Factory high quality Prazosin hydrochloride

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1 Gram	FOB Price:USD 159.0000 -170.0000

1 Gram

FOB Price:USD 159.0000 -170.0000

Min.Order :1 Gram
Purity: purity 98%-101%
Payment Terms : L/C,T/T,Other

Keywords

Prazosin hydrochloride 19237-84-4 high quality Bpc157

Quick Details

Appearance:white powder
Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:20°
Transportation:20

Superiority:

prazosin hydrochloride

CAS: 19237-84-4

Molecular Formula: C19H22ClN5O4

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19237-84-4

19237-84-4 - Names and Identifiers

Name	prazosin hydrochloride
Synonyms	Prazosin HCl Prazosin hydrochlori prazosin hydrochloride Prazosin Hydrochloride (500 mg) 4-Amino-2-pyroyl-6,7-dimetoxypiperazin-1-yl-chynazolina hydrochloride 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazinehydr [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylMethanone Hydrochloride [4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone hydrochloride Furazosin hydrochloride, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride Prazosin hydrochloride,1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
CAS	19237-84-4
EINECS	242-903-4
InChI	InChI=1/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChIKey	WFXFYZULCQKPIP-UHFFFAOYSA-N

19237-84-4 - Physico-chemical Properties

Molecular Formula	C19H22ClN5O4
Molar Mass	419.86
Melting Point	277 - 280°C
Boling Point	638.4°C at 760 mmHg
Flash Point	339.9°C
Water Solubility	Soluble in dimethyl sulfoxide, ethanol, water, methanol.
Solubility	Soluble in dimethyl sulfoxide, ethanol, water, methanol.
Vapor Presure	3.4E-16mmHg at 25°C
Appearance	off-white to yellow powder
Color	white
Merck	14,7717
BRN	4303561
Storage Condition	2-8°C
MDL	MFCD00058177
Physical and Chemical Properties	Appearance: white or white crystalline powder moisture: less than or equal to 2.0% (anhydrous prazosin),<8-15% (hydrous prazosin) ignition residue: less than or equal to 0.4% heavy metals: ≤ 50ppm related substances: in accordance with the provisions of the content: according to the anhydrous C19H21N5O4HCL, not less than 99.0%, not more than 102.0
Use	Used as an antihypertensive agent

19237-84-4 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R62 - Possible risk of impaired fertility
Safety Description	S28 - After contact with skin, wash immediately with plenty of soap-suds. S36 - Wear suitable protective clothing.
UN IDs	3249
WGK Germany	3
RTECS	VA1350000
FLUKA BRAND F CODES	10
HS Code	2934990002
Hazard Class	6.1(b)
Packing Group	III

