Heparin Sodium

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Heparin Sodium

Product name:Heparin Sodium
Synonym: SODIUM HEPARIN;SODIUM HEPARINATE;REVIPARIN SODIUM;PORCINE HEPARIN SODIUM;BOVINE HEPARIN SODIUM;HEP, NA, BOVINE;HEP, NA, PORCINE;HEPARIN PORCINE SODIUM SALT
Chemical name: Heparin Sodium
Molecular Formula: (C12H16NS2Na3)20
Molecular Weight: 0
CAS NO: 9041-08-1
EC NO: 232-681-7
Purity: 99% 

Heparin sodium is an anticoagulant, is a kind of mucosaccharide, is extracted from the intestinal mucosa of pigs, cattle, sheep sodium salt glucosamine sulfate, in the human body is secreted by mast cells and naturally exists in the blood. Heparin sodium can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and resist the already formed thrombin, prevent the transformation of prothrombin into thrombin and anti-thrombin.

Heparin sodium can delay or prevent blood clotting in and out of the body. Its mechanism of action is very complex, and it has influence on many links in the process of coagulation. Its effects are as follows:

① inhibit the formation and action of thromboplastin, thereby preventing prothrombin from becoming thrombin;

②In higher concentrations, it can inhibit thrombin and other coagulation factors and prevent fibrinogen from becoming fibrin;

③ Can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate in its molecule, and the positively charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect. Because heparin can activate and release lipoprotein esterase in the body, so that chylomicron triglyceride and low-density lipoprotein hydrolysis, so it also has the effect of lowering blood lipid.

Heparin sodium can be used to treat acute thromboembolic disease, disseminated intravascular coagulation (DIC). In recent years, it has been found that heparin has the effect of clearing blood lipid. Intravenous injection or deep intramuscular injection (or subcutaneous injection), 5000 ~ 10000 units each time. The toxicity of heparin sodium is low, and spontaneous bleeding tendency is the main risk of heparin overdose. It is not effective orally and must be administered by injection. Intramuscular injection or subcutaneous injection is more irritating, occasionally allergic reactions can occur, and excessive amounts can even cause cardiac arrest; Occasional transient alopecia and diarrhea were seen. In addition, it can also cause spontaneous fracture. Long-term use can sometimes reverse the formation of blood clots.

 

product name	Heparin Sodium
appearance	White powder
assay	99.0% to 101.0%	99.9%
melting point	----	----
loss on drying	0.5%max.	0.22%
sulphated ash	0.1%max.	0.05%
acidity	0.01m naoh<0.50ml	0.39

 

 

Biochemical research, used to prevent the conversion of prothrombin into thrombin, has an antithrombotic effect.

 

 

 

 

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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

 

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