Factory high qualit...

Factory high quality Argireline Acetate / Acetyl Hexapeptide-3/8
Factory high quality Argireline Acetate / Acetyl Hexapeptide-3/8

Factory high quality Argireline Acetate / Acetyl Hexapeptide-3/8

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1 Gram

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  • Min.Order :1 Gram
  • Purity: purity 98%-101%
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Keywords

Argireline Acetate 616204-22-9 Acetyl Hexapeptide-3

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

Argireline

CAS: 616204-22-9

Molecular Formula: C34H60N14O12S

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616204-22-9 - Names and Identifiers

Name Argireline
Synonyms Reproage
Argireline
Anti-Wrinkle Multi-Peptides
Ac-Glu-Glu-Met-Glu-Arg-Arg-NH2
Argireline,Acetyl hexapeptide-3, BR
N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
Argireline acetate Ac-Glu-Glu-Met-Arg-Arg-NH2
CAS 616204-22-9
EINECS 1592732-453-0
InChI InChI=1/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
InChIKey RJZNPROJTJSYLC-LLINQDLYSA-N

616204-22-9 - Physico-chemical Properties

Molecular Formula C34H60N14O12S
Molar Mass 889
Density 1.54
Solubility water soluble
Appearance lyophilized solid
Color white
pKa 4.43±0.10(Predicted)
Storage Condition -20°C
Refractive Index 1.66
In vitro study The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC 50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC 50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration.
In vivo study Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.

 

Introduction Argireline, also known as Botox, it is an oligopeptide that mimics the N-terminal 6 amino acids of SNAP-25 protein. Akirelin is one of the commonly used raw materials for high-end cosmetics. The main effect is to reduce wrinkles caused by facial expression muscle contraction, and to have an ideal effect on removing wrinkles around the forehead or eyes.
akirelin is a safer, cheaper and milder alternative to botulinum toxin. Akirelin participates in the competition of SNAP-25 in the site of the fusion vesicle complex, thus affecting the formation of the fusion vesicle complex, resulting in the vesicles can not effectively release neurotransmitters, so that muscle contraction is weakened, which can relax the muscles, soothing fine lines make the skin clear, can also promote cell regeneration to restore skin soft and elastic, so it is widely used in the preparation of cosmetics and health products.
Use Argireline, also known as botulinum-like, it is an oligopeptide that mimics the N-terminal 6 amino acids of SNAP-25 protein. Akirelin is one of the commonly used raw materials for high-end cosmetics. The main effect is to reduce wrinkles caused by facial expression muscle contraction, and to have an ideal effect on removing wrinkles around the forehead or eyes. In addition, it can also promote the production of collagen, help skin tissue reconstruction.
effect The sixth peptide, an oligopeptide mimicking the N-terminus of the SNAP-25 protein and consisting of six amino acids. By inhibiting the synthesis of SNARE acceptors, the six peptides inhibit the excessive release of catecholamines and acetylcholines in the skin, locally block the nerve to transmit muscle contraction signals, and relax the facial muscles, to achieve the purpose of smoothing fine lines.
preparation A preparation method of akerelin, comprising the following steps: Step 1: taking resin, activating, amino Resin; Step 2: Take the amino resin obtained in step 1, the first step coupling guanidine protected L-arginine, guanidine protected L-arginine, side Chain Amino-protected L-glutamine to obtain tripeptide resin; Step 3: Take the tripeptide resin obtained in step 2, and gradually couple L-methionine, side chain carboxyl-protected L-glutamic acid, N-acetyl-L-glutamic acid protected by side chain carboxyl group to obtain hexapeptide resin; Step 4: cleave the hexapeptide resin obtained in step 3 to obtain the first product; Step 5: the first product obtained in step 4 is purified and obtained.
biological activity Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable anti-wrinkle peptide. Argireline significantly inhibits Ca2 dependent neurotransmitter release at the neuromuscular junction. Argireline has anti-wrinkle and anti-aging effects.

Details:

Argireline

Mol Download Chemical properties

CAS:

616204-22-9

MF:

C34H60N14O12S

MW:

889

EINECS:

1592732-453-0

MDL No.:

MFCD09842097

Properties

Density 

1.54

storage temp. 

-20°C

solubility 

water soluble

solubility 

water soluble

form 

lyophilized solid

pka

4.43±0.10(Predicted)

color 

white

InChIKey

RJZNPROJTJSYLC-LLINQDLYSA-N

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

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