sulfate] → filtrate [concentration] → pig cholic acid products.
Chemical Properties white to light beige crystalline powder
Uses Choleretic produced by, and isolated from liver cells.
Uses asthma therapeutic
Uses Cholic Acid is an emulsifier that exists as colorless plates or a white crystalline powder which has a bitter taste with a sweetish aftertaste. it is slightly soluble in water. it functions as an emulsifying agent in egg white.
Definition ChEBI: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Purification Methods This bile acid crystallises from H2O or wet Et2O (as hydrate) or EtOH (as alcoholate). Dry it under vacuum at 94o. When an alcoholic solution of cholic acid + I2 is added to aqueous KI, it forms a molecular compound (C24H40O5I)4 KI. H2O. The methyl ester is dimorphic with m 155o and 162o and [] D 20 +25o (EtOH). [Anderson et al. Biochem J 67 323 1957, 85 236 1962, Beilstein 10 III 2162, IV 2071.]

 

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