Eastling Sell Top quality Kanamycin Sulphate

Superiority:

kanamycin sulfate mixture of components A

CAS: 70560-51-9;25389-94-0;133-92-6

Molecular Formula: C18H38N4O15S

1. Home
2. Product Category
3. Biomedicine
4. Veterinary medicine
5. 25389-94-0

25389-94-0 - Names and Identifiers

25389-94-0 - Physico-chemical Properties

25389-94-0 - Risk and Safety

25389-94-0 - Upstream Downstream Industry

25389-94-0 - Reference

25389-94-0 - Reference Information

Last Update：2023-12-21 00:21:33

25389-94-0 - Nature

Storage Conditions 2-8°C
Solubility H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
form powder

Last Update：2024-01-02 23:10:35

25389-94-0 - Safety Information

Mark Xi,T
Hazard code 61
WGK Germany 3
Rpecs# NZ3225030

Last Update：2024-01-02 23:10:35

25389-94-0 - Role and use

This product is aminoglycoside broad-spectrum antibiotics, antibacterial spectrum and neomycin similar. The main Gram-negative bacteria such as Escherichia coli, Klebsiella, Proteus, Pneumonia Bacillus, Enterobacter aerogenes and Shigella caused by serious infection, the drug resistance of Staphylococcus aureus also has a good antibacterial effect. Clinically, it is mainly used for pulmonary infection, urinary tract infection, biliary tract infection, sepsis and abdominal infection caused by sensitive bacteria, and the latter two are often used in combination with other antibacterial drugs. Can also be used for other antibiotic resistance and sensitive to this product of Staphylococcus aureus infection. For the treatment of tuberculosis, this product can be used as a second-line drug.

principle

1. This product mainly binds to the 30S subunit of bacterial ribosomes and inhibits bacterial protein synthesis. In recent years, the number of resistant strains has increased significantly, because some bacteria produce aminoglycoside inactivation enzymes, so that the loss of antibacterial activity. Kanamycin and streptomycin, neomycin have complete cross-resistance, and other aminoglycosides may have some cross-resistance.
2. This product mainly binds to the 30S subunit of bacterial ribosomes and inhibits bacterial protein synthesis.

Last Update：2024-01-02 23:10:35

25389-94-0 - Dosage and usage

1. adult dosage: intramuscular injection or intravenous infusion, once 0.5g, once every 12 hours; Or according to body weight once 7.5mg/kg, once every 12 hours, adult daily dosage should not exceed 1.5g, treatment is not easy to exceed 14 days. Patients over 50 years of age should be appropriately reduced.
2. Children's usual dosage: intramuscular injection or intravenous drip, according to the weight of 15-25mg/kg a day, divided into two doses.
3. dosage when renal function decreases: creatinine clearance 50-90mg/min with 60-90% of the normal dose, once every 12 hours (normal dose is 7.5mg/kg each time, once every 12 hours); Creatinine clearance 10-50mg/min with 30-70% of the normal dose, once every 12-18 hours; Creatinine clearance <10mg/min with 20-30% of the normal dose, every 24-48 hours.

Last Update：2024-01-02 23:10:35

25389-94-0 - Adverse reactions

1. This product is toxic, and the main toxicity is the toxicity of the eighth pair of cranial nerves.
2. Renal toxicity, often can cause mild proteinuria, tubular urine and urine in a small number of red blood cells, white blood cells, occasionally can cause blood urea nitrogen increased.
3. neurotoxic manifestations are muscular nerve block, which can cause respiratory paralysis, sensory numbness, visual abnormalities, etc.
4. allergic reactions, there may be maculopapular rash, drug fever, skin itching, eosinophilia and so on.
5. Compatibility with alkaline drugs may increase toxicity. The antibacterial activity of this product in the urinary system can be enhanced with the same use of alkalinizing urine drugs, but the toxicity is also increased, so the dose must be reduced accordingly.
6. the general course of treatment should not exceed 2 weeks, and should be used with caution in patients with renal dysfunction. The dose should be reduced in elderly patients.