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DEET N,N-Diethyl-m-toluamide low price global
factory CAS 134-62-3 N,N-Diethyl-3-methylbenzamide
【 summary 】
DEET, also known as diethyl toluamide, is a broad-spectrum insect repellent that can repel a variety of biting insects in a variety of environments. It can repel stinging flies, midges, black flies, chigger mites, deer flies, fleas, gnats, horse flies, mosquitoes, sand flies, small flies, stable flies and ticks. Deet was developed and patented by the United States Department of Agriculture during World War II and was designated as a mosquito repellent for use by the United States Military in 1946. In the epa in 1957 as an insect ward off agent registration, began a civil, initially as a pesticide use on the farm, then the United States government to apply for the use in time of war, especially in Vietnam and southeast Asia, the United States environmental protection bureau statistics, every year, nearly 40% of americans use insect ward off agent containing deet, the world has a population of about 200 million, more than 40 years, more than 20000 research units of the research has proved that deet is currently on the market the most safe and effective broad spectrum displacement agent. The World Health Organization also recommends the use of deET-containing repellent products to prevent disease vector insects. It is often used in combination with other insecticides, but its toxicity is enhanced when used in combination with carbamate insecticides.
Details:
[Mechanism of action]
The mechanism of action of DEET is still unclear. It was originally believed that it relies on a deterrent smell to make bloodsucking insects resist after smelling and avoid getting close to the human body, so as to prevent bites.
However, studies have found that DEET can inhibit the electrophysiological response of mosquitoes to lactic acid, 1-octene-3-alcohol compounds and other major components of human sweat, conceal or block the smell system of mosquitoes, and prevent the identification of suitable prey.
Later, it was found that DEET directly acted on special olfactory neurons on mosquito antennae, producing repellent effect, and did not inhibit mosquitoes' perception of lactic acid, CO2, 1-octene-3-alcohol and other chemicals.
Recent studies have also found that the binding of DEET to some molecular targets is the first biochemical reaction to identify external substances, but these findings need to be verified later.