19237-84-4 - Reference Information

Overview	Prazosin hydrochloride (P razosin Hydrochloride) is a blocker that selectively acts on postsynaptic αl adrenergic receptors in blood vessels and nerves. It is a quinazoline derivative that can relax vascular smooth muscle, expand peripheral blood vessels, reduce peripheral blood vessel resistance, lower blood pressure, has no effect on presynaptic membrane α2 receptors, but can block postsynaptic membrane α1, anti-norepinephrine, new forlin and epinephrine boost response. Clinically, it is mainly used to treat various degrees of hypertension, chronic congestive heart failure and prostatic hyperplasia. The biggest advantage of prazosin hydrochloride is that it has no obvious adverse effect on metabolism, and has a good effect on blood lipid metabolism. It is especially effective for hypertensive patients with diabetes or renal insufficiency. Compared with other antihypertensive drugs, it has the following advantages: 1. Compared with other vasodilators, such as hydralazine, it rarely causes tachycardia and does not increase renin secretion; 2. It is different from clonidine, methyldopa and other antihypertensive drugs. It has no central nervous system effect and will not cause side effects such as depression, impotence, and loss of libido; 3. Prazosin does not affect renal function, no effect on renal blood flow and glomerular filtration rate. Studies have shown that a single dose of prazosin can effectively treat hypertension. When other antihypertensive drugs are used and the effect is not good or the dose cannot be increased due to side effects, the addition of prazosin can improve blood pressure. effect. There are no significant changes in renal function in hypertensive patients with long-term prazosin. In hypertension with renal insufficiency, many antihypertensive drugs can reduce renal blood flow and increase nitrogen retention. However, prazosin will not affect renal blood flow and can reduce nitrogen retention in the process of lowering blood pressure. This is an ideal antihypertensive drug for hypertension with renal insufficiency. In addition, prazosin also has certain application and effect in the treatment of refractory heart failure. Prazosin can selectively expand resistance blood vessels and volume blood vessels. It can expand both arterial blood vessels and venous blood vessels. It can reduce the front and back load of the heart of patients with severe heart failure in a balanced manner and improve the heart pumping function. It is worthy of clinical promotion. Fig. 1 is the structural formula of prazosin hydrochloride
pharmacological effects	this product is a selective postsynaptic α1 adrenergic receptor blocker. It can dilate the surrounding blood vessels and reduce the vascular resistance and cause the blood pressure to drop. It does not block presynaptic membrane α2 receptors, has no obvious effect on heart rate and cardiac output, and does not increase renin secretion. This medicine can dilate arteries and veins, reduce the load before and after the heart, reduce the end diastolic pressure of the left ventricle, and improve the heart function, so it can be used for heart failure.
terazosin hydrochloride	terazosin hydrochloride is mainly used to treat mild or moderate hypertension, reducing blood pressure by reducing total peripheral vascular resistance. The vasodilation and blood pressure lowering effects of terazosin seem to be mainly caused by a1-adrenergic receptor blockade. It can be administered alone or in combination with other antihypertensive drugs such as thiazide diuretics or β-blockers. It can also be used for the treatment of symptoms of urinary retention caused by benign prostatic hyperplasia (BPH). Male patients are basically completely absorbed after taking medicine. The effect of taking medicine immediately after a meal on the degree of absorption is minimal, but the time to peak plasma concentration is delayed by about 40 minutes. The hepatic first pass metabolism of terazosin is very small. The peak is reached about 1 hour after taking the drug, and the half-life is about 12 hours. In the study of the effect of age on the pharmacokinetics of terazosin, it was found that the plasma half-lives of patients aged 70 and 20 to 39 years old were 14.0 and 11.4 hours respectively. The plasma protein binding rate was 90% ~ 94%. About 40% is excreted in urine and about 60% is excreted in feces. In clinical trials, the proportion of patients treated with this product and angiotensin (ACE) inhibitors and diuretics reported vertigo or other related adverse reactions was higher than that of all patients treated with this product. When this product is combined with other antihypertensive drugs, attention should be paid to observe to avoid significant hypotension. When this product is added to diuretics or other antihypertensive drugs, the dose should be reduced and reformulated if necessary. It is known that this product will not interact with analgesics/anti-inflammatory drugs, cardiac glycosides, hypoglycemic drugs, antiarrhythmic drugs, antianxiety drugs/sedatives, antibacterial drugs, hormones/steroids and gout drugs. Overdose of this product may cause acute hypotension. Cardiovascular support therapy should be used in this method. Patients should lie on their backs to restore blood pressure and normalize heart rate. If this method cannot be solved, the volume should be expanded first to treat shock, and vasopressors should be used if necessary. Renal function should be monitored and routine supportive therapy should be applied. Because this product has a high plasma protein binding rate, dialysis is ineffective.
pharmacokinetics	oral absorption is complete, bioavailability is 50% ~ 85%. The plasma protein binding rate was 97%. It took effect 30 min after oral administration, reached a peak of 1~2h, and lasted for 10h. The best time for the combination is after 3 to 4 weeks. The drug is metabolized in the liver, and the main metabolites are excreted through bile and feces. A small amount (6% ~ 10%) is excreted from the kidney. The drug cannot be removed by dialysis.
use	suitable for mild to moderate hypertension, combined with beta blockers or diuretics, the antihypertensive effect is better. As a second-line drug, it is often used or combined when the first-line drug treatment is not satisfactory; it is used to treat moderate and severe chronic congestive heart failure and heart failure after myocardial infarction, and it is also effective for refractory heart failure. Can be used to treat ergotamine overdose. (2016-6-16) Used as an antihypertensive drug

Details:

Prazosin hydrochloride

Mol Download Chemical properties

CAS:

19237-84-4

MF:

C19H22ClN5O4

MW:

419.86

EINECS:

242-903-4

MDL No.:

MFCD00058177

Properties

Melting point:

277 - 280 °C

storage temp.

2-8°C

solubility

H₂O: 1 mg/mL, clear, colorless

form

solid

color

white

Water Solubility

Soluble in dimethyl sulfoxide, ethanol, water, methanol.

Merck

14,7717

BRN

4303561

InChIKey

WFXFYZULCQKPIP-UHFFFAOYSA-N

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