Resatorvid TAK-242 Resatorvid (TAK-242)
Resatorvid (TAK-242) is a potent TLR4 signaling inhibitor which selectively inhibits the TLR4-mediated production of cytokines and nitric oxide.
Product Name: Resatorvid (TAK-242)
CAS No.:243984-11-4
Synonyms: (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester
Molecular Formula: C15H17ClFNO4S
Molecular Weight: 361.82
Appearance: Light yellow solid
Purity: >98%; ee,>98% by HPLC
Solubility: DMSO
Storage: at -20°C 2 years; Store in a tightly closed container, in a cool and dry place.
Biological Activity of TAK-242:
TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling. TAK-242 is in treatment of sepsis and septic shock.TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
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