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Eastling Sell Top quality Noopept
Eastling Sell Top quality Noopept
Eastling Sell Top quality Noopept
Eastling Sell Top quality Noopept
Eastling Sell Top quality Noopept

Eastling Sell Top quality Noopept

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1 Kilogram

FOB Price:USD 5.0000 -7.0000

  • Min.Order :1 Kilogram
  • Purity: 99%
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Keywords

Noopept 157115-85-0 GVS-111

Quick Details

  • Appearance:White crystalline powder
  • Application:Food,Cosmetics,Pharmaceutical,health products,food supplements,dietary supplements
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:2000|Kilogram|Month
  • Storage:in a cool&dry place
  • Transportation:FEDEX,DHL,UPS,AIR,SEA

Superiority:

CAS: 157115-85-0

Molecular Formula: C17H22N2O4

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  5. 157115-85-0

157115-85-0 - Names and Identifiers

Name ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Synonyms Noopept
GVS 111
SGS 111
GVS-111
noopept powder
Nootropic GVS-111
ethyl phenylacetyl-Pro-Gly
Ethyl 1-(phenylacetyl)-L-prolylglycinate
ethyl 1-(phenylacetyl)-L-prolylglycinate
N-(1-(Phenylacetyl)-L-prolyl)glycineethylester
N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester
Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester
Glycine, N-(1-(phenylacetyl)-L-prolyl)-, ethyl ester
(S)-ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxaMido)acetate
ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
CAS 157115-85-0
EINECS 1592732-453-0
InChI InChI=1/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1

157115-85-0 - Physico-chemical Properties

Molecular Formula C17H22N2O4
Molar Mass 318.37
Density 1.202±0.06 g/cm3(Predicted)
Melting Point 94.0 to 98.0 °C
Boling Point 547.3±50.0 °C(Predicted)
Flash Point 284.8°C
Solubility Soluble in DMSO (up to 25 mg/ml)
Vapor Presure 4.93E-12mmHg at 25°C
Appearance powder
Color white to beige
pKa 13.41±0.20(Predicted)
Storage Condition -20°C
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Refractive Index 1.548
In vitro study Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2].
In vivo study N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5].

Details:

Noopept

Mol Download Chemical properties

CAS:

157115-85-0

MF:

C17H22N2O4

MW:

318.37

EINECS:

1592732-453-0

MDL No.:

MFCD00941121

Properties

Melting point:

94.0 to 98.0 °C

Boiling point:

547.3±50.0 °C(Predicted)

Density 

1.202±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 25 mg/ml)

pka

13.41±0.20(Predicted)

form 

powder

color 

white to beige

optical activity

[α]/D -115 to -125°, c = 0.5 in chloroform-d

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

InChI

InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1

InChIKey

PJNSMUBMSNAEEN-AWEZNQCLSA-N

SMILES

C(OCC)(=O)CNC(=O)[C@@H]1CCCN1C(CC1=CC=CC=C1)=O

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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