Factory high qualit...

Factory high quality Coluracetam
Factory high quality Coluracetam

Factory high quality Coluracetam

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1 Kilogram

FOB Price:USD 159.0000 -170.0000

  • Min.Order :1 Kilogram
  • Purity: purity 98%-101%
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Keywords

Coluracetam 135463-81-9 Coluracetam powder

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

Coluracetam

CAS: 135463-81-9

Molecular Formula: C19H23N3O3

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135463-81-9 - Names and Identifiers

Name Coluracetam
Synonyms BCI-540
Coluracetam
COLURACETAM
Coluracetam, MKC-231
1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-
2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide
N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one
CAS 135463-81-9
EINECS 1308068-626-2
InChI InChI=1/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)

135463-81-9 - Physico-chemical Properties

Molecular Formula C19H23N3O3
Molar Mass 341.404
Density 1.291g/cm3
Boling Point 634.1°C at 760 mmHg
Flash Point 337.3°C
Vapor Presure 5.54E-16mmHg at 25°C
Storage Condition Room Temprature
Refractive Index 1.64
Physical and Chemical Properties Storage conditions Sealed in dry,Room Temperature
acidity coefficient (pKa) 12.01±0.20(Predicted)

135463-81-9 - Introduction

The chemical name of koalacetam (Coluracetam) is N-(2, 3-dimethyl-5, 6,7, 8-tetrahydrofurano [2,3-b] quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl) acetamide, which is a type of cettam drug under development, belongs to the cetam derivative. Sytam drugs are widely used in the clinical treatment of cognitive dysfunction and epilepsy due to their unique mechanism of action, remarkable curative effect and extremely low toxicity. The variety is still in clinical trials.

 

135463-81-9 - Nature

density: 1.291g/cm3
Boiling point: 634.1°C at 760 mmHg
Flash point: 337.3°C
Refractive index: 1.64
Vapor pressure: 5.54 E-16mmHg at 25°C

 

135463-81-9 - Pharmacological effects

By participating in the HACU process, koalacetam increases the activity of cholinergic neurons by increasing the rate-limiting step of synaptic intake of cholinergic neurotransmitter acetylcholine, and has the ability to improve cognition.

 

135463-81-9 - Clinical trials adapt to symptoms

1. for nootropic drugs. It can be used to treat memory and intellectual disorders caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development.
2. Antidepressant effect. By promoting the transmission of nerve signals, it has a significant effect on depression

 

135463-81-9 - Biological activity

Coluracetam (BCI-540, MKC-231) is a puzzle drug with cognitive and neuroprotective effects.

Details:

Coluracetam

Mol Download Chemical properties

CAS:

135463-81-9

MF:

C19H23N3O3

MW:

341.4

EINECS:

1308068-626-2

MDL No.:

MFCD00901416

Properties

Boiling point:

634.1±55.0 °C(Predicted)

Density 

1.291±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol

pka

12.01±0.20(Predicted)

form 

A crystalline solid

InChI

InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)

InChIKey

PSPGQHXMUKWNDI-UHFFFAOYSA-N

SMILES

N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O

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