Tofacitinib Citrate...

Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale

Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale

Min.Order / FOB Price:Get Latest Price

0 Metric Ton

Negotiable

  • Min.Order :0 Metric Ton
  • Purity: ≥99%

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Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale 540737-29-9

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  • Appearance:White crystal
  • Application:Pharmaceutical excipient
  • PackAge:1kg/bag, 5kg/drum, 25kg/drum
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
  • Transportation:By air/by sea/by courier

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Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale 

Tofatinib is an oral JAKs inhibitor with half the effective concentrations (IC50) of in vitro inhibition kinase JAK1, JAK2 and JAK3, and the ability to selectively inhibit JAK3 in cell experiments is more than 10 times higher than that of JAK2. Tofatinib can be combined with the co-chain of recep γ tors such as cytokines IL-2, 4, 7, 9 necessary to activate T cells. The drug has shown effective in mouse animal models of heart transplants, demonstrating the vital role of T-cells in transplant rejection.

Based on 4-chlorine-7H-gazprop and the starting material of 2,3-d , the amino protection reaction with toluene sulfonyl chloride (2) was obtained with 4-chlor-7-toluene sulfonylazepine and 2,3-d , compound 3 and (3R, 3R, 4R)-1-Pyri-4-Methyl-3-Methamine-Pyridine (4) has a substitution reaction, resulting in an N-(3R, 4R)-1-Pyri-4-Methyl-3-base-N-methyl-7-toluene sulfonylchidine 2,3-d) saccharine-4-amine (5), compound 5 by alkali hydrolysis to obtain N-(3R, 4R)-1-pyri-4-methyl-methyl-base-N-methyl-7H-gynaeco Nico-4-amine (6), compound 6 is protected by catalytic hydrogenation reaction deactivity to obtain N-(3R, 4R)-4-methyl-methyl-base-N-methyl-7H-gynaecogen and 2,3-d- saccharine-4-amine (7), Compound 7 reacts with ethyl cyanate to produce tofatinib,

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Hunan Warner Pharmaceutical Co., Ltd. is an innovation-leading pharmaceutical manufacturer. Since the company was founded in 2001, adhering to the "science and technology service health" of the enterprise purpose, adhere to the "great concentration pharmaceutical, treat people good faith" the management idea, taking the path of specialization, preliminary finished from chemical API to chemical medicine preparations, from medicinal plant, plant extraction and separation to traditional Chinese medicine preparations such as medicine, Chinese medicine two industrial chain system planning and construction of form a complete set, Research and development, production and sales in chemical medicine, traditional Chinese medicine and other fields coordinated and orderly development.

 

 

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