Tofacitinib Citrate...

Tofacitinib Citrate High quality 540737-29-9 High purity trader

Tofacitinib Citrate High quality 540737-29-9 High purity trader

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0 Metric Ton

Negotiable

  • Min.Order :0 Metric Ton
  • Purity: ≥99%

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Tofacitinib Citrate High quality 540737-29-9 High purity trader 540737-29-9

Quick Details

  • Appearance:White crystal
  • Application:Pharmaceutical excipient
  • PackAge:1kg/bag, 5kg/drum, 25kg/drum
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
  • Transportation:By air/by sea/by courier

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Tofacitinib Citrate High quality 540737-29-9 High purity trader 

Tofatinib targets the jaK-STAT signal transduction pathway in cells by inhibiting JAK phosphorylation, thereby preventing STAT phosphorylation, reducing the synthesis of downstream inflammatory cytokines, thus inhibiting CD-4T cell proliferation, blocking the synthesis and secretion of a variety of inflammatory cytokines to be anti-inflammatory and regulate the role of immunity. The study found that tofatinib blocked common cytokines in the c-chain (IL-2, IL-7, IL-9, IL-15 and IL-21, etc.) that bind to JAK3, as well as the gp130 families (IL-6 and IL-11) and the type II cytokine receptor families (IFN-α/β, IFN-γ, etc.). Since the drug also has a relatively weak inhibitory effect on JAK2, it can also block the beta-C family (IL-3, IL-5, GM-CSF, EPO and IFN gamma). Therefore, tofatinib can affect the differentiation of Th1 cells and the production of pathogenic Th17 cells by blocking JAK1 and JAK2. Since tofatinib has a blocking effect on IL-21, it is also hypothesized that it could impair the function of B cells and follicle-assisted T cells (Tfh cells).

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1) High quality, reasonable price and excellent service.
2) We have our own chemical sub-package warehouse, can do ciq and supply hazardous cargo packing license.
3) Company located in shandong province, which is famous for its chemical industry in china. and for most chemical products we can found producers here.
4) Nearby the world-famous seaport-qingdao. thereby we have smooth transportation ways for our worldwide clients.

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