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Coluracetam 135463-81-9 Coluracetam powder
Coluracetam
CAS: 135463-81-9
Molecular Formula: C19H23N3O3
Name | Coluracetam |
Synonyms | BCI-540 Coluracetam COLURACETAM Coluracetam, MKC-231 1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)- 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide 1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one |
CAS | 135463-81-9 |
EINECS | 1308068-626-2 |
InChI | InChI=1/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23) |
Molecular Formula | C19H23N3O3 |
Molar Mass | 341.404 |
Density | 1.291g/cm3 |
Boling Point | 634.1°C at 760 mmHg |
Flash Point | 337.3°C |
Vapor Presure | 5.54E-16mmHg at 25°C |
Storage Condition | Room Temprature |
Refractive Index | 1.64 |
Physical and Chemical Properties | Storage conditions Sealed in dry,Room Temperature acidity coefficient (pKa) 12.01±0.20(Predicted) |
The chemical name of koalacetam (Coluracetam) is N-(2, 3-dimethyl-5, 6,7, 8-tetrahydrofurano [2,3-b] quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl) acetamide, which is a type of cettam drug under development, belongs to the cetam derivative. Sytam drugs are widely used in the clinical treatment of cognitive dysfunction and epilepsy due to their unique mechanism of action, remarkable curative effect and extremely low toxicity. The variety is still in clinical trials.
density: 1.291g/cm3
Boiling point: 634.1°C at 760 mmHg
Flash point: 337.3°C
Refractive index: 1.64
Vapor pressure: 5.54 E-16mmHg at 25°C
By participating in the HACU process, koalacetam increases the activity of cholinergic neurons by increasing the rate-limiting step of synaptic intake of cholinergic neurotransmitter acetylcholine, and has the ability to improve cognition.
1. for nootropic drugs. It can be used to treat memory and intellectual disorders caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development.
2. Antidepressant effect. By promoting the transmission of nerve signals, it has a significant effect on depression
Coluracetam (BCI-540, MKC-231) is a puzzle drug with cognitive and neuroprotective effects.
Mol Download Chemical properties
CAS:
135463-81-9
MF:
C19H23N3O3
MW:
341.4
EINECS:
1308068-626-2
MDL No.:
MFCD00901416
Boiling point:
634.1±55.0 °C(Predicted)
Density
1.291±0.06 g/cm3(Predicted)
storage temp.
Sealed in dry,Room Temperature
solubility
DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
pka
12.01±0.20(Predicted)
form
A crystalline solid
InChI
InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
InChIKey
PSPGQHXMUKWNDI-UHFFFAOYSA-N
SMILES
N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O
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