Crisaborole 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole Eucrisa
Our company has commercialized this product for long-term stable supply, the purity ≥ 99.5%. At present, our sales of this product have reached more than 670 kg
Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reducing the signs and symptoms in patients 2 years old and older. It reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. It is currently under development as topical treatment of psoriasis.
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