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MM-401(MM 401;MM401) 1442106-10-6 1442106-10-6
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MM-401 (MM 401;MM401) is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.
Details:
MM-401 (MM 401;MM401) is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.
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