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Melanotan-II Melanotan 121062-08-6
Melanotropin; 4-Nle-7-phe-alpha-msh; 4-Norleucyl-7-phenylalanine-alpha-msh
Melanotan 2- Properties
Melanotan II is a synthetic peptide drug that is α- Derivatives of ketoglutathione. Melanotan II mainly acts on the skin and reproductive system, and its properties mainly include the following aspects.
1. Skin pigmentation regulation: Melanotan II can stimulate the production of melanin in the skin, making it appear dark brown. This melanin deposition gives the skin a tanned bronze color and increases its ability to resist UV damage.
2. Promoting libido: Melanotan II has the effect of promoting libido by stimulating the central nervous system α- Ergotamine receptors are used to increase sexual desire.
3. Appetite reduction: Melanotan II has a certain effect of reducing appetite by stimulating the central nervous system to change the activity of the satiety center, thereby reducing food intake.
4. Pharmacological effects: Melanotan II, as a short peptide, can be injected into the body via intravenous or subcutaneous injection. It will bind to hormone receptors in melanocytes or gonads of the skin and trigger a series of physiological reactions.
It should be noted that Melanotan II is an illegal drug and is listed as a banned drug in some countries. Before use, you should consult a doctor and follow their guidance for use. During use, there may be some side effects such as skin allergies, nausea, vomiting, etc., so caution should be exercised when using.
Last update: 2024-01-02 23:10:35
Melanotan 2- Application and synthesis methods
Methadone II is a synthetic analgesic drug and is also used as an alternative therapeutic drug. It is mainly used to alleviate moderate to severe chronic pain and to treat opioid dependence and withdrawal symptoms.
The synthesis method of Milanotan II is relatively complex, generally including the following steps:
1. Ethyl benzyl magnesium bromide reacts with N-acetyl morphine to generate alkyl magnesium halides with benzyl groups.
2. React the alkyl magnesium halide obtained in step 1 with benzoyl chloride to obtain the precursor of melatonin.
3. In the presence of iodine, ammonia gas or ammonia solution is used to ammonify the precursor of melatonin, producing melatonin II.
It should be noted that Milanotan II is a prescription drug and can only be used under the guidance of a doctor. During use, medication should be strictly followed according to the doctor's advice and dosage, and relevant safety guidelines should be followed.
Last update: 2024-01-02 23:10:35
Melanotan 2- Safety Information
Melanotan II is a commonly used anti-cancer drug, also known as Carboplatin. The following is the safety information for Melanotan II:
1. Before use, consult a doctor in detail and follow their instructions.
2. This medication is usually administered intravenously
in vitro study
Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system.
in vivo studies
Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after I .v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model.
CAS:
121062-08-6
MF:
C50H69N15O9
MW:
1024.18
EINECS:
1308068-626-2
MDL No.:
MFCD01318793
Density
1.43
RTECS
OL4225000
storage temp.
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility
H2O: 5 mg/mL, soluble
form
solid
pka
13.00±0.70(Predicted)
color
white
Water Solubility
Soluble to 0.70 mg/ml in water
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
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